Endothelial c-Maf prevents MASLD-like liver fibrosis by regulating chromatin accessibility to suppress pathogenic microvascular cell subsets [PDF]
JHEP ReportsBackground & Aims: Liver sinusoidal endothelial cells (LSECs) are highly specialized components of the hepatic vascular niche, regulating liver function and disease pathogenesis through angiocrine signaling.
Manuel Winkler +19 more
doaj +2 more sources
Association between C-Maf-inducing protein gene rs2287112 polymorphism and schizophrenia [PDF]
PeerJ, 2021 Background Schizophrenia is a severely multifactorial neuropsychiatric disorder, and the majority of cases are due to genetic variations. In this study, we evaluated the genetic association between the C-Maf-inducing protein (CMIP) gene and schizophrenia
Yingli Fu +6 more
doaj +3 more sources
Mafb and c-Maf Have Prenatal Compensatory and Postnatal Antagonistic Roles in Cortical Interneuron Fate and Function [PDF]
Cell Reports, 2019 Summary: Mafb and c-Maf transcription factor (TF) expression is enriched in medial ganglionic eminence (MGE) lineages, beginning in late-secondary progenitors and continuing into mature parvalbumin (PV+) and somatostatin (SST+) interneurons. However, the
Emily Ling-Lin Pai +13 more
doaj +2 more sources
c-Maf restrains T-bet-driven programming of CCR6-negative group 3 innate lymphoid cells [PDF]
eLife, 2020 RORγt+ group 3 innate lymphoid cells (ILC3s) maintain intestinal homeostasis through secretion of type 3 cytokines such as interleukin (IL)−17 and IL-22.
Caroline Tizian +9 more
doaj +2 more sources
SUMOylation attenuates c‐Maf‐dependent IL‐4 expression [PDF]
European Journal of Immunology, 2010 AbstractThe function of transcription factors can be critically regulated by SUMOylation. c‐Maf, the cellular counterpart of v‐maf oncogene, is a potent transactivator of the IL‐4 gene in Th2 cells. We found in a yeast two‐hybrid screen that c‐Maf can interact with Ubc9 and PIAS1, two key enzymes of the SUMOylation pathway.
Li-Fang Wang +2 more
exaly +3 more sources
Germinal Center T follicular helper (GC-Tfh) cell impairment in chronic HIV infection involves c-Maf signaling. [PDF]
PLoS Pathogens, 2021 We have recently demonstrated that the function of T follicular helper (Tfh) cells from lymph nodes (LN) of HIV-infected individuals is impaired. We found that these cells were unable to provide proper help to germinal center (GC)-B cells, as observed by
Marita Chakhtoura +10 more
doaj +2 more sources
c-MAF deletion in adult C57BL/6J mice induces cataract formation and abnormal differentiation of lens fiber cells [PDF]
Experimental Animals, 2020 Ahmed Abdellatif +2 more
exaly +2 more sources
Role of c-Maf in Chondrocyte Differentiation [PDF]
CARTILAGE, 2010 Chondrocyte differentiation in the growth plate is an important process for the longitudinal growth of endochondral bones. Sox9 and Runx2 are the most often-studied transcriptional regulators of the chondrocyte differentiation process, but the importance of additional factors is also becoming apparent.
Hong, Eunmee +2 more
openaire +2 more sources
Tumor-suppressive role of the musculoaponeurotic fibrosarcoma gene in colorectal cancer
iScience, 2023 Summary: Somatic cell reprogramming using the microRNAs miR-200c, miR-302s, and miR-369s leads to increased expression of cyclin-dependent kinase inhibitors in human colorectal cancer (CRC) cells and suppressed tumor growth. Here, we investigated whether
Hiroaki Itakura +19 more
doaj +1 more source
Mebendazole elicits potent antimyeloma activity by inhibiting the USP5/c-Maf axis [PDF]
Acta Pharmacologica Sinica, 2019 Xiaoge Wang, Mao Xin-Liang
exaly +2 more sources