Results 41 to 50 of about 20,395,316 (257)

c-Maf: a bad influence in the education of macrophages. [PDF]

J Clin Invest, 2020
Tumor-associated macrophages (TAMs) represent the most abundant hematopoietic cell type in the solid tumor microenvironment. TAMs drive T cell inhibition, promote angiogenesis, and produce tumor growth factors. Although they can paradoxically exert antitumor activity and prime protective immunity, the pathways driving this phenotype remain unclear.
Conejo-Garcia JR, Rodriguez PC.
europepmc   +4 more sources

c-MAF deletion in adult C57BL/6J mice induces cataract formation and abnormal differentiation of lens fiber cells [PDF]

Experimental Animals, 2020
Ahmed M Abdellatif, FUJINO Mitsunori, Akihiro Kuno   +2 more
exaly   +2 more sources

Role of c-Maf in Chondrocyte Differentiation [PDF]

CARTILAGE, 2010
Chondrocyte differentiation in the growth plate is an important process for the longitudinal growth of endochondral bones. Sox9 and Runx2 are the most often-studied transcriptional regulators of the chondrocyte differentiation process, but the importance of additional factors is also becoming apparent.
Hong, Eunmee, Di Cesare, Paul E., Haudenschild, Dominik R.   +2 more
openaire   +2 more sources

Tumor-suppressive role of the musculoaponeurotic fibrosarcoma gene in colorectal cancer

iScience, 2023
Summary: Somatic cell reprogramming using the microRNAs miR-200c, miR-302s, and miR-369s leads to increased expression of cyclin-dependent kinase inhibitors in human colorectal cancer (CRC) cells and suppressed tumor growth. Here, we investigated whether
Hiroaki Itakura, Tsuyoshi Hata, Daisuke Okuzaki, Koki Takeda, Kenji Iso, Yamin Qian, Yoshihiro Morimoto, Tomohiro Adachi, Haruka Hirose, Yuhki Yokoyama, Takayuki Ogino, Norikatsu Miyoshi, Hidekazu Takahashi, Mamoru Uemura, Tsunekazu Mizushima, Takao Hinoi, Masaki Mori, Yuichiro Doki, Hidetoshi Eguchi, Hirofumi Yamamoto   +19 more
doaj   +1 more source

RORγt+ c-Maf+ Vγ4+ γδ T cells are generated in the adult thymus but do not reach the periphery.

Cell Reports, 2023
T cell receptor (TCR) Vγ4-expressing γδ T cells comprise interferon γ (IFNγ)- and interleukin-17 (IL-17)-producing effector subsets, with a preference for IL-17 effector fate decisions during early ontogeny. The existence of adult-thymus-derived IL-17+ T 
Tao Yang, Joana Barros-Martins, Zi-Qing Wang, Mélanie Wencker, Jiang Zhang, Justine Smout, Prerna Gambhir, A. Janssen, Anja Schimrock, H. Georgiev, X. León-Lara, S. Weiss, J. Huehn, I. Prinz, Andreas Krueger, R. Foerster, T. Walzer, S. Ravens   +17 more
semanticscholar   +1 more source

Transcription factor c‐Maf drives macrophages to promote hypertrophic scar formation

Journal of Cosmetic Dermatology, 2023
Hypertrophic scar (HS) is caused by the abnormal proliferation of fibroblasts and excessive deposition of extracellular matrix (ECM). Emerging evidence demonstrates that c‐Maf positive M2 macrophages were mainly located in the hypertrophic scar tissues ...
Liu Yang, Yajuan Song, Tong Wang, Zhiwei Cui, Junzheng Wu, Yi Shi, Zhou Yu, Baoqiang Song   +7 more
semanticscholar   +1 more source

Discovery of small molecule c‐Maf inhibitors using molecular docking‐based virtual screening, molecular dynamics simulation, and biological evaluation

Chemical Biology and Drug Design, 2023
Multiple myeloma (MM) is a prevalent plasma cell malignancy in the blood system that remains incurable. Given the abnormally high expression of c‐Maf in most MM patients, targeting c‐Maf presents an attractive therapeutic approach for treating MM ...
Zhi-Wei Hu, Yindi Zeng, Ya-Xin Zhang, Qiu-Rong Zhang, Jin-Ge Xu, Lin-Lin Liu   +5 more
semanticscholar   +1 more source

c-MAF dependent perivascular macrophages regulate diet induced metabolic syndrome

bioRxiv, 2021
Macrophages are an essential part of tissue development and physiology. Perivascular macrophages have been described in tissues and appear to play a role in development and disease processes, although it remains unclear what are the key features of these
Hernandez Moura Silva, Jamil Zola Kitoko, Camila Pereira Queiroz, Lina Kroehling, Fanny Matheis, K. Yang, B. Reis, C. Ren-Fielding, D. Littman, M. Bozza, D. Mucida, J. Lafaille   +11 more
semanticscholar   +1 more source

Differentiation of IL-17-Producing Invariant Natural Killer T Cells Requires Expression of the Transcription Factor c-Maf

Frontiers in Immunology, 2017
c-Maf belongs to the large Maf family of transcription factors and plays a key role in the regulation of cytokine production and differentiation of TH2, TH17, TFH, and Tr1 cells.
Jhang-Sian Yu, Michito Hamada, Shigeo Ohtsuka, Keigyou Yoh, Satoru Takahashi, Shi-Chuen Miaw   +5 more
doaj   +1 more source

The ubiquitin-conjugating enzyme UBE2O modulates c-Maf stability and induces myeloma cell apoptosis

Journal of Hematology & Oncology, 2017
Background UBE2O is proposed as a ubiquitin-conjugating enzyme, but its function was largely unknown. Methods Mass spectrometry was applied to identify c-Maf ubiquitination-associated proteins.
Yujia Xu, Zubin Zhang, Jie Li, Jiefei Tong, Biyin Cao, Paul Taylor, Xiaowen Tang, Depei Wu, Michael F. Moran, Yuanying Zeng, Xinliang Mao   +10 more
doaj   +1 more source