Transcription Factor c-Maf Promotes Immunoregulation of Programmed Cell Death 1-Expressed CD8+ T Cells in Multiple Sclerosis. [PDF]
Neurol Neuroimmunol Neuroinflamm, 2022 Background and Objectives Multiple sclerosis (MS) is an inflammatory demyelinating disease of the CNS. CD8+ T cells are prominently found at inflammatory sites.
Koto S +7 more
europepmc +2 more sources
Cell Reports, 2019 Summary: Mafb and c-Maf transcription factor (TF) expression is enriched in medial ganglionic eminence (MGE) lineages, beginning in late-secondary progenitors and continuing into mature parvalbumin (PV+) and somatostatin (SST+) interneurons. However, the
Emily Ling-Lin Pai +13 more
doaj +2 more sources
Association between C-Maf-inducing protein gene rs2287112 polymorphism and schizophrenia [PDF]
PeerJ, 2021 Background Schizophrenia is a severely multifactorial neuropsychiatric disorder, and the majority of cases are due to genetic variations. In this study, we evaluated the genetic association between the C-Maf-inducing protein (CMIP) gene and schizophrenia
Yingli Fu +6 more
doaj +3 more sources
c-MAF-dependent regulatory T cells mediate immunological tolerance to a gut pathobiont. [PDF]
Nature, 2018 Both microbial and host genetic factors contribute to the pathogenesis of autoimmune diseases. There is accumulating evidence that microbial species that potentiate chronic inflammation, as in inflammatory bowel disease, often also colonize healthy ...
Xu M +9 more
europepmc +2 more sources
c-Maf regulates the plasticity of group 3 innate lymphoid cells by restraining the type 1 program. [PDF]
J Exp Med, 2020 The transcription factor c-Maf is an essential regulator of group 3 ILC homeostasis and effector plasticity. c-Maf limits acquisition of the type 1 program and conversion to the ILC1 fate through restraint of T-bet expression and function.
Parker ME +7 more
europepmc +2 more sources
c-Maf: The magic wand that turns on LSEC fate.
Cell Stem Cell, 2022 In this issue of Cell Stem Cell, Gómez-Salinero et al. (2022) identify c-Maf as a driver for murine liver sinusoidal endothelial cell (LSEC) fate and function during liver development, homeostasis, and repair.
Anna R. Smith, V. Gouon-Evans
semanticscholar +3 more sources
Transcription factor c-Maf-targeted cancer immunotherapy.
Trends in Cancer, 2022 In innate immune cells, the transcription factor cellular musculoaponeurotic fibrosarcoma (c-Maf) influences cell fate and function through molecular and metabolic programming, thereby influencing immune homeostasis and antitumor immunity.
Yun-Ke Wang, F. Qiu, Jun Yan
semanticscholar +3 more sources
The Transcription Factor c-Maf Promotes the Differentiation of Follicular Helper T Cells
Frontiers in Immunology, 2017 Follicular helper T cells (Tfh) have been identified as the primary cell subpopulation regulating B cell responses in germinal centers, thus supporting high-affinity antibody production.
Fabienne Andris +5 more
doaj +2 more sources
The transcription factor c-Maf is essential for the commitment of IL-17-producing γδ T cells. [PDF]
Nat Immunol, 2019 γδ T cells that produce the cytokine IL-17 (Tγδ17 cells) are innate-like mediators of immunity that undergo effector programming in the thymus. While regulators of Tγδ17 specialization restricted to various Vγ subsets are known, a commitment factor ...
Zuberbuehler MK +6 more
europepmc +2 more sources
An immunoregulatory and tissue-residency program modulated by c-MAF in human TH17 cells. [PDF]
Nat Immunol, 2018 Different types of effector and memory T lymphocytes are induced and maintained in protective or pathological immune responses. Here we characterized two human CD4+ TH17 helper cell subsets that, in the recently activated state, could be distinguished on
Aschenbrenner D +8 more
europepmc +2 more sources