Transcription factor c-Maf: a checkpoint that programs autoimmunity [PDF]
Frontiers in ImmunologyThe transcription factor c-Maf, a member of the Maf family characterized by its basic domain and b-Zip DNA-binding motif, is a pivotal regulator of immune cells development and function.
Na Liu +10 more
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Mebendazole elicits potent antimyeloma activity by inhibiting the USP5/c-Maf axis [PDF]
Acta Pharmacologica Sinica, 2019 c-Maf is a critical oncogenic transcription factor that contributes to myelomagenesis. Our previous studies demonstrated that the deubiquitinase USP5 stabilizes c-Maf and promotes myeloma cell proliferation and survival; therefore, the USP5/c-Maf axis ...
Xiao-Ge Wang +2 more
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Intestinal microbiota-specific Th17 cells possess regulatory properties and suppress effector T cells via c-MAF and IL-10. [PDF]
Immunity, 2023 Summary Commensal microbes induce cytokine-producing effector tissue-resident CD4 T cells, but the function of these T cells in mucosal homeostasis is not well understood.
Brockmann L +6 more
europepmc +2 more sources
A bifurcated role for c-Maf in Th2 and Tfh2 cells during helminth infection. [PDF]
Mucosal Immunol, 2023 Differences in transcriptomes, transcription factor usage, and function have identified T follicular helper 2 (Tfh2) cells and T helper 2 (Th2) cells as distinct clusters of differentiation 4+”,(CD4) T-cell subsets in settings of type-2 inflammation ...
Bao K +8 more
europepmc +2 more sources
Bruceine B Displays Potent Antimyeloma Activity by Inducing the Degradation of the Transcription Factor c-Maf. [PDF]
ACS Pharmacol Transl Sci, 2023 The oncogenic transcription factor c-Maf has been proposed as an ideal therapeutic target for multiple myeloma (MM), a not-yet-curable malignancy of plasma cells.
Li H +7 more
europepmc +2 more sources
The IL-21-TET2-AIM2-c-MAF pathway drives the T follicular helper cell response in lupus-like disease. [PDF]
Clin Transl Med, 2022 Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that involves T follicular helper (TFH) cell‐mediated humoral immune responses. Absent in melanoma 2 (human AIM2 and murine Aim2) is a well‐known component of the inflammasome in the ...
Wu H +17 more
europepmc +2 more sources
c-MAF coordinates enterocyte zonation and nutrient uptake transcriptional programs. [PDF]
J Exp Med, 2022 c-MAF, highly expressed in villus small intestinal enterocytes, coordinates transcriptional programs for nutrient absorption. Enterocyte-specific c-MAF inactivation impairs dietary lipid handling but also leads to tuft cell expansion and adaptive gut ...
González-Loyola A +12 more
europepmc +2 more sources
REV-ERB regulates RORγt+ regulatory T cell specification and function through the Bhlhe40-c-Maf axis. [PDF]
J Exp MedFoxp3+ regulatory T (Treg) cells co-expressing RORγt adopt specialized functions to restrain intestinal inflammation. However, despite extensive characterization, the factors governing RORγt+Foxp3+ Treg specialization remain unclear. Here, we report that
Hu X +11 more
europepmc +2 more sources
Intestinal epithelial c-Maf expression determines enterocyte differentiation and nutrient uptake in mice. [PDF]
J Exp Med, 2022 This study identifies c-Maf as an enterocyte-specific transcription factor within the small intestinal epithelium. c-Maf governs the spatial and functional specialization of enterocytes, especially gene programs controlling intestinal nutrient absorption.
Cosovanu C +9 more
europepmc +2 more sources
c-Maf enforces cytokine production and promotes memory-like responses in mouse and human type 2 innate lymphoid cells. [PDF]
EMBO J, 2022 Group‐2 innate lymphoid cells (ILC2s), which are involved in type 2 inflammatory diseases such as allergy, can exhibit immunological memory, but the basis of this ILC2 "trained immunity" has remained unclear. Here, we found that stimulation with IL‐33/IL‐
Trabanelli S +12 more
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