Results 21 to 30 of about 4,187 (189)

Pristimerin, a triterpene that inhibits monoacylglycerol lipase activity, prevents the development of paclitaxel-induced allodynia in mice

Frontiers in Pharmacology, 2022
Background: Triterpenes such as euphol and pristimerin, which are plant secondary metabolites, were the first to be characterized as monoacylglycerol lipase (MAGL) inhibitors.
Altaf Al-Romaiyan, Willias Masocha
doaj   +1 more source

Development of a highly-specific 18F-labeled irreversible positron emission tomography tracer for monoacylglycerol lipase mapping

Acta Pharmaceutica Sinica B, 2021
As a serine hydrolase, monoacylglycerol lipase (MAGL) is principally responsible for the metabolism of 2-arachidonoylglycerol (2-AG) in the central nervous system (CNS), leading to the formation of arachidonic acid (AA).
Zhen Chen, Wakana Mori, Jian Rong, Michael A. Schafroth, Tuo Shao, Richard S. Van, Daisuke Ogasawara, Tomoteru Yamasaki, Atsuto Hiraishi, Akiko Hatori, Jiahui Chen, Yiding Zhang, Kuan Hu, Masayuki Fujinaga, Jiyun Sun, Qingzhen Yu, Thomas L. Collier, Yihan Shao, Benjamin F. Cravatt, Lee Josephson, Ming-Rong Zhang, Steven H. Liang   +21 more
doaj   +1 more source

Inhibiting Monoacylglycerol Lipase Suppresses RANKL-Induced Osteoclastogenesis and Alleviates Ovariectomy-Induced Bone Loss

Frontiers in Cell and Developmental Biology, 2021
Osteoporosis is a common chronic metabolic bone disease characterized by reduced trabecular bone and increased bone fragility. Monoacylglycerol lipase (MAGL) is a lipolytic enzyme to catalyze the hydrolysis of monoglycerides and specifically degrades the
Hui Liu, Hui Liu, Chuankun Zhou, Dahu Qi, Yutong Gao, Meipeng Zhu, Tenghui Tao, Xuying Sun, Jun Xiao   +8 more
doaj   +1 more source

Inhibition of MAGL activates the Keap1/Nrf2 pathway to attenuate glucocorticoid‐induced osteonecrosis of the femoral head

Clinical and Translational Medicine, 2021
Glucocorticoids (GCs) are used in treating viral infections, acute spinal cord injury, autoimmune diseases, and shock. Several patients develop GC‐induced osteonecrosis of the femoral head (ONFH).
Ning Yang, Houyi Sun, Yi Xue, Weicheng Zhang, Hongzhi Wang, Huaqiang Tao, Xiaolong Liang, Meng Li, Yaozeng Xu, Liang Chen, Liang Zhang, Lixin Huang, Dechun Geng   +12 more
doaj   +1 more source

Methods for Assessing MAGL Enzymatic Activity: An Extensive Review of Past and Emerging Approaches. [PDF]

Int J Mol Sci
Monoacylglycerol lipase (MAGL) is a key serine hydrolase involved in lipid metabolism, catalyzing the hydrolysis of monoacylglycerols into free fatty acids and glycerol.
Bononi G, Landucci E, Di Stefano M, Piazza L, Bertini S, Macchia M, Granchi C.   +6 more
europepmc   +2 more sources

Targeting Monoacylglycerol Lipase in Pursuit of Therapies for Neurological and Neurodegenerative Diseases

Molecules, 2021
Neurological and neurodegenerative diseases are debilitating conditions, and frequently lack an effective treatment. Monoacylglycerol lipase (MAGL) is a key enzyme involved in the metabolism of 2-AG (2-arachidonoylglycerol), a neuroprotective ...
Anca Zanfirescu, Anca Ungurianu, Dragos Paul Mihai, Denise Radulescu, George Mihai Nitulescu   +4 more
doaj   +1 more source

Quantification of active MAGL (ABPP) and total MAGL protein (WB) in human (Fig 2D) and mouse (Fig 2G) NVU cells.

, 2022
Active MAGL was measured by incubation with the MAGL-specific probe via ABPP. Total MAGL protein expression and β-actin were determined by WB. Average signal intensity of active MAGL and total protein in lysates quantified (A, B) as total detectable ...
Dominik Heer (2169148), Matthias Wittwer (19991), Iris Ruf (13767197), Jörg Benz (13767200), Ludovic Collin (3437399), Benoit Hornsperger (1503058), Bernd Kuhn (260084), Alicia M. Kemble (8555517), Hans Richter (2364346), Britta Engelhardt (307404), Uwe Grether (1594096)   +10 more
core   +1 more source

Monoacylglycerol lipase inhibitors: modulators for lipid metabolism in cancer malignancy, neurological and metabolic disorders

Acta Pharmaceutica Sinica B, 2020
Monoacylglycerol lipase (MAGL) is a serine hydrolase that plays a crucial role catalysing the hydrolysis of monoglycerides into glycerol and fatty acids.
Hui Deng, Weimin Li
doaj   +1 more source

Inhibition of 2-arachidonoylglycerol degradation enhances glial immunity by single-cell transcriptomic analysis

Journal of Neuroinflammation, 2023
Background 2-Arachidonoylglycerol (2-AG) is the most abundant endogenous cannabinoid. Inhibition of 2-AG metabolism by inactivation of monoacylglycerol lipase (MAGL), the primary enzyme that degrades 2-AG in the brain, produces anti-inflammatory and ...
Dexiao Zhu, Jian Zhang, Jack Hashem, Fei Gao, Chu Chen   +4 more
doaj   +1 more source

Gift of the MAGL [PDF]

Science-Business eXchange, 2009
A team at Scripps has developed a compound that should help tease out whether the endocannabinoid-degrading enzyme MAGL is a better pain target than the closely related enzyme FAAH. The answer could enable the design of better cannabinoid receptor agonist–based analgesics.
openaire   +1 more source