Results 81 to 90 of about 11,780 (226)

Comparative Genomics and Functional Evidence for Convergent Adaptation to Hypoxia in Mammals

Integrative Zoology, EarlyView.
This study reveals convergent selection in mammals adapted to hypoxia. Functional assays demonstrate that amino acid mutations reduce oxidative stress, attenuate hypoxia‐induced injury, and modulate the hypoxia‐inducible transcription factor (HIF)‐driven hypoxic response.
Hao Dong, Chunxu Wang, Enqing Pei, Liang Zhao, Simin Chai, Ran Tian   +5 more
wiley   +1 more source

Non‐Alzheimer Aβ deposits in the human CNS: Implications with hypoxia and related conditions

Brain Pathology, EarlyView.
An Aβ deposit in a non‐Alzheimer's brain from an individual who experienced hypoxia/energy failure. Abstract We recently reported the deposition of Aβ in the frontal cortex of individuals who died of acute coronavirus disease 2019 (COVID‐19), or who did not have COVID‐19 but had respiratory distress, or infants with severe cardiac malformations.
Esma Karlovich, David S. Priemer, Charles Harker Rhodes, Daniel P. Perl, Kurenai Tanji, James E. Goldman   +5 more
wiley   +1 more source

Characterization and Phylogenetic Analysis of MADS-Box Gene Family in Magnoliids: Insights into the Evolution of Floral Morphogenesis in Angiosperms

Plants
Magnoliids represent one of the most basal lineages within angiosperms, and their ancestral floral morphology provides crucial insights into the evolution of flowers in angiosperms. MCM1-AGAMOUS-DEFICIENS-SRF (MADS)-box transcription factors play crucial
Haowei Chen, Haoyue Qu, Junmei Zhou, Junjie Pan, Zhoutao Wang, Liangsheng Zhang, Xiuxiu Li, Kejun Cheng   +7 more
doaj   +1 more source

“The Liminal Father”: A qualitative study exploring men's experiences of paternal imprisonment

Family Relations, EarlyView.
Abstract Objective This study explored the lived experience of growing up with an imprisoned father, from the adult sons' perspectives. Background Previous research has shown that paternal imprisonment has a significant impact on the emotional well‐being of the sons left behind.
Senan Tuohy‐Hamill, John O'Connor, Paul Murphy   +2 more
wiley   +1 more source

Functional Analysis of MADS-Box Gene Family in Stress Response and Prospects of Breeding Application

Plants
The MADS-box family is a multifunctional family of transcription factors characterized by the presence of a unique MADS domain, which plays an important part in regulating essential biological processes, including metabolic synthesis and the stress ...
Jiaxuan Wang, Hongying Wang, Mengyao Li, Yujie Chen, Bingyan Song, Yingying Li, Xuhui Meng, Jie Li, Wenting Lu, Yi Gao, Yao Zhang, Aoxue Wang   +11 more
doaj   +1 more source

RAB4A acts as a negative feedback regulator of extracellular vesicle secretion during TGF‐β signaling

The FEBS Journal, EarlyView.
TGF‐β signaling regulates extracellular vesicle (EV) release in cancer cells by modulating the expression and activity of genes associated with EV biogenesis. The TGF‐β‐induced upregulation of RAB4A expression facilitates fast endosomal recycling, a process that limits the fusion of multivesicular bodies with the plasma membrane and EV secretion. Hence,
Dorival Mendes Rodrigues‐Junior, Maria Anastasia Doumani, Hao Fu, Jelle van den Bor, Olof Idevall‐Hagren, Aristidis Moustakas   +5 more
wiley   +1 more source

Iloperidone treatment mitigates the Juvenile Huntington's Disease phenotype possibly via Sigma‐1 Receptor Modulation

The FEBS Journal, EarlyView.
We investigated the potential of iloperidone as an activator of Sigma‐1 receptor (S1R) neuroprotective function in juvenile Huntington's disease (jHD). We tested iloperidone on cortical neurons differentiated from patient‐derived iPSCs, demonstrating that it acts as a S1R agonist, decreasing apoptosis, huntingtin aggregation, and oxidative stress ...
Ersilia Fornetti, Gaia Galluzzi, Mario Frezzini, Cécile Exertier, Vittorio Brufani, Gianni Colotti, Giancarlo Ruocco, Jessica Rosati, Angelo Luigi Vescovi, Daniele Narzi, Ilaria Genovese, Andrea Ilari   +11 more
wiley   +1 more source

Thermal Thresholds and Genetic Sensitivity in Barrel Racing Performance of Quarter Horses Across Temperature–Humidity Indices

Journal of Animal Breeding and Genetics, EarlyView.
ABSTRACT Heat stress is an increasingly important challenge for the performance and welfare of equine athletes, particularly in competitions conducted across diverse climatic conditions. Understanding the genetic basis of performance responses to increasing thermal load is therefore essential to support robust genetic evaluation and sustainable ...
Mário Luiz Santana, Annaiza Braga Bignardi   +1 more
wiley   +1 more source

MADS-box gene expression patterns correlate with drought and salt stress responses in Kentucky bluegrass (Poa pratensis L.) [PDF]

PeerJ
Background Kentucky bluegrass (Poa pratensis L.) is a perennial cool-season turfgrass commonly utilized in lawns. However, turfgrass quality is affected by abiotic stress.
Komal Tariq, Xue You, Yifeng Jin, Haoran Yu, Sabir Iqbal, Adil Hussain, Yang Chen   +6 more
doaj   +2 more sources

Cryptic diversity and recent diversification in the Pyrrhulina australis species complex (Characiformes, Lebiasinidae) revealed by mitochondrial DNA

Journal of Fish Biology, EarlyView.
Abstract Pyrrhulina australis Eigenmann & Kennedy, 1903, is widely distributed across the main hydrographic basins of South America. The taxonomic integrity of this species is nevertheless challenged by the lack of clear diagnostic characters, its marked geographic variation and the morphological overlap with its congeners. In this context, the present
Taina Barbosa De Souza, Daniela Cristina Ferreira, Hugmar Pains Da Silva, Carolina B. Machado, Claudio Oliveira, André L. Netto‐Ferreira, Paulo C. Venere   +6 more
wiley   +1 more source