Results 71 to 80 of about 19,777 (180)

Benzofuran‐Based Uricosuric Agents: History, Roles, and Challenges

ChemistrySelect, Volume 11, Issue 24, 25 June 2026.
Benzofuran‐based uricosuric agents represent a privileged medicinal chemistry scaffold for gout therapy. Structural optimization of benzbromarone‐related derivatives has improved hURAT1 inhibitory potency, metabolic stability, and urate‐lowering efficacy, while reducing hepatotoxic liability.
Raed M. Al‐Zoubi, Basma Hanbali, Mai Elaarag, Zainab Fares, Enas A. Al‐Hurani, Sally R. Al‐Zoubi, Mohanad Shkoor, Abdelali Agouni   +7 more
wiley   +1 more source

Monoclonal Antibodies 13A4 and AC133 Do Not Recognize the Canine Ortholog of Mouse and Human Stem Cell Antigen Prominin-1 (CD133). [PDF]

PLoS ONE, 2016
The pentaspan membrane glycoprotein prominin-1 (CD133) is widely used in medicine as a cell surface marker of stem and cancer stem cells. It has opened new avenues in stem cell-based regenerative therapy and oncology.
Kristina Thamm, Sylvi Graupner, Carsten Werner, Wieland B Huttner, Denis Corbeil   +4 more
doaj   +1 more source

Streamlined Synthesis and Structure–Activity Relationship Analysis of 2‐Amidothiophene‐3‐Carboxamides Targeting Influenza Polymerase PA‐PB1 Heterodimerization

ChemMedChem, Volume 21, Issue 10, 27 May 2026.
Development of a three‐step synthesis and replacement of the cycloheptyl moiety in cycloheptathiophene‐3‐carboxamide derivatives revealed how thiophene C‐5 substitutions modulate PA–PB1 inhibition, antiviral potency, and water solubility. The phenyl analog 9 delivered sub‐µM potency across multiple IV strains, while the methyl analog 5 achieved the ...
Tommaso Felicetti, Alessia Zago, Andrea Astolfi, Giuseppe Manfroni, Stefano Sabatini, Maria Letizia Barreca, Oriana Tabarrini, Arianna Loregian, Serena Massari   +8 more
wiley   +1 more source

MVP Inhibits Influenza A Virus‐Induced Ferroptosis by Targeting IRF1 and Increasing FSP1 Activity

Advanced Science, Volume 13, Issue 26, 8 May 2026.
During IAV infection, MVP inhibits IRF1 polyubiquitination, thereby relieving IRF1‐mediated transcriptional inhibition of FSP1. Consequently, this leads to an upregulation of FSP1 expression, thereby reinforcing the inhibition of ferroptosis. In addition, the MVP can promote myristoylation and ubiquitination of FSP1, enabling its membrane localization ...
Yingbo Chen, Paili Lin, Yongfang Xia, Zhiqiang Liu, Zilu Cheng, Qingmei Zhu, Shiqi Wan, Xiaoyu Chen, Haiyan Bao, Renbo Qiao, Gechang Zhong, Ying Zhu, Shi Liu   +12 more
wiley   +1 more source

Curated set of tool compounds to probe PYK2 and FAK signaling in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract INTRODUCTION Proline‐rich tyrosine kinase 2 (PYK2) and focal adhesion kinase (FAK) are non‐receptor tyrosine kinases implicated in Alzheimer's disease (AD), but their functional role in microglia remains understudied. Selective pharmacological tools are required for preclinical studies leading to translational therapeutic development.
Pathum M. Weerawarna, Cynthia D. Jesudason, Karen L. Lobb, Emily R. Mason, Xiaoping Gu, Shaoyou Chu, Timothy I Richardson   +6 more
wiley   +1 more source

Cannabinoids and drug–drug pharmacokinetic interactions: Deciphering the risks

British Journal of Clinical Pharmacology, Volume 92, Issue 5, Page 1287-1308, May 2026.
The relationship between cannabinoids and mental health has become a major focus of scientific inquiry and public discourse. Cannabinoids are diverse chemical compounds from the Cannabis species that have been explored for their therapeutic applications in treating chronic pain, psychiatric and neurological conditions, such as depression, schizophrenia,
Paraskevi Papakyriakopoulou, Georgia Valsami, Georgios Ismailos   +2 more
wiley   +1 more source

Anxiolytic and Memory Protective Effects of Withanolide D Isolated From Acnistus arborescens in Adult Zebrafish

Chemistry &Biodiversity, Volume 23, Issue 5, May 2026.
Withanolide D Exhibits Anxiolytic and Memory‐Protective Effects. ABSTRACT This study evaluated the anxiolytic and memory‐protective effects of withanolide D in adult zebrafish (Danio rerio). The compound was administered at doses of 4, 20, and 40 mg/kg and showed no signs of toxicity after 96 h of observation at any of the doses tested.
Cléia Rocha de Sousa Feitosa, Joilna Alves Da Silva, Jéssica Bezerra Maciel, Ivana Carneiro Romão, Thais Rocha Cavalcante, Francisco Anderson Nascimento Barros, Nicole de Abreu Bandeira, Emmanuel Silva Marinho, Jane Eire Silva Alencar De Menezes, Maria Kueirislene Amâncio Ferreira, Antonio Wlisses Da Silva, Márcia Machado Marinho, Matheus Nunes Da Rocha, Otília Deusdênia Loiola Pessoa, Pedro Henrique Jatai Batista, Andreia Ferreira De Castro Gomes, Alexandre Magno Rodrigues Teixeira, Hélcio Silva Dos Santos   +17 more
wiley   +1 more source

The Effect of Chemical Treatment Conditions of Titanium Dioxide Sols on Their Dispersion and Cytotoxic Properties

Chemical Engineering Transactions, 2012
The effect of neutralization conditions of TiO2 acid sol obtained by hydrolysis of titanium tetraisopropoxide (the nature of monovalent cation (Li+, Na+, NH4+) of electrolyte, chemical nature of a dialyzing solution, and surface modification of ...
Z. Ismagilov, N. Shikina, E. Bessudnova, D.V. Korneev, A.V. Ishchenko, Y.A. Chesalov, A. V. Vladimirova, E. Ryabchikova   +7 more
doaj   +1 more source

AMP‐dependent kinase stimulates the expression of αKlotho

FEBS Open Bio
Renal αKlotho along with fibroblast growth factor 23 regulates phosphate and vitamin D metabolism. Its cleavage yields soluble Klotho controlling intracellular processes.
Julia Vogt, Lisa Wolf, Ludwig E. Hoelzle, Martina Feger, Michael Föller   +4 more
doaj   +1 more source

Polarity of neutral glycolipids, gangliosides, and sulfated lipids in MDCK epithelial cells.

Journal of Lipid Research, 1988
Confluent monolayers of MDCK (Madin-Darby canine kidney) cells provide a widely used model system for studying epithelial cell polarity. We determined the polarity of epithelial cell plasma membrane glycolipids and sulfated lipids by analyzing the lipids
G E Nichols, T Shiraishi, W W Young, Jr
doaj   +1 more source