Results 111 to 120 of about 2,755,275 (260)

Aspartic Protease Inhibition Induces Proteomic Remodeling in Paracoccidioides brasiliensis

open access: yesPROTEOMICS, EarlyView.
ABSTRACT Paracoccidioidomycosis (PCM) is a major systemic mycosis in Latin America caused by Paracoccidioides brasiliensis, yet the contribution of aspartic proteases to fungal physiology and pathogenicity remains poorly understood. Here, we employed data‐independent acquisition (DIA)‐based quantitative proteomics to investigate the impact of pepstatin
Sarah Fernandes Lima   +6 more
wiley   +1 more source

Type I MADS-box genes have experienced faster birth-and-death evolution than type II MADS-box genes in angiosperms

open access: yes, 2018
Plant MADS-box genes form a large gene family for transcription factors and are involved in various aspects of developmental processes, including flower development.
Kim, J   +5 more
core   +1 more source

QSP Modeling Shows Pathological Synergism Between Insulin Resistance and Amyloid‐Beta Exposure in Upregulating VCAM1 Expression at the BBB Endothelium

open access: yesCPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 561-571, March 2025.
ABSTRACT Type 2 diabetes mellitus (T2DM), characterized by insulin resistance, is closely associated with Alzheimer's disease (AD). Cerebrovascular dysfunction is manifested in both T2DM and AD, and is often considered as a pathological link between the two diseases.
Zengtao Wang   +6 more
wiley   +1 more source

Comparative Genomics and Functional Evidence for Convergent Adaptation to Hypoxia in Mammals

open access: yesIntegrative Zoology, EarlyView.
This study reveals convergent selection in mammals adapted to hypoxia. Functional assays demonstrate that amino acid mutations reduce oxidative stress, attenuate hypoxia‐induced injury, and modulate the hypoxia‐inducible transcription factor (HIF)‐driven hypoxic response.
Hao Dong   +5 more
wiley   +1 more source

From LiDAR point clouds to 3D tree morphometrics: New approach to quantitatively evaluate tree shapes

open access: yesMethods in Ecology and Evolution, EarlyView.
Abstract Tree crowns are complex, three‐dimensional structures whose morphology varies among species, individuals and environments. Although light detection and ranging (LiDAR) provides high‐resolution, single‐tree point clouds that advance species discrimination and the assessment of intraspecific variation in situ, crown shape is still commonly ...
Ladislav Hodač   +5 more
wiley   +1 more source

Number of annotated MADS-box genes present in genomes.

open access: yes, 2019
Number of annotated MADS-box genes present in genomes.
Bingying Han (3178617)   +7 more
core   +1 more source

Human Recreation and Fire History Shape Landscape Connectivity for an Endangered Forest Carnivore

open access: yesAnimal Conservation, EarlyView.
Roads and trails can impede wildlife movement, but their permeability varies with human use and fire history. We combined GPS telemetry from 45 endangered southern Sierra Nevada fishers (Pekania pennanti) with smartphone‐derived human mobility data to estimate crossing probability across road and trail segments. Fishers were about 2.5 times more likely
Mark A. Ditmer   +11 more
wiley   +1 more source

Non‐Alzheimer Aβ deposits in the human CNS: Implications with hypoxia and related conditions

open access: yesBrain Pathology, EarlyView.
An Aβ deposit in a non‐Alzheimer's brain from an individual who experienced hypoxia/energy failure. Abstract We recently reported the deposition of Aβ in the frontal cortex of individuals who died of acute coronavirus disease 2019 (COVID‐19), or who did not have COVID‐19 but had respiratory distress, or infants with severe cardiac malformations.
Esma Karlovich   +5 more
wiley   +1 more source

Intragenic Control of Expression of a Rice MADS Box Gene OsMADS1

open access: yesMolecules and Cells, 2008
OsMADS1 is a rice MADS box gene necessary for floral development. To identify the key cis-regulatory regions for its expression, we utilized transgenic rice plants expressing GUS fusion constructs. Histochemical analysis revealed that the 5.7-kb OsMADS1 intragenic sequences, encompassing exon 1, intron 1, and a part of exon 2, together with the 1.9-kb ...
Jeon, JS, Lee, S, An, G
openaire   +2 more sources

“The Liminal Father”: A qualitative study exploring men's experiences of paternal imprisonment

open access: yesFamily Relations, EarlyView.
Abstract Objective This study explored the lived experience of growing up with an imprisoned father, from the adult sons' perspectives. Background Previous research has shown that paternal imprisonment has a significant impact on the emotional well‐being of the sons left behind.
Senan Tuohy‐Hamill   +2 more
wiley   +1 more source

Home - About - Disclaimer - Privacy