Results 41 to 50 of about 96,711 (304)

A magnetic bead-integrated chip for the large scale manufacture of normalized esiRNAs. [PDF]

PLoS ONE, 2012
The chemically-synthesized siRNA duplex has become a powerful and widely used tool for RNAi loss-of-function studies, but suffers from a high off-target effect problem.
Zhao Wang, Huang Huang, Hanshuo Zhang, Changhong Sun, Yang Hao, Junyu Yang, Yu Fan, Jianzhong Jeff Xi   +7 more
doaj   +1 more source

Optogenetics and deep brain stimulation neurotechnologies [PDF]

, 2015
Brain neural network is composed of densely packed, intricately wired neurons whose activity patterns ultimately give rise to every behavior, thought, or emotion that we experience. Over the past decade, a novel neurotechnique, optogenetics that combines
A Berndt, A Berndt, A Priori, AA Kuhn, AA Kuhn, AS Chuong, B Sauer, B Wingeier, BY Chow, BY Chow, C Bamann, D Luo, D Oesterhelt, D Oesterhelt, D Williams, ES Boyden, EY Uc, F Zhang, F Zhang, G Foffani, G Miesenbock, G Nagel, J Cavanaugh, J Mobley, J Volkmann, J Wells, J Wietek, JG Bernstein, JG Bernstein, JG Bernstein, JL Spudich, JL Spudich, JO Dostrovsky, JZ Tsien, L Bekar, L Madisen, LA Gunaydin, M Weinberger, M Weinberger, MC Rodriguez-Oroz, MJ Lehmkuhle, ML Welter, MM Doroudchi, O Yizhar, P Brown, P Silberstein, R Levy, R Levy, R Levy, R Waehler, S Zhao, TW Chen, VC Anderson, X Han, X Han, X Han, X Han, X Han, X Liu   +58 more
core   +2 more sources

Co-delivery of doxorubicin and SATB1 shRNA by thermosensitive magnetic cationic liposomes for gastric cancer therapy.

PLoS ONE, 2014
In previous a study, we had developed a novel thermosensitive magnetic delivery system based on liposomes. This study aimed to evaluate the efficiency of this system for the co-delivery of both drugs and genes to the same cell and its anti-tumor effects ...
Zhao Peng, Chenxiao Wang, Erhu Fang, Xiaoming Lu, Guobin Wang, Qiang Tong   +5 more
doaj   +1 more source

Ultrasound assisted siRNA delivery using PEG-siPlex loaded microbubbles [PDF]

, 2008
Short interfering RNA (siRNA) attracts much attention for the treatment of various diseases. However, its delivery, especially via systemic routes, remains a challenge. Indeed, naked siRNAs are rapidly degraded, while complexed siRNAs massively aggregate
De Smedt, Stefaan, Demeester, Jo, Lentacker, Ine, Sanders, Niek, Vandenbroucke, Roosmarijn   +4 more
core   +1 more source

FAS-based cell depletion facilitates the selective isolation of mouse induced pluripotent stem cells. [PDF]

PLoS ONE, 2014
Cellular reprogramming of somatic cells into induced pluripotent stem cells (iPSC) opens up new avenues for basic research and regenerative medicine. However, the low efficiency of the procedure remains a major limitation.
Eva Warlich, Axel Schambach, Dominik Lock, Dirk Wedekind, Silke Glage, Dominik Eckardt, Andreas Bosio, Sebastian Knöbel   +7 more
doaj   +1 more source

Insights into the kinetics of siRNA-mediated gene silencing from live-cell and live-animal bioluminescent imaging [PDF]

, 2006
Small interfering RNA (siRNA) molecules are potent effectors of post-transcriptional gene silencing. Using noninvasive bioluminescent imaging and a mathematical model of siRNA delivery and function, the effects of target-specific and treatment-specific ...
Bartlett, Derek W., Davis, Mark E.
core   +1 more source

Method for reduction of magnetic field of uncertain extended technical objects based on their multyspheroidal model and compensating magnetic dipoles

Electrical engineering & Electromechanics
Problem. The implementation of strict requirements for magnetic silence of elongated energy-saturated objects such as naval vessel and submarines is an important scientific and technical problem of magnetism of technical objects. Purpose.
B. I. Kuznetsov, T. B. Nikitina, I. V. Bovdui, K. V. Chunikhin, V. V. Kolomiets, B. B. Kobylianskyi   +5 more
doaj   +1 more source

GPER agonist G-1 decreases adrenocortical carcinoma (ACC) cell growth in vitro and in vivo [PDF]

, 2015
We have previously demonstrated that estrogen receptor (ER) alpha (ESR1) increases proliferation of adrenocortical carcinoma (ACC) through both an estrogen-dependent and -independent (induced by IGF-II/IGF1R pathways) manner.
Amendola, Donatella, Avena, Paola, Campana, Carmela, Carpinelli, Giulia, Casaburi, Ivan, Cerquetti, Lidia, Chimento, Adele, De Luca, Arianna, Domanico, Francesco, Fallo, Francesco, Malivindi, Rocco, Martire, Emilia, Pezzi, Vincenzo, Rizza, Pietro, Sirianni, Rosa, Stigliano, Antonio, Zolea, Fabiana   +16 more
core   +2 more sources

Stem Cell Imaging: Tools to Improve Cell Delivery and Viability. [PDF]

, 2016
Stem cell therapy (SCT) has shown very promising preclinical results in a variety of regenerative medicine applications. Nevertheless, the complete utility of this technology remains unrealized. Imaging is a potent tool used in multiple stages of SCT and
Jokerst, Jesse V, Wang, Junxin
core   +3 more sources

High-Frequency Repetitive Magnetic Stimulation Activates Bactericidal Activity of Macrophages via Modulation of p62/Keap1/Nrf2 and p38 MAPK Pathways

Antioxidants, 2023
The effects of repetitive magnetic stimulation (rMS) have predominantly been studied in excitable cells, with limited research in non-excitable cells. This study aimed to investigate the impact of rMS on macrophages, which are crucial cells in the innate
Therese B. Deramaudt, Ahmad Chehaitly, Théo Charrière, Julie Arnaud, Marcel Bonay   +4 more
doaj   +1 more source