Results 201 to 210 of about 183,970 (268)

Mediation of Polygenic Asthma Risk Through Gene Expression

Allergy, EarlyView.
We apply published PRSs in African‐ancestry individuals and quantify the extent to which the PRS‐asthma relationship is mediated by clinical biomarkers and gene‐expression signatures of asthma. We found the best PRS to be the one derived using the largest sample size and including African‐ancestry individuals.
Rakesh Natarajan, Brooke Szczesny, Kanika Kanchan, Erika Esquinca, Meher Preethi Boorgula, Sameer Chavan, Monica Campbell, Wendy Lorizio, Ayo P. Doumatey, Alvaro A. Cruz, Harold Watson, Edward T. Naureckas, B. Louise Giles, Ganiyu Arinola, Olumide Sogaolu, Adegoke G. Falade, Nadia N. Hansel, Christopher O. Olopade, Charles N. Rotimi, R. Clive Landis, Camila A. Figueiredo, Eimear E. Kenny, Ingo Ruczinski, Andrew H. Liu, Carole Ober, Margaret A. Taub, Randi K. Johnson, Kathleen C. Barnes, Genevieve L. Wojcik, Rasika A. Mathias   +29 more
wiley   +1 more source

The closed nutrient recycling system in the <i>Paramecium</i>-<i>Chlorella</i> photosymbiosis contributes to survival under oligotrophic conditions. [PDF]

Sci Adv
Okada K, Fujiwara T, Hirooka S, Kobayashi Y, Onuma R, Miyagishima SY.   +5 more
europepmc   +1 more source

Hemocompatibility and Long‐Term Outcomes in HeartWare Versus HeartMate II Versus HeartMate 3: Multicenter Real‐World Cohort

Artificial Organs, EarlyView.
Multicenter real‐world cohort (n = 327) comparing LVADs: HeartMate 3 (HM3), HeartMate II (HMII), and HeartWare (HVAD). HM3 showed superior long‐term survival versus legacy devices, driven by fewer hemocompatibility‐related adverse events, especially pump thrombosis and ischemic stroke, while major bleeding was similar across devices.
Hamza H. H. Ben Nasir, Ahmed F. A. Mohammed, Omar Allham, Alish Kolashov, Yusuf Shieba, Lachmandath Tewarie, Bernd Panholzer, Ajay Moza, Assad Haneya, Rashad Zayat   +9 more
wiley   +1 more source

Exploring the histopathological signature of repeat‐mediated Fuchs endothelial corneal dystrophy

Acta Ophthalmologica, EarlyView.
Abstract Purpose To determine the histological differences between Fuchs endothelial corneal dystrophy (FECD) cases with and without the most common genetic risk factor, expansion of a CTG repeat (CTG18.1) within the TCF4 gene. Methods Formalin‐fixed paraffin‐embedded corneal tissues were compared retrospectively, and CTG18.1 status was determined from
Anne‐Marie S. Kladny, Nihar Bhattacharyya, Marcos Abreu Costa, Stephen J. Tuft, Caroline Thaung, Alice E. Davidson   +5 more
wiley   +1 more source

Refining Tumor Mutational Burden as a Predictive Biomarker for Pembrolizumab: A Real‐World Analysis in Japanese Patients

Cancer Science, EarlyView.
In this study, we investigated the predictive value of tumor mutational burden (TMB) for assessing the efficacy of pembrolizumab in a Japanese cohort. We analyzed real‐world data from 63,952 patients registered in the C‐CAT database who underwent comprehensive genomic profiling, and evaluated the therapeutic efficacy of pembrolizumab in 1899 of these ...
Tomoyo Yasuda, Mio Yumura, Azusa Hamasaki, Tongyi Fei, Takashi Kubo, Hitoshi Ichikawa, Takashi Kohno, Kuniko Sunami   +7 more
wiley   +1 more source

Estimation and mapping of the missing heritability of human phenotypes. [PDF]

Nature
Wainschtein P, Zhang Y, Schwartzentruber J, Kassam I, Sidorenko J, Fiziev PP, Wang H, McRae J, Border R, Zaitlen N, Sankararaman S, Goddard ME, Zeng J, Visscher PM, Farh KK, Yengo L.   +15 more
europepmc   +1 more source

Shared and distinct responses of human and murine alveolar macrophages and monocyte-derived macrophages to Mycobacterium tuberculosis. [PDF]

Immunohorizons
Dill-McFarland KA, Peterson G, Lim PN, Skerrett S, Hawn TR, Rothchild AC, Campo M.   +6 more
europepmc   +1 more source

AllergoOncology in Review: Harnessing Allergy in the Field of Oncology to Improve Patient Outcomes

Clinical &Experimental Allergy, EarlyView.
ABSTRACT The AllergoOncology field brings together the study of allergic and cancer immune responses, having evolved from early epidemiological studies that reported inverse associations between allergies, IgE and cancer risk. Insights from studying allergic inflammation are revealing previously unappreciated immune mechanisms that confer protective ...
Jakub Zydron, Anishaa Balaji, Jitesh Chauhan, Jack Alder, Xinyi Chen, Anna M. F. Wiegman, Aurelie Poli, Joanna Jacków‐Malinowska, Jack Cheeseman, Daniel I. R. Spencer, James McDonnell, James Spicer, Alexandra J. McCraw, Sophia N. Karagiannis   +13 more
wiley   +1 more source

Genetic variations in extracellular matrix degradation pathways linking to major depressive disorder: Evidence from a large-scale genetic association study. [PDF]

Biomedicine (Taipei)
Zailani H, Chen DT, Lin SC, Lee JH, Li ML, Chang JP, Su KP.   +6 more
europepmc   +1 more source

Children's Intimate Partner Violence Exposure and Mothers' Eviction Stress

Child &Family Social Work, EarlyView.
ABSTRACT Intimate partner violence has profound impacts on the housing insecurity of mothers and children. Abusers may control household finances, cause property damage or nuisance complaints, or create financial dependence that prevents survivors from fleeing.
Kathryn Showalter, Katherine Marcal, Lijian Zhao, Kathryn Maguire‐Jack, Yanghyun Park, Yinqi Chen   +5 more
wiley   +1 more source