Results 71 to 80 of about 450,506 (276)

The Paradox of Chivalric Madness: Ariosto’s and Cervantes’s Madness Representations’ Impact on Disability Representation

Humanities
This study investigates the connection between madness and critiques of the chivalric romance genre in two late Renaissance works, Ludovico Ariosto’s Orlando Furioso and Miguel de Cervantes’s Don Quijote de la Mancha.
Nicholas L. Johnson
doaj   +1 more source

A Delphi survey to determine how educational interventions for evidence-based practice should be reported:Stage 2 of the development of a reporting guideline [PDF]

, 2014
BACKGROUND: Undertaking a Delphi exercise is recommended during the second stage in the development process for a reporting guideline. To continue the development for the Guideline for Reporting Evidence-based practice Educational interventions and ...
Galipeau, James, Glasziou, Paul, Hammick, Marilyn, Lewis, Lucy K., McEvoy, Maureen P., Moher, David, Phillips, Anna C., Tilson, Julie K., Williams, Marie T.   +8 more
core   +1 more source

Mammalian Proteome Profiling Reveals Readers and Antireaders of Strand‐Symmetric and ‐Asymmetric 5‐Hydroxymethylcytosine‐Modifications in DNA

Advanced Science, EarlyView.
We investigate by proteomics studies how strand‐symmetric and ‐asymmetric cytosine 5‐modifications in DNA are selectively recognized by the nuclear proteome. Using promoter probes with defined modification patterns, we identify tissue‐specific reader proteinsincluding MYC, MAX, and RFX5that discriminate 5‐hydroxymethylcytosine symmetry and sequence ...
Lena Engelhard, Zeyneb Vildan Cakil, Marlon S. Zambrano‐Mila, Simone Eppmann, Tye Gonzalez, Rasmus Linser, Petra Janning, Sidney Becker, Daniel Summerer   +8 more
wiley   +1 more source

Centromeric cohesion failure invokes a conserved choreography of chromosomal mis-segregations in pancreatic neuroendocrine tumor

Genome Medicine, 2020
Background Pancreatic neuroendocrine tumors (PANETs) are rare, slow growing cancers that often present with local and distant metastasis upon detection.
Rene Quevedo, Anna Spreafico, Jeff Bruce, Arnavaz Danesh, Samah El Ghamrasni, Amanda Giesler, Youstina Hanna, Cherry Have, Tiantian Li, S. Y. Cindy Yang, Tong Zhang, Sylvia L. Asa, Benjamin Haibe-Kains, Monika Krzyzanowska, Adam C. Smith, Simron Singh, Lillian L. Siu, Trevor J. Pugh   +17 more
doaj   +1 more source

Proteogenomic Characterization Reveals Subtype‐Specific Therapeutic Potential for HER2‐Low Breast Cancer

Advanced Science, EarlyView.
Multiomic profiling of HER2‐low breast cancer identifies three proteomic subtypes with distinct therapeutic strategies: endocrine, antiangiogenic, and anti‐HER2 therapies. Genomic and lactate modification landscapes are detailed, providing insights for precise management.
Shouping Xu, Keda Yu, Lei Liu, Qin Wang, Xiaohui Wu, Yihai Chen, Guozheng Li, Xin Zhang, Bo Wei, Zitong Fu, Abiyasi Nanding, Zuxianglan Zhao, Lingbing Yang, Xingda Zhang, Jianyu Wang, Wantong Sun, Yi Hao, Zhongyi Cheng, Xiaojiang Cui, Hao Wu, Da Pang   +20 more
wiley   +1 more source

Tom40 functions as a channel for protein retrotranslocation in the mitochondria-associated degradation (MAD) pathway

Communications Biology
The mitochondria-associated degradation pathway (MAD) mediates removal and elimination of damaged, unfolded mitochondrial proteins by the ubiquitin-proteasome system (UPS).
Pin-Chao Liao, Tzu-Ying Lin, Catherine A. Tsang, Chen-Jing Huang, Katherine Filpo, Istvan Boldogh, Liza A. Pon   +6 more
doaj   +1 more source

Scheduling for non regular performance measure under the due window approach [PDF]

, 1999
Cataloged from PDF version of article.In the last two decades, Just-In-Time (JIT) production has proved to be an essential requirement of world class manufacturing. This has made schedulers most concerned about the realization of a JIT environment.
Lejmi, T., Sabuncuoglu, I.
core   +1 more source

A Trypsin‐Like Serine Protease ZmNAL1a Fine‐Tunes Maize Floral Transition and Flowering Time

Advanced Science, EarlyView.
This study identifies a trypsin‐like serine protease, ZmNAL1a, that moves from leaves to the shoot apical meristem. ZmNAL1a promotes the floral transition by degrading TOPLESS‐like corepressor REL2, which thereby enhances the expression of key flowering genes through elevating histone acetylation and relieving REL2–ZmEREBP147‐mediated transcriptional ...
Nan Li, Qiang Ning, Zhen Li, Qian Zhang, Peilu Zhu, Jimin Zhan, Yunfu Li, Zhen Li, Liang Dong, Qing Xiong, Jiahao Liao, Jie Liu, David Jackson, Munenori Kitagawa, Zuxin Zhang, Lei Liu   +15 more
wiley   +1 more source

N-terminal pro-brain natriuretic peptide: a potential follow-up biomarker of mandibular advancement device efficacy on cardiac function in obstructive sleep apnea [version 2; referees: 2 approved]

F1000Research, 2019
Interrelationships between obstructive sleep apnea (OSA) and cardiovascular diseases are now recognized, but some underlying pathophysiological mechanisms remain controversial.
Denis Monneret
doaj   +1 more source

Why Mad Studies Needs Survivor Research and Survivor Research Needs Mad Studies [PDF]

, 2016
Mad Studies and survivor research are emerging fields of enquiry whose goals and boundaries are continually being shaped. This paper aims to explore intersections between the two fields and argues that fostering a stronger relationship could bring strengths to each.
openaire   +1 more source