Results 111 to 120 of about 211,167 (339)
Advanced Science, EarlyView.Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang +11 more
wiley +1 more source
Error field predictability and consequences for ITER
Nuclear FusionITER coil tolerances are re-evaluated using the modern understanding of coupling to least-stable plasma modes and an updated center-line-traced model of ITER’s coil windings. This reassessment finds the tolerances to be conservative through a statistical,
M. Pharr +4 more
doaj +1 more source
Advanced Science, EarlyView.HNRNPD promotes radioresistance in nasopharyngeal carcinoma by enhancing stress granule assembly and sequestering GRAMD4 mRNA. This suppresses GRAMD4 translation and inhibits mitochondrial apoptosis. Targeting the integrated stress response with ISRIB restores GRAMD4 expression and sensitizes tumors to radiotherapy, revealing a translational control ...
Yingzi Li +13 more
wiley +1 more source
Turbulence spreading induced vortex flow generation in a magnetic island
Nuclear FusionWe derive a self-consistent relation between turbulence spreading flux and vortex flow acceleration for time-stationary turbulence inside a magnetic island (MI) by extending the Charney-Drazin momentum theorem.
E.S. Yoon +6 more
doaj +1 more source
Magnetic Bays at Macquarie Island [PDF]
Australian Journal of Physics, 1960 Polar magnetic bays are the most striking feature of magnetic records obtained by the Australian National Antarctic Research Expeditions at Macquarie Island. Negative bays are more numerous than positive bays and have greater amplitudes and durations.
openaire +1 more source
Advanced Science, EarlyView.ABSTRACT The E3 ubiquitin ligase tripartite motif 27 (TRIM27) is a negative regulator of NF‐κB activation and the innate immune response, and TRIM27 deficiency significantly impairs dextran sulfate sodium (DSS)‐induced colitis. The function of TRIM27 in intestinal epithelial cells (IECs), the mechanism by which TRIM27 inhibits the NF‐κB pathway and its
Weimin Xu +10 more
wiley +1 more source
, 2001 The nonequilibrium magnetic domain structure of growing ultrathin ferromagnetic films with a realistic atomic structure is studied as a function of coverage and temperature.
Allenspach +41 more
core +1 more source
Advanced Science, EarlyView.Plastin‐2 (PLS2) is identified as a dual‐function receptor on DCs that mediates both nanoparticle uptake and immunomodulation. A nanobody‐LNP platform is engineered to integrate antigen delivery with relicensing DCs. The therapeutic strategy elicits potent anti‐tumor T cell responses and leads to significant inhibition of established tumors in vivo ...
Shugang Qin +9 more
wiley +1 more source
Method for finding the critical temperature of the island in a SET structure
, 2008 We present a method to measure the critical temperature of the island of a superconducting single electron transistor. The method is based on a sharp change in the slope of the zero-bias conductance as a function of temperature.
A P Halvari +7 more
core +1 more source