Results 71 to 80 of about 1,562,446 (293)

The mechanism of DNA unwinding by the eukaryotic replicative helicase

Nature Communications, 2019
How the eukaryotic helicase unzips DNA during replication is not well understood. By measuring the real-time motion of purified CMG unwinding DNA with magnetic tweezers, the authors reveal the dynamics where isolated CMG unwinds via a biased random walk ...
Daniel R. Burnham, Hazal B. Kose, Rebecca B. Hoyle, Hasan Yardimci   +3 more
doaj   +1 more source

A Geometrically Transient Platform for Bioelectronic Implants

Advanced Materials, EarlyView.
Minimally invasive bioelectronic implants often compromise performance for smaller sizes. To resolve this optimization dilemma, a wireless bioelectronic implant with a transient geometry is introduced (MiFi). The origami‐inspired device miniaturizes up to sixfold for syringe insertion and autonomously unfolds post‐implantation.
Selin Olenik, John D. Goodwin, Atharv Naik, Philip Coatsworth, Ioi Chit Cheung, Farbod Amirghasemi, Anies Sohi, Ehsan Abedi, Tayeb Tadlaoui, Maral P. S. Mousavi, Andriy S. Kozlov, Victoria Salem, Andrew S. Cowburn, Firat Guder   +13 more
wiley   +1 more source

Development of electromagnetic tweezers for single-molecule energetics of kinesin

Biophysics and Physicobiology
Optical tweezers have enabled single-molecule measurements of kinesin mechanics and energetics but face challenges for in vivo applications due to photothermal effects and refractive-index-dependent force calibration.
Haruyuki Fukuzawa, Yuga Ihara, Masato Sawa, Hidekazu Shirai, Sawako Enoki, Keigo Ikezaki, Taketoshi Kambara, Yasushi Okada   +7 more
doaj   +1 more source

Bioinspired Adaptive Surfaces for Intelligent Liquid Manipulation: Progressing From Passive and Active to Hybrid Strategies

Advanced Materials, EarlyView.
This review examines passive, active, and hybrid liquid manipulation strategies, highlighting hybrid approaches as an emerging route to reconcile energy efficiency with adaptive control. By actively reconstructing passive surfaces to store programmable interfacial energy, hybrid systems enable flexible yet low‐power liquid transport, with perspectives ...
Jiaqi Miao, Yiyuan Zhang, Liqiu Wang, Alan C. H. Tsang   +3 more
wiley   +1 more source

Single molecule high-throughput footprinting of small and large DNA ligands

Nature Communications, 2017
Mapping the sequence specificity of DNA ligands remains a challenge, particularly for small drugs. Here the authors develop a parallelized single molecule magnetic tweezers approach using engineered DNA hairpins that can detect sequence selectivity ...
Maria Manosas, Joan Camunas-Soler, Vincent Croquette, Felix Ritort   +3 more
doaj   +1 more source

CTP promotes efficient ParB-dependent DNA condensation by facilitating one-dimensional diffusion from parS

eLife, 2021
Faithful segregation of bacterial chromosomes relies on the ParABS partitioning system and the SMC complex. In this work, we used single-molecule techniques to investigate the role of cytidine triphosphate (CTP) binding and hydrolysis in the critical ...
Francisco de Asis Balaguer, Clara Aicart-Ramos, Gemma LM Fisher, Sara de Bragança, Eva M Martin-Cuevas, Cesar L Pastrana, Mark Simon Dillingham, Fernando Moreno-Herrero   +7 more
doaj   +1 more source

Artificial Intelligence Meets Micro/Nanorobotics

Advanced Materials, EarlyView.
Artificial intelligence is transforming micro‐ and nanorobots from externally controlled, task‐specific machines into adaptive, autonomous systems. Machine learning, multimodal perception, digital twins, AI‐guided materials and geometry design enhance propulsion, localization, decision‐making, whichaccelerates clinical and environmental applications ...
Fatma M. Yurtsever, Minitha Cherukutty Ramakrishnan, Ian Kuula Ross, Ivan Zelinka, Hamed Shahsavan, Michal Otyepka, Martin Pumera   +6 more
wiley   +1 more source

Protein Unfolding: Denaturant vs. Force

Biomedicines, 2021
While protein refolding has been studied for over 50 years since the pioneering work of Christian Anfinsen, there have been a limited number of studies correlating results between chemical, thermal, and mechanical unfolding.
Colleen Kelly, Matthew J. Gage
doaj   +1 more source

Acoustic Devices for Particle and Cell Manipulation and Sensing [PDF]

, 2014
An emerging demand for the precise manipulation of cells and particles for applications in cell biology and analytical chemistry has driven rapid development of ultrasonic manipulation technology.
Hughes, David, Sylvia Gebhardt, Poltarjonoks, Romans, Sandy Cochran, David A. Hughes, Cochran, Sandy, Aleksandrs Bolhovitins, Gebhardt, Sylvia, Han Wang, Romans Poltarjonoks, Martyn Hill, Schönecker, Andreas, Peter Glynne-Jones, Christine Demore, Christine E. M. Demore, Weijer, Kees; id_orcid, Kees Weijer, Hill, Martyn, Hughes, David A., Glynne-Jones, Peter, Demore, Christine E. M., Bolhovitins, Aleksandrs, Yongqiang Qiu, Demore, Christine, David Hughes, Andreas Schönecker, Qiu, Yongqiang, Wang, Han, Weijer, Kees   +28 more
core   +1 more source

Biodegradable and Edible Milli‐Fluidic Logic Circuits

Advanced Materials Technologies, EarlyView.
Fully biodegradable and edible fluidic circuits are developed using gelatin‐based valves that operate at low pressure. Logic gates, a one‐bit memory, and a ring oscillator are demonstrated, showing that biodegradable materials can perform computation and control.
Shuhang Zhang, Bokeon Kwak, Özgün Ekrem, Dario Floreano   +3 more
wiley   +1 more source