Transcription factor c-Maf deletion improves streptozotocin-induced diabetic nephropathy by directly regulating Sglt2 and Glut2 [PDF]
JCI Insight, 2023 The transcription factor c-Maf has been widely studied and has been reported to play a critical role in embryonic kidney development; however, the postnatal functions of c-Maf in adult kidneys remain unknown as c-Maf–null C57BL/6J mice exhibit embryonic ...
Mitsunori Fujino +8 more
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c-Maf-positive spinal cord neurons are critical elements of a dorsal horn circuit for mechanical hypersensitivity in neuropathy [PDF]
Cell Reports, 2023 Summary: Corticospinal tract (CST) neurons innervate the deep spinal dorsal horn to sustain chronic neuropathic pain. The majority of neurons targeted by the CST are interneurons expressing the transcription factor c-Maf.
Noémie Frezel +12 more
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Endothelial c-Maf prevents MASLD-like liver fibrosis by regulating chromatin accessibility to suppress pathogenic microvascular cell subsets [PDF]
JHEP ReportsBackground & Aims: Liver sinusoidal endothelial cells (LSECs) are highly specialized components of the hepatic vascular niche, regulating liver function and disease pathogenesis through angiocrine signaling.
Manuel Winkler +19 more
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Specification of fetal liver endothelial progenitors to functional zonated adult sinusoids requires c-Maf induction [PDF]
Cell Stem Cell, 2022 Summary Liver vascular network is patterned by sinusoidal and hepatocyte co-zonation. How intra-liver vessels acquire their hierarchical specialized functions is unknown.
Giorgio Inghirami +2 more
exaly +3 more sources
B cell c-Maf signaling promotes tumor progression in animal models of pancreatic cancer and melanoma [PDF]
Journal for ImmunoTherapy of CancerBackground The role of B cells in antitumor immunity remains controversial, with studies suggesting the protumor and antitumor activity. This controversy may be due to the heterogeneity in B cell populations, as the balance among the subtypes may impact ...
Hong Li +8 more
doaj +3 more sources
c-MAF, a Swiss Army Knife for Tolerance in Lymphocytes [PDF]
Frontiers in Immunology, 2020 Beyond its well-admitted role in development and organogenesis, it is now clear that the transcription factor c-Maf has owned its place in the realm of immune-related transcription factors.
Claire Imbratta +3 more
doaj +3 more sources
Inhibition of the Otub1/c-Maf axis by the herbal acevaltrate induces myeloma cell apoptosis [PDF]
Cell Communication and Signaling, 2021 Background The oncogenic transcript factor c-Maf is stabilized by the deubiquitinase Otub1 and promotes myeloma cell proliferation and confers to chemoresistance.
Tong Sun +7 more
doaj +3 more sources
c-Maf restrains T-bet-driven programming of CCR6-negative group 3 innate lymphoid cells [PDF]
eLife, 2020 RORγt+ group 3 innate lymphoid cells (ILC3s) maintain intestinal homeostasis through secretion of type 3 cytokines such as interleukin (IL)−17 and IL-22.
Caroline Tizian +9 more
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The Enigmatic Emerging Role of the C-Maf Inducing Protein in Cancer [PDF]
Diagnostics, 2021 The C-Maf-Inducing protein (CMIP) was first described as overexpressed in T cell subpopulations of idiopathic nephrotic syndrome (INS) patients. Later, it was found concomitantly upregulated in podocytes. CMIP expression has also been reported in several
Mario Ollero, Dil Sahali
doaj +3 more sources
Germinal Center T follicular helper (GC-Tfh) cell impairment in chronic HIV infection involves c-Maf signaling. [PDF]
PLoS Pathogens, 2021 We have recently demonstrated that the function of T follicular helper (Tfh) cells from lymph nodes (LN) of HIV-infected individuals is impaired. We found that these cells were unable to provide proper help to germinal center (GC)-B cells, as observed by
Marita Chakhtoura +10 more
doaj +3 more sources