Results 51 to 60 of about 1,562,446 (293)

Detection of genetic variation and base modifications at base-pair resolution on both DNA and RNA

Communications Biology, 2021
Wang et al. show how genetic sequence and base modifications can be detected simultaneously on single molecules of both DNA and RNA using magnetic tweezers.
Zhen Wang, Jérôme Maluenda, Laurène Giraut, Thibault Vieille, Andréas Lefevre, David Salthouse, Gaël Radou, Rémi Moulinas, Sandra Astete, Pol D’Avezac, Geoff Smith, Charles André, Jean-François Allemand, David Bensimon, Vincent Croquette, Jimmy Ouellet, Gordon Hamilton   +16 more
doaj   +1 more source

Localized force application reveals mechanically sensitive domains of Piezo1

Nature Communications, 2016
Piezo ion channels transduce mechanical forces into biological signals. Here, the authors use magnetic tweezers to pull specific regions of Piezo1, identifying mechanically sensitive domains that are essential for channel activation and inactivation.
Jason Wu, Raman Goyal, Jörg Grandl
doaj   +1 more source

Clinical and Experimental Substantiation of the Possibility of Using a 25G Tip to a Permanent Magnet to Remove Intraocular Foreign Bodies

Oftalʹmologiâ, 2022
Purpose: to develop, experimentally study and evaluate in the clinic the effectiveness of using a 25G handpiece to a permanent operating magnet for IOFB removal.Materials and methods.
A. A. Mikhin, S. V. Churashov, A. N. Kulikov, D. S. Ilyushchenkov   +3 more
doaj   +1 more source

A benchmark data set for the mechanical properties of double-stranded DNA and RNA under torsional constraint

Data in Brief, 2020
Nucleic acids are central to the storage and transmission of genetic information and play essential roles in many cellular processes. Quantitative understanding and modeling of their functions and properties requires quantitative experimental ...
Willem Vanderlinden, Pauline J. Kolbeck, Franziska Kriegel, Philipp U. Walker, Jan Lipfert   +4 more
doaj   +1 more source

Single-molecule kinetic locking allows fluorescence-free quantification of protein/nucleic-acid binding

Communications Biology, 2021
Rieu et al. present a magnetic tweezers based single-molecule manipulation method, called kinetic locking, for direct detection of biomolecular binding without use of fluorescent probes. By measuring dynamical interactions of E.
Martin Rieu, Jessica Valle-Orero, Bertrand Ducos, Jean-François Allemand, Vincent Croquette   +4 more
doaj   +1 more source

Single-molecule study reveals Hmo1, not Hho1, promotes chromatin assembly in budding yeast

mBio, 2023
Linker histone H1 plays a crucial role in various biological processes, including nucleosome stabilization, high-order chromatin structure organization, gene expression, and epigenetic regulation in eukaryotic cells.
Mengxue Wang, Jinghua Li, Yong Wang, Hang Fu, Haoning Qiu, Yanying Li, Ming Li, Ying Lu, Yu Vincent Fu   +8 more
doaj   +1 more source

Micro Magnetic Tweezers for Nanomanipulation Inside Live Cells [PDF]

, 2005
This study reports the design, realization, and characterization of a multi-pole magnetic tweezers that enables us to maneuver small magnetic probes inside living cells.
de Vries, Anthony H.B., de Vries, A.H.B., van Driel, Roel, Kanger, Johannes S., Krenn, Bea E., van Driel, R., Kanger, J.S., Krenn, G.E., de Vries, A.H.   +8 more
core   +3 more sources

Drug Targeting Model of Composite Gold-Tourmaline for Cells Enhancing Applications

Nano Biomedicine and Engineering, 2015
The drug delivery and targeting method of gold tourmaline composite atoms generated by optical tweezers in a micro-optical device system is proposed.
Preecha P. Yupapin, Senee Suwandee
doaj   +1 more source

Robust membrane protein tweezers reveal the folding speed limit of helical membrane proteins

eLife, 2023
Single-molecule tweezers, such as magnetic tweezers, are powerful tools for probing nm-scale structural changes in single membrane proteins under force.
Seoyoon Kim, Daehyo Lee, WC Bhashini Wijesinghe, Duyoung Min   +3 more
doaj   +1 more source

Micro/Nanoscale Acoustic Manipulation: From Particle Control to Autonomous Microswimmers. [PDF]

Adv Sci (Weinh)
This conceptual framework illustrates acoustic technology as a multifunctional platform enabling passive particle manipulation across scales and autonomous propulsion of microswimmers. ABSTRACT Acoustic manipulation and propulsion technologies have emerged as powerful platforms for micro/nanoscale control, enabled by their non‐contact operation, label ...
Chu J, Zhang L, Wang X, Li W, Liu Y.
europepmc   +2 more sources