Multiplex flow magnetic tweezers reveal rare enzymatic events with single molecule precision [PDF]
Nature Communications, 2020 Single molecule force measurements have shed light on dynamic biological events, but rare events escape notice owing to low throughput of the methods. Here, the authors combine an array of magnetic tweezers with lateral flow to increase throughput 100 ...
Rohit Agarwal, Karl E. Duderstadt
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Magnetic tweezers to capture the fast-folding λ6-85 in slow motion [PDF]
Communications PhysicsForce spectroscopy gives access to the underlying free energy landscape of protein folding. Proteins exhibit folding rates between microseconds and hours.
César Augusto Quintana-Cataño +5 more
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Correlating fluorescence microscopy, optical and magnetic tweezers to study single chiral biopolymers such as DNA [PDF]
Nature CommunicationsBiopolymer topology is critical for determining interactions inside cell environments, exemplified by DNA where its response to mechanical perturbation is as important as biochemical properties to its cellular roles.
Jack W. Shepherd +9 more
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A Horizontal Magnetic Tweezers and Its Use for Studying Single DNA Molecules [PDF]
Micromachines, 2018 We report the development of a magnetic tweezers that can be used to micromanipulate single DNA molecules by applying picoNewton (pN)-scale forces in the horizontal plane. The resulting force–extension data from our experiments show high-resolution
Roberto Fabian +4 more
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Magnetic tweezers for the measurement of twist and torque. [PDF]
J Vis Exp, 2014 Single-molecule techniques make it possible to investigate the behavior of individual biological molecules in solution in real time. These techniques include so-called force spectroscopy approaches such as atomic force microscopy, optical tweezers, flow stretching, and magnetic tweezers.
Lipfert J +4 more
europepmc +5 more sources
Skewed brownian fluctuations in single-molecule magnetic tweezers. [PDF]
PLoS ONE, 2014 Measurements in magnetic tweezers rely upon precise determination of the position of a magnetic microsphere. Fluctuations in the position due to Brownian motion allows calculation of the applied force, enabling deduction of the force-extension response ...
Daniel R Burnham +3 more
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Quadrupole Magnetic Tweezers for Precise Cell Transportation. [PDF]
IEEE Trans Biomed EngThis research introduces a quadrupole magnetic tweezers which can be used for precise cell transportation by actuating magnetic spherical microrobots. The focus of the system is on navigating and manipulating cells within environments characterized by high cellular density. Demonstrating efficacy in moving cells through densely packed cell samples, the
Yang Y, Sokolich M, Mallick S, Das S.
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Development of electromagnetic tweezers for single-molecule energetics of kinesin [PDF]
Biophysics and PhysicobiologyOptical tweezers have enabled single-molecule measurements of kinesin mechanics and energetics but face challenges for in vivo applications due to photothermal effects and refractive-index-dependent force calibration.
Haruyuki Fukuzawa +7 more
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Measurement of the magnetic moment of single Magnetospirillum gryphiswaldense cells by magnetic tweezers [PDF]
Scientific Reports, 2017 Magnetospirillum gryphiswaldense is a helix-shaped magnetotactic bacterium that synthesizes iron-oxide nanocrystals, which allow navigation along the geomagnetic field.
C. Zahn +9 more
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Twisted Magnon as a Magnetic Tweezer [PDF]
Physical Review Letters, 2020 6 pages, 4 figures, to appear in ...
Yuanyuan Jiang +6 more
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