Results 71 to 80 of about 113,829 (310)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Entrevista maestro Alexander Amézquita

open access: yes, 2019
Maestro en Artes musicales con énfasis en Arreglos y Composición de la facultad de artes de la Universidad Distrital, saxofonista y Director coral y orquestal.
Carlos, Edwin
core  

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant   +11 more
wiley   +1 more source

Provincia de Chaco : plan maestro cuidad río

open access: yes, 2017
El Ministerio de Infraestructura y Servicios Públicos de la Provincia del Chaco puso en marcha el Plan Maestro Ciudad Río con el propósito de desarrollar el territorio del valle del río Negro y su sistema lacustre de manera inclusiva, integral y ...
Echezarreta, Humberto Fabián   +4 more
core  

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

open access: yesFEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa   +2 more
wiley   +1 more source

Modelos de maestro

open access: yes, 2010
Se presentan los modelos metafóricos de ...
Peiró i Gregòri, Salvador
core  

Measurement of the D0−D¯0${D^0} - {mathop Dlimits^ ^0}$ mixing at CDF

open access: yes, 2013
We report on the observation of D0−D¯0${D^0} - {mathop Dlimits^ ^0}$ oscillations by measuring the time-dependent ratio of yields for the rare decay D0 → K+π− to the favored decay D0 → K−π+ at the Collider Detector at Fermilab (CDF).
Maestro, P.   +2 more
core   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel   +4 more
wiley   +1 more source

Fotografías del Maestro Vanilton Lakka

open access: yes, 2017
Puesta en Escena del Maestro Vanilton Lakka con Sujeto Corpóreo ,Cuerpo ...
Ramirez Lakhovsky, Alejandro
core  

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