Results 91 to 100 of about 32,238 (217)

Ethnic Bridging of Sepiapterin in Chinese and Korean Populations Based on Predictions From Genetic Polymorphism of Breast Cancer Resistance Protein

Clinical and Translational Science, Volume 19, Issue 4, April 2026.
ABSTRACT Ethnic differences are crucial when considering the efficacy, safety, and dose of pharmaceuticals across diverse populations. The International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use (ICH) guideline E5 addresses the acceptability of extrapolating foreign clinical data taking ethnic factors into ...
Lan Gao, Neil Smith, Ronald Kong
wiley   +1 more source

An innovative method for the detection of contaminant viral genome in cell cultures [PDF]

, 2012
The use of cell cultures involves different fields of biology, from diagnosis to research. Moreover, technologies based on animal cells represent a useful tool to the development of biological products for the prophylaxis and therapy in humans and ...
ALTOMARE, Roberta, Cannella, V., DI BELLA, Santina, Di Marco, P., Guercio, A., PURPARI, Giuseppa, Russotto, L.   +6 more
core  

Nanoperforations in poly(lactic acid) free-standing nanomembranes to promote interactions with cell filopodia [PDF]

, 2016
Nanoperforated poly(lactic acid) (PLA) free-standing nanomembranes (FsNMs) have been prepared using a two-step process: (1) spin-coating a mixture of immiscible polymers to provoke phase segregation and formation of appropriated nanofeatures (i.e.
Alemán Llansó, Carlos, Medina Pardell, Judith, Puiggalí Jou, Anna, Valle Mendoza, Luis Javier del   +3 more
core   +2 more sources

Newly identified properties of known pharmaceuticals and myxobacterial small molecules revealed by screening for autophagy modulators

The FEBS Journal, Volume 293, Issue 8, Page 2314-2340, April 2026.
Autophagy is a cellular degradation process involved in, for example, immune responses to pathogens and neurodegeneration. To identify modulators of autophagy, we developed a microscopy‐based screening assay and identified previously unknown autophagy‐modulating activities in known drugs and natural products from myxobacteria and fungi.
Janine Fichtner, Yan Yan Beer, H. G. Mauricio Ramm, Sabrina Mühlen, Frank Surup, Jennifer Herrmann, Toni Luise Meister, Stephanie Pfaender, Ursula Bilitewski, Mark Brönstrup, Rolf Müller, Manfred Wirth, Eeva‐Liisa Eskelinen, Ingo Schmitz   +13 more
wiley   +1 more source

The Effect of Chemical Treatment Conditions of Titanium Dioxide Sols on Their Dispersion and Cytotoxic Properties

Chemical Engineering Transactions, 2012
The effect of neutralization conditions of TiO2 acid sol obtained by hydrolysis of titanium tetraisopropoxide (the nature of monovalent cation (Li+, Na+, NH4+) of electrolyte, chemical nature of a dialyzing solution, and surface modification of ...
Z. Ismagilov, N. Shikina, E. Bessudnova, D.V. Korneev, A.V. Ishchenko, Y.A. Chesalov, A. V. Vladimirova, E. Ryabchikova   +7 more
doaj   +1 more source

Heat shock proteins and the cellular response to osmotic stress [PDF]

, 2000
In antidiuresis, the intrarenal distribution of HSP25/27, alpha beta -crystallin, HSP72, OSP94 and HSP110 corresponds to the osmotic gradient between cortex and papilla: low amounts in the cortex and high values in the inner medulla and papilla.
Beck, Franz-X., Grünbein, Rita, Lugmayr, Karin, Neuhofer, Wolfgang   +3 more
core   +1 more source

Antigen specificity, not tissue compartment, determines clonal sharing among respiratory tract CD8+ resident memory T cells

Immunology &Cell Biology, Volume 104, Issue 4, Page 358-367, April 2026.
Abstract Tissue‐resident memory (Trm) CD8+ T cells in the upper and lower respiratory tract play an instrumental role in combatting influenza virus. While CD8+ Trm populations in these compartments differ in longevity and developmental requirements, it remains unclear whether they share clonotypes, indicating a common origin, or are seeded by distinct ...
Thi H O Nguyen, Hayley A McQuilten, Angela Pizzolla, Sneha Sant, Kim L Harland, Jessica Braverman, Katherine Kedzierska, Linda M Wakim   +7 more
wiley   +1 more source

Parathyroid hormone-stimulated cadmium accumulation in Madin-Darby canine kidney cells

Toxicology and Applied Pharmacology, 1991
Although most renal cadmium transport occurs in proximal tubules indirect evidence suggests that distal tubules may also transport this heavy metal. Since the distal nephron is the site at which parathyroid hormone (PTH) regulates calcium absorption, we evaluated the effects of PTH on Cd2+ accumulation in Madin-Darby canine kidney (MDCK) cells.
J L, Flanagan, P A, Friedman
openaire   +2 more sources

Development and Qualification of a Pseudotyped Virus‐Based Microneutralisation Assay for Influenza D Virus

Influenza and Other Respiratory Viruses, Volume 20, Issue 4, April 2026.
ABSTRACT Background Epidemiological surveillance of influenza D virus (IDV) has gained increased priority following recent serological findings indicating its potential zoonosis in humans. In this context, it is crucial to develop strong, reproducible, reliable and scalable immunological assays that can be quickly implemented in the surveillance of new
Maria Giovanna Marotta, Tobias Mapulanga, Meshach Maina, Janet Daly, Michele Camero, Pauline Mvan Diemen, Helen E. Everett, Emanuele Montomoli, Kelly da Costa, Nigel Temperton, Claudia Maria Trombetta   +10 more
wiley   +1 more source

AMP‐dependent kinase stimulates the expression of αKlotho

FEBS Open Bio
Renal αKlotho along with fibroblast growth factor 23 regulates phosphate and vitamin D metabolism. Its cleavage yields soluble Klotho controlling intracellular processes.
Julia Vogt, Lisa Wolf, Ludwig E. Hoelzle, Martina Feger, Michael Föller   +4 more
doaj   +1 more source