Results 71 to 80 of about 32,238 (217)

Gamma‐irradiated Newcastle disease virus: an alternative inactivated oncolytic virotherapy

Immunology &Cell Biology, Volume 104, Issue 5, Page 473-484, May‐June 2026.
To overcome biological risks associated with using live NDV as an oncolytic therapy, we developed gamma‐NDV as a safer alternative. Using a murine model for skin cancer, we show that intratumor administration of gamma‐NDV outperformed live‐NDV in terms of reducing tumor growth and improving overall animal survival. Abstract Newcastle disease virus (NDV)
Eve V Kennedy, Yimin Chuah, Amal H Mostafa, Chloe J Gates, Jade Foeng, Todd S Norton, Shaun R McColl, Iain Comerford, Justin B Davies, Farhid Hemmatzadeh, Mohammed Alsharifi   +10 more
wiley   +1 more source

A Preclinical Model to Assess Intestinal Barrier Integrity Using Canine Enteroids and Colonoids

Biology
While two-dimensional (2D) cell cultures, such as Caco-2 and Madin–Darby canine kidney (MDCK) cells are widely used in a variety of biological models, these two-dimensional in vitro systems present inherent limitations in replicating the complexities of ...
Megan P. Corbett, Vojtech Gabriel, Vanessa Livania, David Díaz-Regañón, Abigail Ralston, Christopher Zdyrski, Dongjie Liu, Sarah Minkler, Hannah Wickham, Addison Lincoln, Karel Paukner, Todd Atherly, Maria M. Merodio, Dipak Kumar Sahoo, David K. Meyerholz, Karin Allenspach, Jonathan P. Mochel   +16 more
doaj   +1 more source

Distinct susceptibility and applicability of MDCK derivatives for influenza virus research. [PDF]

PLoS ONE, 2017
Madin-Darby Canine Kidney (MDCK) cells are widely utilized as a substrate for influenza virus isolation and propagation due to the high yields of virus.
Shih-Chao Lin, Matthew A Kappes, Mei-Chun Chen, Chi-Chen Lin, Tony T Wang   +4 more
doaj   +1 more source

Liquid flow through monolayers of cultured Madin‐Darby canine kidney cells [PDF]

Experimental Physiology, 1992
The rate of liquid flow per unit area (Jv/A) through Madin‐Darby canine kidney cell monolayers has been studied at temperatures between 0 and 38 degrees C and at transmonolayer hydrostatic pressures between 14 and 44 cmH2O. Jv/A decreased exponentially with time during application of a constant pressure to the free surface of each monolayer.
openaire   +2 more sources

From Mechanisms to Materials: Oximate Reactivity and Emerging Strategies for Organophosphate Detoxification

ChemPhysChem, Volume 27, Issue 7, 14 April 2026.
The development of effective strategies for the detoxification of organophosphorus (OP) nerve agents has evolved from the early mechanistic studies of François Terrier and collaborators, who first elucidated the exceptional nucleophilicity of α‐effect species such as oximes and hydroxamates, to the modern design of supramolecular and material‐based ...
Pedro Rodríguez‐Dafonte
wiley   +1 more source

Transcytosis in MDCK cells: identification of glycoproteins transported bidirectionally between both plasma membrane domains. [PDF]

, 1990
MDCK cells display fluid-phase transcytosis in both directions across the cell. Transcytosis of cell surface molecules was estimated by electron microscopic analysis of streptavidin-gold-labeled frozen sections of biotinylated cells.
Brandli, A. W., Parton, R. G., Simons, K.   +2 more
core   +1 more source

Programmable DNA‐Peptide Hybrid Nanostructures for Potent Neutralization of Multiple Influenza a Virus Subtypes

Advanced Functional Materials, Volume 36, Issue 31, 16 April 2026.
A multivalent antiviral platform based on honeycomb‐shaped DNA nanostructures (HC–Urumin) is developed to enhance the potency and breadth of the host defense peptide Urumin. Through spatially patterned trimeric presentation, HC–Urumin disrupts influenza A virus entry, improves cell viability, and reduces disease severity in vivo‐offering a modular and ...
Saurabh Umrao, Abhisek Dwivedy, Payton L. Haak, Dhanush Gandavadi, Laurie A. Rund, Chi Chen, Vineetha Mareddy, Lifeng Zhou, Jinwei Duan, Ying Fang, Andrew J. Steelman, Xing Wang   +11 more
wiley   +1 more source

Collective cell motion in an epithelial sheet can be quantitatively described by a stochastic interacting particle model. [PDF]

PLoS Computational Biology, 2013
Modelling the displacement of thousands of cells that move in a collective way is required for the simulation and the theoretical analysis of various biological processes.
Néstor Sepúlveda, Laurence Petitjean, Olivier Cochet, Erwan Grasland-Mongrain, Pascal Silberzan, Vincent Hakim   +5 more
doaj   +1 more source

Carbonic Anhydrase Activity in Madin Darby Canine Kidney Cells

Kidney and Blood Pressure Research, 1989
Madin Darby canine kidney (MDCK) renal epithelial cell cultures have been investigated with respect to their potency to express carbonic anhydrase activity using histochemical methods. Acetazolamide inhibitable carbonic anhydrase activity could be detected in the cytoplasmic compartment as well as in the apical membrane of cells when grown on solid ...
Walter Pfaller, Gerhard Gstraunthaler, Ulrich Kersting, Hans Oberleithner   +3 more
openaire   +1 more source

Characterization of cholinergic receptors in Madin-Darby canine kidney cells. [PDF]

Journal of the American Society of Nephrology, 1992
Muscarinic-type cholinergic receptors coupled to the phosphoinositide (PI) second messenger system are reported to be present in the inner medullary collecting duct cells. Madin-Darby canine kidney (MDCK) cells have several characteristics of collecting duct cells and have been shown to respond to muscarinic agonists. To determine if MDCK cells have PI-
D, Mohuczy-Dominiak, L C, Garg
openaire   +2 more sources