Results 61 to 70 of about 79,773 (299)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Improving mechanical properties of AZ31 alloy sheets via novel turned-bearing extrusion by introducing shear strain

Journal of Materials Research and Technology, 2023
In this work, novel turned-bearing extrusions (TBE) conducted by using the dies with the single corner and double corner, named SC-TBE and DC-TBE respectively, are developed to introduce additional shear strain during the preparation of AZ31 alloy sheets,
Lintao Liu, Liping Wei, Jianfei Xiao, Shengwen Bai, Bin Jiang, Chao He, Guangsheng Huang, Dingfei Zhang, Fusheng Pan   +8 more
doaj   +1 more source

Tribocorrosion Properties of PEO Coatings Produced on AZ91 Magnesium Alloy with Silicate- or Phosphate-Based Electrolytes [PDF]

, 2018
In this work, the tribocorrosion behavior of plasma electrolytic oxidation (PEO)-coated AZ91 samples was studied. In particular, two different coatings were produced and compared. One was obtained with an alkaline electrolyte containing sodium phosphate,
Brunelli, Katya, Dabala', Manuele, Gennari, Claudio, Marco, Sinico, Pezzato, Luca, Pietro, Pranovi, Settimi, ALESSIO GIORGIO, Vranescu, Dragos   +7 more
core   +2 more sources

Application of Friction Shear Test for Constitutive Modeling Evaluation of Magnesium Alloy AZ31B at high Temperature [PDF]

, 2020
The experimental determination of the flow stress and its mathematical formulation are essential for the numerical simulation of metal forming processes.
Gensch, Felix, Müller, Sören, Sanabria, Vidal   +2 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Enhancing damping properties of Mg–Sn–Y alloys: The role of metastable clustering

Journal of Materials Research and Technology
The damping properties of Mg–Sn–Y alloys with varied Sn/Y atomic ratios and heat-treatment processes have been studied. In the as-cast state, the alloy with a Sn/Y ratio of 3:1 exhibits the highest damping property in the low strain region due to the low
Xun Chen, Lunchao Zhang, Yuan Yuan, Tao Chen, Jun Wang, Ligang Zhang, Liang Wu, Xianhua Chen, Jingfeng Wang, Fusheng Pan   +9 more
doaj   +1 more source

The influence of position in overlap joints of Mg and Al alloys on microstructure and hardness of laser welds [PDF]

, 2013
Structure and properties of laser beam welding zone of dissimilar materials, AZ31 magnesium alloy and A5754 Aluminum alloy, are investigated. The microstructure and quality of the Mg/Al weld were studied by metallography, microhardness and optical ...
Fatih H., H. Mhiri, J. E. Masse, K. Abderrazak, M. Autric, Nakada K., Peng L., S. Bannour, S. Mattei, Stodolsky R., Yoo M. S.   +10 more
core   +6 more sources

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Localized approach to galvanic coupling in an aluminum–magnesium system [PDF]

, 2009
The corrosion behavior of a pure aluminum/pure magnesium couple in a weakly conductive sodium sulfate solution was investigated. Potential and current distributions on the surface of the model couple at the beginning of immersion were obtained by solving
Blanc, Christine, Lacroix, Loïc, Pébère, Nadine, Tribollet, Bernard, Vivier, Vincent   +4 more
core   +2 more sources

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source