Complement C3 variant and the risk of age-related macular degeneration [PDF]
New England Journal of Medicine, 2007 Background: Age-related macular degeneration is the most common cause of blindness in Western populations. Susceptibility is influenced by age and by genetic and environmental factors.
Armbrecht, AM +16 more
core +3 more sources
Generative mathematical modelling to demonstrate virtual simulations of neovascular age related macular degeneration. [PDF]
PLoS ONE, 2017 To develop a generative mathematical model of wet age-related macular degeneration (AMD) and model the impact of injections of anti-vascular endothelial growth factor to virtual patients with the condition.We isolated key pathophysiological components of
David Hoyle, Tariq Mehmood Aslam
doaj +1 more source
Molecular Therapy: Methods & Clinical Development, 2019 Adeno-associated virus (AAV) vector-mediated gene delivery is a promising approach for therapy, but implementation in the eye currently is hampered by the need for delivering the vector underneath the retina, using surgical application into the ...
Hongman Song +5 more
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Prevalence of age-related macular degeneration in Nakuru, Kenya: a cross-sectional population-based study. [PDF]
, 2013 BACKGROUND: Diseases of the posterior segment of the eye, including age-related macular degeneration (AMD), have recently been recognised as the leading or second leading cause of blindness in several African countries.
Bastawrous, Andrew +5 more
core +6 more sources
Dietary fatty acids and lipoproteins on progression of age-related macular degeneration [PDF]
, 2017 Age-related macular degeneration (AMD) is a medical condition of central loss vision and blindness. Numerous studies have revealed that changes on certain dietary fatty acids (FAs) could have useful for AMD management.
Abia González, María del Rocío +5 more
core +3 more sources
Morphologic Criteria of Lesion Activity in Neovascular Age-Related Macular Degeneration: A Consensus Article [PDF]
, 2017 Intravitreal antivascular endothelial growth factor drugs represent the current standard of care for neovascular age-related macular degeneration (nAMD).
Elena Gusson +8 more
core +1 more source
mTORC1 and mTORC2 are differentially engaged in the development of laser-induced CNV
Cell Communication and Signaling, 2019 Background The mechanistic target of rapamycin (mTOR) pathway is a potential target to inhibit pathologic processes in choroidal neovascularization. However, the exact role of mTOR signaling in the development of CNV remains obscure.
Jin Young Yang +7 more
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Cost effectiveness of treatments for wet age-related macular degeneration [PDF]
, 2011 Age-related macular degeneration (AMD) is a leading cause of blindness in people aged >= 50 years. Wet AMD in particular has a major impact on patient quality of life and imposes substantial burdens on healthcare systems.
Annemans, Lieven +4 more
core +1 more source
Open innovation in neuroscience research and drug discovery
Brain and Neuroscience Advances, 2018 The pressures on the pharmaceutical industry have incentivised a number of new collaborative models of research and development which can be categorised as open innovation.
Ann J. Hunter, Wen H. Lee, Chas Bountra
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New Frontiers in Retina: highlights of the 2020 angiogenesis, exudation and degeneration symposium
International Journal of Retina and Vitreous, 2020 We summarize the most important findings presented at the 2020 angiogenesis, exudation and degeneration symposium in five topic areas: (1) epidemiology of retinal vascular disease and macular degeneration; (2) dry AMD and geographic atrophy; (3 ...
Carmen A. Puliafito, Charles C. Wykoff
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