Results 91 to 100 of about 764,832 (295)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

open access: yesFEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon   +6 more
wiley   +1 more source

"Maestro e inventor". Vivencias de un maestro nacional

open access: yesCabás, 2011
"Maestro e invertor". Vivencias de un maestro nacional.
José Luis Calderón Fernández
doaj  

Radio astronomy Explorer-B in-flight mission control system development effort [PDF]

open access: yes
A description is given of the development for the Mission Analysis Evaluation and Space Trajectory Operations (MAESTRO) program to be used for the in-flight decision making process during the translunar and lunar orbit adjustment phases of the flight of ...
Bjorkman, W. S.   +2 more
core   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

open access: yesFEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

MAESTRO, CASTRO, and SEDONA -- Petascale Codes for Astrophysical Applications

open access: yes, 2010
Performing high-resolution, high-fidelity, three-dimensional simulations of Type Ia supernovae (SNe Ia) requires not only algorithms that accurately represent the correct physics, but also codes that effectively harness the resources of the most powerful
Almgren, A.   +8 more
core  

Cofradías sufíes senegalesas en contextos migratorios: espacios religiosos transnacionales para la reproducción de identidades [PDF]

open access: yes, 2011
En el debate actual sobre globalización y procesos de construcción y reafirmación de identidades, el papel de la religión es constantemente puesto sobre la mesa. Así, las transformaciones en lo religioso no han dejado indiferentes a las ciencias sociales,
Moreno Maestro, Susana
core  

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

open access: yesFEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold   +11 more
wiley   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

open access: yesFEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti   +3 more
wiley   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

open access: yesFEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart   +7 more
wiley   +1 more source

La mujer, ¿una alternativa ética?: una perspectiva antropológica [PDF]

open access: yes, 2010
Grupo de Investigación en Estructura, Historia y Contenidos de la Comunicación.
Moreno Maestro, Susana
core  

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