Results 221 to 230 of about 32,559 (283)

Gemcitabine activates the Hippo signaling pathway and suppresses tumor growth by stabilizing large tumor suppressor kinase 2 through the hypoxia‐inducible factor 1‐alpha/ubiquitin protein ligase E3 component N‐recognin 5 axis

open access: yesJournal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.
Abstract To investigate the molecular mechanism by which gemcitabine (GEM) inhibits ovarian cancer (OC) progression, focusing on the hypoxia‐inducible factor 1‐alpha (HIF1A)/UBR5/LATS2 axis and Hippo pathway. Bioinformatics analysis of gene expression omnibus datasets identified HIF1A‐associated modules.
Jin Zhang   +5 more
wiley   +1 more source

Shifting Balancing Selection Underlies an Inversion Cline in Eurasian Blackcap

open access: yesEcology and Evolution, Volume 16, Issue 6, June 2026.
We investigated what factor contributes to a cline of a chromosomal inversion of the Eurasian blackcap, which differs from typical inversion clines maintained by divergent selection. Using a simulation‐based machine learning approach, we found that the inversion is under negative frequency‐dependent selection, and the optimal frequency is shifted ...
Jun Ishigohoka, Miriam Liedvogel
wiley   +1 more source

Females Fly Further—Sex‐Specific and Seasonal Differences in Migration Patterns of Pied Avocets

open access: yesEcology and Evolution, Volume 16, Issue 6, June 2026.
GPS tracking of 122 pied avocets revealed pronounced sex‐ and season‐specific migration strategies, with females migrating further than males, while spring migration was faster and more fragmented than autumn migration. Avocets spent a substantial part of their annual cycle in the Wadden Sea during the post‐breeding period before starting migration to ...
Mads Eskildsen   +7 more
wiley   +1 more source

Hemoglobin Digestion Genes Are Conserved in Lizard‐Infective Plasmodium Species With Different Host Cellular Niches

open access: yesEcology and Evolution, Volume 16, Issue 6, June 2026.
Despite their evolutionary relatedness to malaria parasites that infect humans, wildlife Plasmodium—particularly those that infect birds and lizards—are understudied, leaving their vast genetic diversity to be explored. By assembling parasite transcriptomes from Plasmodium‐infected lizard blood, we provide the first evidence that lizard‐infective ...
Sarah J. Pangburn   +4 more
wiley   +1 more source

”Not always the magic bullet”—Insufficient seizure control by ketogenic dietary therapies in Glut1 Deficiency Syndrome

open access: yesEpilepsia Open, Volume 11, Issue 3, Page 847-858, June 2026.
Abstract Objective Ketogenic dietary therapies (KDTs) are the treatment of choice for Glut1 Deficiency Syndrome (Glut1DS), providing dietary ketones as an alternative fuel to the brain and effectively controlling seizures. Recent evidence indicates insufficient seizure control in Glut1DS patients despite adequate KDT and ketosis.
Joerg Klepper, Eva Runkel, Lucia Kiesel
wiley   +1 more source

Real‐world, multi‐omics validation of the clinical relevance of molecular taxonomy for myelodysplastic syndromes (MDS)

open access: yesHemaSphere, Volume 10, Issue 6, June 2026.
Abstract Myelodysplastic syndromes (MDS) are clinically and biologically diverse disorders, emphasizing the need for personalized treatment approaches. The International Working Group for Prognostication of MDS (IWG_PM) recently introduced a molecular classification, referred to as the MDS taxonomy, that categorizes patients into 16 subgroups based on ...
Giulia Maggioni   +90 more
wiley   +1 more source

Fraxinus excelsior updated long-read genome reveals the importance of MADS-box genes in tolerance mechanisms against ash dieback

open access: yes
Franco Ortega S   +8 more
europepmc   +1 more source

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