Results 21 to 30 of about 20,395,316 (257)

Absence of c-Maf and IL-10 enables type I IFN enhancement of innate responses to LPS in alveolar macrophages. [PDF]

J Immunol
Alveolar macrophages (AMs) are lung-resident myeloid cells and airway sentinels for inhaled pathogens and environmental particles. While AMs can be highly inflammatory in response to respiratory viruses, they do not mount pro-inflammatory responses to ...
Lim PN, Cervantes MM, Pham LK, Doherty SR, Tufts A, Dubey D, Mai D, Aderem A, Diercks AH, Rothchild AC.   +9 more
europepmc   +2 more sources

Differential metabolic requirement governed by transcription factor c-Maf dictates innate γδT17 effector functionality in mice and humans. [PDF]

Sci Adv, 2022
Cellular metabolism has been proposed to govern distinct γδ T cell effector functions, but the underlying molecular mechanisms remain unclear. We show that interleukin-17 (IL-17)–producing γδ T (γδT17) and interferon-γ (IFN-γ)–producing γδ T (γδT1) cells
Chen X, Cai Y, Hu X, Ding C, He L, Zhang X, Chen F, Yan J.   +7 more
europepmc   +2 more sources

Blimp-1 and c-Maf regulate  <i>Il10 and </i>negatively regulate common and unique proinflammatory gene networks in IL-12 plus IL-27-driven T helper-1 cells. [PDF]

Wellcome Open Res, 2023
Background CD4 + Th1 cells producing IFN-γ are required to eradicate intracellular pathogens, however if uncontrolled these cells can cause immunopathology.
Cox LS, Alvarez-Martinez M, Wu X, Gabryšová L, Luisier R, Briscoe J, Luscombe NM, O'Garra A.   +7 more
europepmc   +2 more sources

Blimp-1 and c-Maf regulate immune gene networks to protect against distinct pathways of pathobiont-induced colitis. [PDF]

Nat Immunol
Intestinal immune responses to microbes are controlled by the cytokine IL-10 to avoid immune pathology. Here, we use single-cell RNA sequencing of colon lamina propria leukocytes (LPLs) along with RNA-seq and ATAC-seq of purified CD4+ T cells to show ...
Alvarez-Martinez M, Cox LS, Pearson CF, Branchett WJ, Chakravarty P, Wu X, Slawinski H, Al-Dibouni A, Samelis VA, Gabryšová L, Priestnall SL, Suárez-Bonnet A, Mikolajczak A, Briscoe J, Powrie F, O'Garra A.   +15 more
europepmc   +2 more sources

Molecular Mechanisms Driving IL-10- Producing B Cells Functions: STAT3 and c-MAF as Underestimated Central Key Regulators? [PDF]

Front Immunol, 2022
Regulatory B cells (Bregs) have been highlighted in very different pathology settings including autoimmune diseases, allergy, graft rejection, and cancer.
Michée-Cospolite M, Boudigou M, Grasseau A, Simon Q, Mignen O, Pers JO, Cornec D, Le Pottier L, Hillion S.   +8 more
europepmc   +2 more sources

Transcription factor c-Maf is a checkpoint that programs macrophages in lung cancer. [PDF]

J Clin Invest, 2020
Macrophages have been linked to tumor initiation, progression, metastasis and treatment resistance. However, the transcriptional regulation of macrophages driving the pro-tumor function remains elusive.
Liu M, Tong Z, Ding C, Luo F, Wu S, Wu C, Albeituni S, He L, Hu X, Tieri D, Rouchka EC, Hamada M, Takahashi S, Gibb AA, Kloecker G, Zhang HG, Bousamra M, Hill BG, Zhang X, Yan J.   +19 more
europepmc   +2 more sources

Targeting the Liquid–Liquid Separation Region of c‐Maf for Treating Chromosomal Translocations in Multiple Myeloma [PDF]

MedComm
Multiple myeloma (MM), as an incurable hematologic malignancy, is driven by chromosomal translocations. Recent research suggests that targeting phase separation may offer a new therapeutic vulnerability for MM.
Ze Wang, Mengjie Guo, Xichao Yu, Yi Sun, Haowen Bai, Lianxin Zhou, Zihao Liu, Hongming Huang, Chong Wang, Hong Liu, Chunyan Gu, Ye Yang   +11 more
doaj   +2 more sources

A Notch/STAT3-driven Blimp-1/c-Maf-dependent molecular switch induces IL-10 expression in human CD4⁺ T cells and is defective in Crohn´s disease patients. [PDF]

Mucosal Immunol, 2022
Immunosuppressive Interleukin (IL)−10 production by pro-inflammatory CD4+ T cells is a central self-regulatory function to limit aberrant inflammation.
Ahlers J, Mantei A, Lozza L, Stäber M, Heinrich F, Bacher P, Hohnstein T, Menzel L, Yüz SG, Alvarez-Simon D, Bickenbach AR, Weidinger C, Mockel-Tenbrinck N, Kühl AA, Siegmund B, Maul J, Neumann C, Scheffold A.   +17 more
europepmc   +2 more sources

Reciprocal regulation of C-Maf tyrosine phosphorylation by Tec and Ptpn22. [PDF]

PLoS ONE, 2015
C-Maf plays an important role in regulating cytokine production in TH cells. Its transactivation of IL-4 is optimized by phosphorylation at Tyr21, Tyr92, and Tyr131. However, the molecular mechanism regulating its tyrosine phosphorylation remains unknown.
Chih-Chun Liu, Chen-Yen Lai, Wei-Feng Yen, Yu-Hsien Lin, Hui-Hsin Chang, Tzong-Shyuan Tai, Yu-Jung Lu, Hsiao-Wei Tsao, I-Cheng Ho, Shi-Chuen Miaw   +9 more
doaj   +9 more sources

Deletion of Cdk5 in Macrophages Ameliorates Anti-Inflammatory Response during Endotoxemia through Induction of C-Maf and Il-10. [PDF]

Int J Mol Sci, 2021
Immune response control is critical as excessive cytokine production can be detrimental and damage the host. Interleukin-10 (Il-10), an anti-inflammatory cytokine produced primarily by macrophages, is a key regulator that counteracts and controls ...
Pfänder P, Eiers AK, Burret U, Vettorazzi S.   +3 more
europepmc   +2 more sources