Results 41 to 50 of about 30,016 (261)

Single-molecule kinetic locking allows fluorescence-free quantification of protein/nucleic-acid binding

Communications Biology, 2021
Rieu et al. present a magnetic tweezers based single-molecule manipulation method, called kinetic locking, for direct detection of biomolecular binding without use of fluorescent probes. By measuring dynamical interactions of E.
Martin Rieu, Jessica Valle-Orero, Bertrand Ducos, Jean-François Allemand, Vincent Croquette   +4 more
doaj   +1 more source

Optimal transport of ultracold atoms in the non-adiabatic regime [PDF]

, 2008
We report the transport of ultracold atoms with optical tweezers in the non-adiabatic regime, i.e. on a time scale on the order of the oscillation period.
A. Couvert, D. Guéry-Odelin, G. Reinaudi, Grimm R., Harris F., Hommelhoff P., Jacquinot P., Schmid S., T. Kawalec   +8 more
core   +4 more sources

Extracting physical chemistry from mechanics: a new approach to investigate DNA interactions with drugs and proteins in single molecule experiments

, 2015
In this review we focus on the idea of establishing connections between the mechanical properties of DNAligand complexes and the physical chemistry of DNA-ligand interactions.
Rocha, M. S.
core   +1 more source

Drug Targeting Model of Composite Gold-Tourmaline for Cells Enhancing Applications

Nano Biomedicine and Engineering, 2015
The drug delivery and targeting method of gold tourmaline composite atoms generated by optical tweezers in a micro-optical device system is proposed.
Preecha P. Yupapin, Senee Suwandee
doaj   +1 more source

Transport of Bose-Einstein Condensates with Optical Tweezers

, 2001
We have transported gaseous Bose-Einstein condensates over distances up to 44 cm. This was accomplished by trapping the condensate in the focus of an infrared laser and translating the location of the laser focus with controlled acceleration. Condensates
A. E. Leanhardt, A. Görlitz, A. Görlitz, A. Haase, A. P. Chikkatur, B. Anderson, C. Henkel, D. Cassettari, D. E. Pritchard, H. Ott, J. Denschlag, J. Fortagh, S. Gupta, T. L. Gustavson, W. Ketterle, W. Ketterle   +15 more
core   +1 more source

Nanoscale integration of single cell biologics discovery processes using optofluidic manipulation and monitoring. [PDF]

, 2019
The new and rapid advancement in the complexity of biologics drug discovery has been driven by a deeper understanding of biological systems combined with innovative new therapeutic modalities, paving the way to breakthrough therapies for previously ...
Chen, Ching, Chen, Irwin, Chong, Su, Hamburger, Agi, Jess, Philip, Jorgolli, Marsela, Le, Kim, Lin, Fen-Fen, Miranda, Les P, Mock, Marissa, Munro, Trent, Nevill, Tanner, Stevens, Jennitte, Tagari, Philip, Tan, Christopher, Winters, Aaron, Wu, Ming, Xu, Han   +17 more
core   +1 more source

Magnetic Tweezers Measurement of Single Molecule Torque [PDF]

Nano Letters, 2009
Torsional stress in linear biopolymers such as DNA and chromatin has important consequences for nanoscale biological processes. We have developed a new method to directly measure torque on single molecules. Using a cylindrical magnet, we manipulate a novel probe consisting of a nanorod with a 0.1 microm ferromagnetic segment coupled to a magnetic bead.
Celedon, Alfredo, Nodelman, Ilana M., Wildt, Bridget, Dewan, Rohit, Searson, Peter, Wirtz, Denis, Bowman, Gregory D., Sun, Sean X.   +7 more
openaire   +3 more sources

Magnetic tweezers to capture the fast-folding λ6-85 in slow motion

Communications Physics
Force spectroscopy gives access to the underlying free energy landscape of protein folding. Proteins exhibit folding rates between microseconds and hours.
César Augusto Quintana-Cataño, Ann Mukhortava, Mordjane A. Boukhet, Andreas Hartmann, Karl-Ludwig Schumann, Michael Schlierf   +5 more
doaj   +1 more source

CTP promotes efficient ParB-dependent DNA condensation by facilitating one-dimensional diffusion from parS

eLife, 2021
Faithful segregation of bacterial chromosomes relies on the ParABS partitioning system and the SMC complex. In this work, we used single-molecule techniques to investigate the role of cytidine triphosphate (CTP) binding and hydrolysis in the critical ...
Francisco de Asis Balaguer, Clara Aicart-Ramos, Gemma LM Fisher, Sara de Bragança, Eva M Martin-Cuevas, Cesar L Pastrana, Mark Simon Dillingham, Fernando Moreno-Herrero   +7 more
doaj   +1 more source

Electron spin resonance of nitrogen-vacancy centers in optically trapped nanodiamonds

, 2012
Using an optical tweezers apparatus, we demonstrate three-dimensional control of nanodiamonds in solution with simultaneous readout of ground-state electron-spin resonance (ESR) transitions in an ensemble of diamond nitrogen-vacancy (NV) color centers ...
A. N. Cleland, Abbondanzieri, B. J. Aleman, Balasubramanian, Barth, Block, Bradac, Braun, Brites, Chang, Cuche, D. D. Awschalom, D. J. Christle, Duan, Ericsson, Gruber, Hall, Maletinsky, Maze, McGuinness, Neuman, Schoenfeld, Schrand, Svoboda, V. R. Horowitz, Yu   +25 more
core   +1 more source