c-MAF, a Swiss Army Knife for Tolerance in Lymphocytes [PDF]
Frontiers in Immunology, 2020 Beyond its well-admitted role in development and organogenesis, it is now clear that the transcription factor c-Maf has owned its place in the realm of immune-related transcription factors.
Claire Imbratta +3 more
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Transcription factor c-Maf: a checkpoint that programs autoimmunity [PDF]
Frontiers in ImmunologyThe transcription factor c-Maf, a member of the Maf family characterized by its basic domain and b-Zip DNA-binding motif, is a pivotal regulator of immune cells development and function.
Na Liu +10 more
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The Enigmatic Emerging Role of the C-Maf Inducing Protein in Cancer [PDF]
Diagnostics, 2021 The C-Maf-Inducing protein (CMIP) was first described as overexpressed in T cell subpopulations of idiopathic nephrotic syndrome (INS) patients. Later, it was found concomitantly upregulated in podocytes. CMIP expression has also been reported in several
Mario Ollero, Dil Sahali
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Transcription factor c-Maf deletion improves streptozotocin-induced diabetic nephropathy by directly regulating Sglt2 and Glut2 [PDF]
JCI Insight, 2023 The transcription factor c-Maf has been widely studied and has been reported to play a critical role in embryonic kidney development; however, the postnatal functions of c-Maf in adult kidneys remain unknown as c-Maf–null C57BL/6J mice exhibit embryonic ...
Mitsunori Fujino +8 more
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Inhibition of the Otub1/c-Maf axis by the herbal acevaltrate induces myeloma cell apoptosis [PDF]
Cell Communication and Signaling, 2021 Background The oncogenic transcript factor c-Maf is stabilized by the deubiquitinase Otub1 and promotes myeloma cell proliferation and confers to chemoresistance.
Tong Sun +7 more
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c-Maf: a bad influence in the education of macrophages. [PDF]
J Clin Invest, 2020 Tumor-associated macrophages (TAMs) represent the most abundant hematopoietic cell type in the solid tumor microenvironment. TAMs drive T cell inhibition, promote angiogenesis, and produce tumor growth factors. Although they can paradoxically exert antitumor activity and prime protective immunity, the pathways driving this phenotype remain unclear.
Conejo-Garcia JR, Rodriguez PC.
europepmc +4 more sources
c-Maf-positive spinal cord neurons are critical elements of a dorsal horn circuit for mechanical hypersensitivity in neuropathy [PDF]
Cell Reports, 2023 Summary: Corticospinal tract (CST) neurons innervate the deep spinal dorsal horn to sustain chronic neuropathic pain. The majority of neurons targeted by the CST are interneurons expressing the transcription factor c-Maf.
Noémie Frezel +12 more
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Targeting the Liquid–Liquid Separation Region of c‐Maf for Treating Chromosomal Translocations in Multiple Myeloma [PDF]
MedCommMultiple myeloma (MM), as an incurable hematologic malignancy, is driven by chromosomal translocations. Recent research suggests that targeting phase separation may offer a new therapeutic vulnerability for MM.
Ze Wang +11 more
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Reciprocal regulation of C-Maf tyrosine phosphorylation by Tec and Ptpn22. [PDF]
PLoS ONE, 2015 C-Maf plays an important role in regulating cytokine production in TH cells. Its transactivation of IL-4 is optimized by phosphorylation at Tyr21, Tyr92, and Tyr131. However, the molecular mechanism regulating its tyrosine phosphorylation remains unknown.
Chih-Chun Liu +9 more
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B cell c-Maf signaling promotes tumor progression in animal models of pancreatic cancer and melanoma [PDF]
Journal for ImmunoTherapy of CancerBackground The role of B cells in antitumor immunity remains controversial, with studies suggesting the protumor and antitumor activity. This controversy may be due to the heterogeneity in B cell populations, as the balance among the subtypes may impact ...
Hong Li +8 more
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