Results 71 to 80 of about 160,800 (350)

Avaliação dos efeitos adversos desencadeados pelo uso de difosfato de cloroquina, com ênfase na retinotoxicidade, em 350 doentes com lúpus eritematoso Evaluation of adverse events triggered by the use of chloroquine diphosphate, emphasis on retina toxicity, in 350 patients with lupus erythematosus

open access: yesAnais Brasileiros de Dermatologia, 2005
FUNDAMENTOS: A ocorrência de retinopatia pela cloroquina vem diminuindo em todo o mundo, com poucos estudos brasileiros sobre o problema. OBJETIVOS: Compreender melhor a fisiopatologia das reações tipo 1.
Maria Raquel Nogueira C. Ponchet   +3 more
doaj   +1 more source

Genome‐Wide Aggregated Trans Effects Analysis Identifies Genes Encoding Immune Checkpoints as Core Genes for Rheumatoid Arthritis

open access: yesArthritis &Rheumatology, EarlyView.
Objective The sparse effector “omnigenic” hypothesis postulates that the polygenic effects of common single nucleotide polymorphisms (SNPs) on a typical complex trait are mediated by trans effects that coalesce on expression of a relatively sparse set of core genes.
Athina Spiliopoulou   +9 more
wiley   +1 more source

Therapeutic potential of co-enzyme Q10 in retinal diseases [PDF]

open access: yes, 2017
Coenzyme Q10 (CoQ10) plays a critical role in mitochondrial oxidative phosphorylation by serving as an electron carrier in the respiratory electron transport chain.
Marcheggiani, Fabio   +6 more
core   +1 more source

Mechanisms of Macular Degeneration

open access: yesVision Research, 2010
The 12th Annual Vision Research Conference, ‘‘Mechanisms of Macular Degeneration” was held at the Convention Center at Ft. Lauderdale, Florida, May 1–2, 2009. The meeting reviewed the latest developments in the genetics of AMD, and focused on animal models that closely mimic early or late onset human macular diseases.
Greg Hageman   +4 more
openaire   +2 more sources

Nanostructured drug delivery systems for posterior segment eye diseases: Strategies to defy ocular barriers

open access: yesBMEMat, EarlyView.
Efficient drug delivery to the posterior segment of the eye has long been a challenging issue due to the complex ocular barriers. The review focuses on the promise held by nanoplatforms for barrier penetration and the key mechanisms involved, also highlighting their advantages in achieving efficient drug delivery and superior treatment of PSEDs ...
Yifan Shen   +7 more
wiley   +1 more source

Macular pigment and age related macular degeneration [PDF]

open access: yesBritish Journal of Ophthalmology, 1999
The yellow coloration of the macula lutea is attributable to the presence of macular pigment in the axons of its photoreceptors.1 In the 1980s several investigators demonstrated that macular pigment consists of the xanthophyll isomers, lutein and zeaxanthin.2 3 Although the role of the macular pigment remains uncertain, several functions have been ...
Beatty, S.   +4 more
openaire   +4 more sources

The Postbiotic Potential of Microalgae

open access: yesFood Frontiers, EarlyView.
Description of “Microalgal Postbiotic” following ISAPP Consensus (Salminen et al. 2021b) (Icons produced with Biorender) ABSTRACT The International Scientific Association for Probiotics and Prebiotics (ISAPP) has defined postbiotics as “preparations of inanimate microorganisms and/or their components that confer a health benefit on the host ...
Francesco Martelli   +2 more
wiley   +1 more source

Blindness incidence in Germany - A population-based study from Württemberg-Hohenzollern [PDF]

open access: yes, 1999
Few data on the incidence of blindness in Germany are available. We analysed causes of legal blindness for the region Württemberg-Hohenzollern (population 5.5 million) in order to help fill in this gap.
Klauss, V.   +4 more
core   +1 more source

Phytochemical Contents and Bioactive Compounds in Widely Consumed Cereals, Legumes, and Vegetables in Abruzzo Region, Italy: A Critical Review

open access: yesFood Safety and Health, EarlyView.
This review aims to collect and identify cereals, legumes, and vegetables mostly consumed in the Abruzzo region from 2020 till now, pointing attention to their biological effects. ABSTRACT The Abruzzo region boasts a wide range of typical food products including cereals, legumes, and vegetables. In this context, they take part in the Mediterranean diet,
Giulia Gentile   +3 more
wiley   +1 more source

Nutrients for Prevention of Macular Degeneration and Eye-Related Diseases

open access: yesAntioxidants, 2019
The risk of macular degeneration can be reduced through the consumption of antioxidant-rich foods, supplements, and nutraceutical formulas. This review focuses on the antioxidants, vitamins, and minerals that have been reported for reducing the risk of ...
Hock Eng Khoo   +4 more
doaj   +1 more source

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