Results 111 to 120 of about 764,832 (295)
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Revista de Psicología, 1998 Se comparó el desempeño en lectura evaluada a través de una prueba estandarizada, con la evaluación realizada por los maestros, calculándose el grado de acuerdo entre ambas, en una muestra de 520 niños de escuela básica, en Caracas, Venezuela.
Lydia Pujol, Eleonora Vivas
doaj
Revista Brasileira de História da EducaçãoEl artículo se encarrila en un campo de investigación que busca dilucidar por casos particulares como se tejieron las relaciones entre las escuelas Láinez y las comunidades locales.
Adrian Cammarota
doaj +1 more source
Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment
Aging and Cancer, EarlyView.Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey +12 more
wiley +1 more source
El trabajo investigativo: un modo emergente de subjetivación de los maestros en la escuela
Educación y CiudadEl presente artículo de reflexión aborda la historia de la red pedagógica “Maestros en Colectivo”, para describir cómo el quehacer investigativo se ha naturalizado, en los discursos y las prácticas pedagógicas.
Óscar Leonardo Cárdenas-Forero +1 more
doaj +1 more source
Aging and Cancer, EarlyView.Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu +8 more
wiley +1 more source
Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz +3 more
wiley +1 more source
Currículo y contexto: andamios para la concienciación
TrenzarEn el análisis de la acción del maestro surge la necesidad de examinar de qué manera su labor en el contexto educativo permea las dinámicas sociales y culturales, teniendo en cuenta el planteamiento acerca de la labor docente en calidad de sujeto ...
Adriana María Arrubla Castaño +1 more
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao +6 more
wiley +1 more source
ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan +9 more
wiley +1 more source