Results 61 to 70 of about 30,016 (261)

Rheology at the micro-scale: new tools for bio-analysis [PDF]

open access: yes, 2013
We present a simple and non-invasive experimental procedure to measure the linear viscoelastic properties of cells by passive particle tracking microrheology.
Carlsson, A.   +6 more
core   +1 more source

Dual‐Layer Living Hydrogel Enables On‐Demand Delivery of Phages and Probiotics for Synergistic Wound Infection Therapy

open access: yesAdvanced Functional Materials, EarlyView.
A dual‐layer living hydrogel, ProΦGel, integrates bacteriophages and probiotics for synergistic wound infection therapy. The outer gelatin‐based matrix releases phages on demand in response to P. aeruginosa infections, while inner alginate beads sustain probiotic delivery.
Siyuan Tao   +6 more
wiley   +1 more source

Single-molecule study reveals Hmo1, not Hho1, promotes chromatin assembly in budding yeast

open access: yesmBio, 2023
Linker histone H1 plays a crucial role in various biological processes, including nucleosome stabilization, high-order chromatin structure organization, gene expression, and epigenetic regulation in eukaryotic cells.
Mengxue Wang   +8 more
doaj   +1 more source

Computational toolbox for optical tweezers in geometrical optics

open access: yes, 2014
Optical tweezers have found widespread application in many fields, from physics to biology. Here, we explain in detail how optical forces and torques can be described within the geometrical optics approximation and we show that this approximation ...
Callegari, Agnese   +3 more
core   +1 more source

MagPiezo: A Magnetogenetic Platform for Remote Activation of Endogenous Piezo1 Channels in Endothelial Cells

open access: yesAdvanced Functional Materials, EarlyView.
MagPiezo enables wireless activation of endogenous Piezo1 channels without genetic modification using 19 nm magnetic nanoparticles and low‐intensity magnetic fields. It generates torque forces at the piconewton scale to trigger mechanotransduction in endothelial cells, standing as a novel platform to interrogate and manipulate Piezo1 activity in vitro.
Susel Del Sol‐Fernández   +7 more
wiley   +1 more source

Single molecule high-throughput footprinting of small and large DNA ligands

open access: yesNature Communications, 2017
Mapping the sequence specificity of DNA ligands remains a challenge, particularly for small drugs. Here the authors develop a parallelized single molecule magnetic tweezers approach using engineered DNA hairpins that can detect sequence selectivity ...
Maria Manosas   +3 more
doaj   +1 more source

Robust membrane protein tweezers reveal the folding speed limit of helical membrane proteins

open access: yeseLife, 2023
Single-molecule tweezers, such as magnetic tweezers, are powerful tools for probing nm-scale structural changes in single membrane proteins under force.
Seoyoon Kim   +3 more
doaj   +1 more source

Experimental investigations of the dipolar interactions between single Rydberg atoms

open access: yes, 2016
This review summarizes experimental works performed over the last decade by several groups on the manipulation of a few individual interacting Rydberg atoms. These studies establish arrays of single Rydberg atoms as a promising platform for quantum state
Barredo, Daniel   +2 more
core   +1 more source

Subpiconewton Dynamic Force Spectroscopy Using Magnetic Tweezers [PDF]

open access: yesBiophysical Journal, 2008
We introduce a simple method for dynamic force spectroscopy with magnetic tweezers. This method allows application of subpiconewton force and twist control by calibration of the applied force from the height of the magnets. Initial dynamic force spectroscopy experiments on DNA molecules revealed a large hysteresis that is caused by viscous drag on the ...
Kruithof, M.   +3 more
openaire   +2 more sources

Coagulative Granular Hydrogels with an Enzyme Catalyzed Fibrin Network for Endogenous Tissue Regeneration

open access: yesAdvanced Healthcare Materials, EarlyView.
Coagulative granular hydrogels are composed of packed thrombin‐functionalized microgels that catalyze the conversion of fibrinogen into a secondary fibrin network, filling the interstitial voids. This bio‐inspired approach stabilizes the biomaterial to match the robustness of bulk hydrogels without compromising injectability, mimicking the initial ...
Zhipeng Deng   +16 more
wiley   +1 more source

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