Results 11 to 20 of about 340,047 (304)
On phagocytes and macular degeneration [PDF]
Progress in Retinal and Eye Research, 2017 Age related macular degeneration (AMD) is a complex multifactorial disease caused by the interplay of age and genetic and environmental risk factors. A common feature observed in early and both forms of late AMD is the breakdown of the physiologically immunosuppressive subretinal environment and the protracted accumulation of mononuclear phagocytes (MP)
Xavier Guillonneau +5 more
openaire +4 more sources
Medicinal plants and natural products as neuroprotective agents in age-related macular degeneration
Neural Regeneration Research, 2020 The retina may suffer neurodegenerative damages, as other tissues of the central nervous system do, and serious eye diseases may develop. One of them is age-related macular degeneration, which causes progressive loss of vision due to retina degeneration.
Francisco Bosch-Morell +9 more
doaj +2 more sources
Age-related macular degeneration
Community Eye Health Journal, 2014 Age-related macular degeneration (AMD) is a disease of the retina that usually develops in people aged 60 years and older. It affects about 8.7% of the world’s population and is the leading cause of blindness among people aged 50 and older in ...
Wanjiku Mathenge
doaj +1 more source
Age-related macular degeneration
Clinical Ophthalmology, 2011 Giuseppe Querques¹, Fernando Onofrio Avellis1,2, Lea Querques1,3, Francesco Bandello³, Eric H Souied¹ ¹Service d'Ophtalmologie, Centre Hospitalier Intercommunal Créteil, Université Paris ...
Querques G +4 more
doaj +1 more source
A Mechanistic Dissection of Multifaceted Complement Attack in Age-Related Macular Degeneration Reveals the Superiority of C3 Inhibition. [PDF]
Adv Sci (Weinh)Complement‐mediated RPE degeneration extends beyond terminal MAC injury. A four‐hit mechanism emerges in which C3a and C5a disrupt mitochondrial function, while C3b and MAC compromise the phagolysosomal system. Upstream C3 inhibition suppresses this full spectrum of pathogenic effectors, providing broader cellular protection than C5 blockade.
Chen Z, Wang M, Liu H, Qian F.
europepmc +2 more sources
Modelling the Genetic Risk in Age-Related Macular Degeneration [PDF]
, 2012 Late-stage age-related macular degeneration (AMD) is a common sight-threatening disease of the central retina affecting approximately 1 in 30 Caucasians.
Weber, Bernhard H. F. +29 more
core +1 more source
The estimated prevalence and incidence of late stage age related macular degeneration in the UK [PDF]
, 2012 BACKGROUND: UK estimates of age related macular degeneration (AMD) occurrence vary. AIMS: To estimate prevalence, number and incidence of AMD by type in the UK population aged ≥50 years.
Fletcher, AE +11 more
core +1 more source
mTORC1 and mTORC2 are differentially engaged in the development of laser-induced CNV
Cell Communication and Signaling, 2019 Background The mechanistic target of rapamycin (mTOR) pathway is a potential target to inhibit pathologic processes in choroidal neovascularization. However, the exact role of mTOR signaling in the development of CNV remains obscure.
Jin Young Yang +7 more
doaj +1 more source
Candidate gene study of macular response to supplemental lutein and zeaxanthin. [PDF]
, 2013 Supplementation with carotenoids is proposed to protect against age-related macular degeneration. There is, however, considerable variability in retinal macular pigment response, which may be due to underlying genetic variation. The purpose of this study
Liew, SH Melissa +10 more
core +1 more source