Results 71 to 80 of about 118,614 (242)

ZmMADS47 Regulates Zein Gene Transcription through Interaction with Opaque2. [PDF]

PLoS Genetics, 2016
Zeins, the predominent storage proteins in maize endosperm, are encoded by multiple genes and gene families. However, only a few transcriptional factors for zein gene regulation have been functionally characterized.
Zhenyi Qiao, Weiwei Qi, Qian Wang, Ya'nan Feng, Qing Yang, Nan Zhang, Shanshan Wang, Yuanping Tang, Rentao Song   +8 more
doaj   +1 more source

Simulating neutron protein crystallography experiments: applications to the development of the NMX instrument at ESS

Acta Crystallographica Section D, EarlyView.
Monte Carlo simulations of neutron protein diffraction experiments provide useful data that models neutrons interacting with instrument components, as well as the crystal diffraction itself. These data can be applied to instrument development, such as the commissioning of the NMX Macromolecular Diffractometer at ESS.Monte Carlo neutron ray‐tracing ...
Mads Bertelsen, Peter K. Willendrup, Sunyoung Yoo, Adriano Meligrana, David McDonagh, Justin Bergmann, Esko Oksanen, Aaron D. Finke   +7 more
wiley   +1 more source

Ultrasound, PET/CT or temporal artery biopsy for giant cell arteritis? A prospective diagnostic accuracy study (the GAME‐study)

Acta Ophthalmologica, EarlyView.
Abstract Purpose To investigate the diagnostic performance of ultrasound, 2‐deoxy‐2‐[18F]fluoro‐D‐glucose positron emission tomography/computed tomography (2‐[18F]FDG PET/CT) and temporal artery biopsy (TAB) in giant cell arteritis (GCA). Methods This was a prospective single‐centre diagnostic accuracy study (ClinicalTrials.gov NCT05248906).
Michael S. Hansen, Lene Terslev, Uffe M. Døhn, Viktoria Fana, Jane M. Brittain, Anne K. Wiencke, Steffen Heegaard, Mads R. Jensen, Oliver N. Klefter, Yousif Subhi, Steffen Hamann   +10 more
wiley   +1 more source

Developmental and evolutionary diversity of plant MADS-domain factors: insights from recent studies [PDF]

, 2012
Members of the MADS-box transcription factor family play essential roles in almost every developmental process in plants. Many MADS-box genes have conserved functions across the flowering plants, but some have acquired novel functions in specific species
Angenent, G.C., Smaczniak, C., Immink, R.G.H., Kaufmann, K.   +3 more
core   +1 more source

Data‐driven thresholds for standardized classification of severe Alzheimer's disease neuropathology using digital neuropathology

Brain Pathology, EarlyView.
We generated digital pathologic algorithms (AI‐based modules that can be freely shared) to: optimize the sampling (ROI) for diagnosis of ADNC‐related tau pathology; compare/transition between Aperio and HALO platforms; and rationalize severe Braak NFT staging, so that all Braak‐VI cases had dementia, and all Braak‐V cases had MCI or dementia.
Ryan K. Shahidehpour, Allison M. Neltner, Mitchell A. Klusty, Cole Corbett, Angelique D. Gonzalez, David A. Gutman, David W. Fardo, Adam D. Bachstetter, Cody Bumgardner, Margaret E. Flanagan, Peter T. Nelson   +10 more
wiley   +1 more source

Targeting protein–protein interactions with reversible covalent modalities: Non‐cysteine chemistries

British Journal of Pharmacology, EarlyView.
Abstract Protein–protein interactions (PPIs) are central to diverse cellular functions, and represent a rapidly expanding class of therapeutic targets. Advancements in covalent drug design have enabled small‐molecule drugs to overcome challenges associated with engaging these targets, such as limited durations of action and difficult‐to‐drug (expansive,
Ruchira Basu, Steven Fletcher
wiley   +1 more source

Targeting the noncatalytic activity of GSK3β modulates neuronal excitability in medium spiny neurons via Nav1.6 interactions

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Kinases phosphorylate ion channels, but their noncatalytic roles via protein–protein interactions (PPI) are less understood. Here, we identified the peptidomimetic ZL141 to characterize the PPI between GSK3β and Nav1.6, revealing a noncatalytic role for GSK3β in regulating Nav1.6 currents and neuronal excitability ...
Aditya K. Singh, Zahra Haghighijoo, Akanksha Gurtu, Nolan M. Dvorak, Timothy J. Baumgartner, Nana A. Goode, Jully Singh, Matteo Bernabucci, Adam T. Szafran, Michael J. Bolt, Michael A. Mancini, Natalie M. Dvorak, Marijn Lijffijt, Zhiqing Liu, Yu Xue, Alyssa K. Thomas, Alejandro Villasante‐Tezanos, Balaji Krishnan, Jia Zhou, Fernanda Laezza   +19 more
wiley   +1 more source

MADS on the move : a study on MADS domain protein function and movement during floral development in Arabidopsis thaliana

, 2010
In this thesis we investigated the behaviour of fluorescently-tagged MADS domain proteins during floral development in the model plant Arabidopsis thaliana, and explored the importance of intercellular transport via plasmodesmata for MADS domain ...
Urbanus, S.L.
core  

Structural and functional analyses of PAS domain interactions of the clock proteins Drosophila PERIOD and mouse PERIOD2 [PDF]

, 2009
PERIOD proteins are central components of the Drosophila and mammalian circadian clocks. The crystal structure of a Drosophila PERIOD (dPER) fragment comprising two PER-ARNT-SIM (PAS) domains (PAS-A and PAS-B) and two additional C-terminal alpha-helices (
Strauss, Holger M, Wolf, Eva, Schulze, Sabrina, Sven Hennig, Arens, J., Hennig, Sven; id_orcid, Yildiz, O., Strauss, Holger M., Holger M Strauss, Julia Arens, Kramer, Achim, Arens, Julia, Sabrina Schulze, Schulze, S., Eva Wolf, Vanselow, Katja, Yildiz, Özkan, Katja Vanselow, Strauss, H., Hennig, S., Kramer, A., Vanselow, K., Wolf, E., Strauss, H. M., Achim Kramer, Ozkan Yildiz, Hennig, Sven   +26 more
core   +1 more source

Plant Domestication Affects the Oviposition Behavior and Performance of Ganaspis kimorum, a Parasitoid of Drosophila suzukii

Entomologia Experimentalis et Applicata, EarlyView.
In this study, we investigated the effects of blueberry domestication on the oviposition behavior and performance of Ganaspis kimorum, a parasitoid of Drosophila suzukii. Domestication of blueberries reduced the oviposition‐searching behavior of the parasitoid but enhanced parasitoid performance, including offspring performance. Additionally, blueberry
Yahel Ben‐Zvi, Cesar Rodriguez‐Saona
wiley   +1 more source