Results 21 to 30 of about 340,047 (304)

Structural basis for complement factor H-linked age-related macular degeneration [PDF]

, 2007
Nearly 50 million people worldwide suffer from age-related macular degeneration (AMD), which causes severe loss of central vision. A single-nucleotide polymorphism in the gene for the complement regulator factor H (FH), which causes a Tyr-to-His ...
Pietro Roversi, Robert B. Sim, Susan M. Lea, Jowitt, Thomas A., Beverly E. Prosser, Prosser, Beverly E., Day, Anthony J., Herbert, AP, Dušan Uhrín, Sim, Robert B., Uhrin, Dusan, Johnson, S, Steven Johnson, Blaum, Barbel S., Barlow, Paul N., Barlow, PN, Sim, RB, Simon J. Clark, Johnson, Steven, Thomas A. Jowitt, Jowitt, Thomas A.; id_orcid, Edward Tarelli, Jess Tyrrell, Lea, Susan M., Tyrrell, J, Blaum, BS, Herbert, Andrew P., Clark, Simon J., Tyrrell, Jess, Day, Anthony J.; id_orcid, Lea, Susan, Tarelli, E, Clark, SJ, Paul N. Barlow, Bärbel S. Blaum, Clark, Simon; id_orcid, Tarelli, Edward, Prosser, BE, Jowitt, TA, Day, AJ, Andrew P. Herbert, Roversi, Pietro, Anthony J. Day, Barlow P. N., Jowitt T. A., Herbert A. P., Johnson S., Tarelli E., Sim R. B., Uhrin D., Prosser B. E., Roversi P., Tyrrell J., Day A. J., Lea S. M., Blaum B. S., Clark S. J., Uhrín, D   +57 more
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Open innovation in neuroscience research and drug discovery

Brain and Neuroscience Advances, 2018
The pressures on the pharmaceutical industry have incentivised a number of new collaborative models of research and development which can be categorised as open innovation.
Ann J. Hunter, Wen H. Lee, Chas Bountra
doaj   +1 more source

Long-term visual and microperimetry outcomes following autologous retinal pigment epithelium choroid graft for neovascular age-related macular degeneration [PDF]

, 2009
To describe the 2- to 4-year visual and microperimetry outcomes of autologous retinal pigment epithelium (RPE)-choroid graft in patients with neovascular age-related macular degeneration (AMD).In this retrospective cohort study, 12 patients with ...
Coffey, PJ, Uppal, GS, Rubin, GS, Tufail, A, Franzco, FKC, Aylward, GW, Da Cruz, L, MacLaren, RE, Fred K Chen, Gary S Rubin, Robert E MacLaren, G William Aylward, Maclaren, Robert, Adnan Tufail, Gurmit S Uppal, Peter J Coffey, Chen, FK, Lyndon Da Cruz   +17 more
core   +1 more source

The role of oxidative stress and antioxidants in the pathogenesis of age-related macular degeneration

Clinics, 2011
OBJECTIVE: To investigate the role of oxidant/antioxidant status and protein oxidation in the development of age-related macular degeneration. METHOD: The activities of serum superoxide dismutase and glutathione peroxidase and the levels of serum ...
Zuhal Yildirim, Nil Irem Ucgun, Filiz Yildirim   +2 more
doaj   +1 more source

Dual Sensory Impairment: The Correlation between Age Related Macular Degeneration and Sensorineural Hearing Loss

Medicina, 2022
The pathogeneses of age-related macular degeneration (AMD) and age-related hearing impairment are not yet fully understood. If AMD and age-related hearing impairment are correlated, the cause of both may be a result of a common vulnerability.
Marina Istrate, Mihai Hasbei-Popa, Daniela Adriana Iliescu, Ana Cristina Ghiță, Brigitha Vlaicu, Mihai Aurelian Ghiță   +5 more
doaj   +1 more source

Novel rodent models for macular research [PDF]

, 2010
BACKGROUND: Many disabling human retinal disorders involve the central retina, particularly the macula. However, the commonly used rodent models in research, mouse and rat, do not possess a macula.
Gesine Huber, Muehlfriedel, Regine, Huber, G., Feng, Yuxi, Seeliger, M., Tanimoto, Naoyuki, Tanimoto Naoyuki, Severin Heynen, Hans-Peter Hammes, Christian Grimm, Feng, Y., Imsand Coni, Imsand, Coni, Muehlfriedel Regine, Susanne C. Beck, Huber, Gesine, Heynen, S., Grimm Christian, Regine Muehlfriedel, Huber Gesine, vom Hagen Franziska, Coni Imsand, Imsand, C., Seeliger Mathias W., Mühlfriedel, R., Peichl, Leo, Mathias W Seeliger, vom Hagen, F., Mühlfriedel, Regine, Tanimoto, N., Heynen Severin, Hammes, Hans-Peter, Seeliger, Mathias W, Beck Susanne C., Seeliger, Mathias W., Peichl Leo, Yuxi Feng, Peichl, L., Beck, Susanne C; https://orcid.org/, Grimm, C., Feng Yuxi, Mathias W. Seeliger, Leo Peichl, Franziska vom Hagen, Grimm, Christian, Grimm, Christian; https://orcid.org/, vom Hagen, Franziska, Beck, S., Beck, Susanne Christiane, Hammes Hans-Peter, Susanne C Beck, Naoyuki Tanimoto, Hammes, H., Heynen, Severin, Beck, Susanne C.   +54 more
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New Frontiers in Retina: highlights of the 2020 angiogenesis, exudation and degeneration symposium

International Journal of Retina and Vitreous, 2020
We summarize the most important findings presented at the 2020 angiogenesis, exudation and degeneration symposium in five topic areas: (1) epidemiology of retinal vascular disease and macular degeneration; (2) dry AMD and geographic atrophy; (3 ...
Carmen A. Puliafito, Charles C. Wykoff
doaj   +1 more source

The Association Between Consumption of 100% Fruit Juice and Risk of Age-Related Macular Degeneration: Data From the National Health and Nutrition Examination Survey Database

Frontiers in Nutrition, 2022
Age-related macular degeneration (AMD) is the main irreversible blindness disease worldwide. The current study aimed to investigate whether the consumption of 100% fruit juice increases the risk of age-related macular degeneration and find approaches to ...
Mi Song, Mi Song, Baihua Chen, Baihua Chen   +3 more
doaj   +1 more source

Prevalence of age-related macular degeneration in Nakuru, Kenya: a cross-sectional population-based study. [PDF]

, 2013
BACKGROUND: Diseases of the posterior segment of the eye, including age-related macular degeneration (AMD), have recently been recognised as the leading or second leading cause of blindness in several African countries.
Peto, Tunde; id_orcid, Bastawrous, Andrew, Andrew Bastawrous, Foster, Allen, Kuper Hannah, Allen Foster, Tunde Peto, Hannah Kuper, Tunde Peto (295260), Leung Irene, Irene Leung (336330), Leung, Irene, Wanjiku Mathenge (336328), Bastawrous Andrew, Andrew Bastawrous (336329), Peto Tunde, Hannah Kuper (25751), Wanjiku Mathenge, Allen Foster (94749), Peto, Tunde, Kuper, Hannah, Mathenge Wanjiku, Irene Leung, Mathenge, Wanjiku, Foster Allen   +24 more
core   +1 more source

Extracellular vesicles as a potential therapeutic for age-related macular degeneration

Neural Regeneration Research, 2023
Age-related macular degeneration is a major global cause of central visual impairment and severe vision loss. With an aging population, the already immense economic burden of costly anti-vascular endothelial growth factor treatment is likely to increase.
Lorraine L. C. Chow, Ben Mead
doaj   +1 more source