Results 71 to 80 of about 5,297,615 (283)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Magnitude-range brightness variations of overactive K giants
, 2014 We study three representative, overactive spotted K giants (IL Hya, XX Tri, and DM UMa) known to exhibit V-band light variations between 0.65-1.05 mags. Our aim is to find the origin of their large brightness variation. We employ long-term phase-resolved
Granzer, T. +6 more
core +1 more source
The colour magnitude relation for galaxies in the Coma cluster [PDF]
, 2001 We present a new photometric catalogue of the Coma galaxy cluster in the Johnson U- and V- bands. We cover an area of 3360arcmin2 of sky, to a depth of V=20 mag in a 13 arcsec diameter aperture, and produce magnitudes for ~1400 extended objects in metric
A.I. Terlevich +58 more
core +3 more sources
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
The Orbital and Absolute Magnitude Distributions of Main Belt Asteroids [PDF]
, 1998 We have developed a model-independent analytical method for debiasing the four-dimensional (a,e,i,H) distribution obtained in any asteroid observation program and have applied the technique to results obtained with the 0.9m Spacewatch Telescope.
Anders +30 more
core +4 more sources
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Dizhen xuebao, 2018 本文针对2008年5月12日四川汶川MW7.9地震后的余震目录，采用2004年Shcherbakov和Turcotte提出的最大余震震级推断法，给出了最大余震震级的估计值。结果表明，采用现有的余震数据，在大震级区间可能存在一定数量的余震缺失，这造成了余震数据与Gutenberg-Richter定律曲线在大震级区间的差异，导致推断的最大余震震级与使用目录中的最大余震震级存在明显差异。利用震级与断层长度或地表破裂长度之间的经验关系可以看出，由灌县—江油断裂的破裂尺度得到的震级与推断最大余震震级基本一致 ...
Mengyu Xie, Baoping Shi
doaj +1 more source
Earthquake Magnitude and Intensity [PDF]
In this exercise, students compare the amount of shaking caused by historic earthquakes, and use data from seismograms to determine Richter magnitude.
Nicholas Pinter
core
Magnitude control of commutator errors [PDF]
, 2006 Non-uniform filtering of the Navier-Stokes equations expresses itself, next to the turbulent stresses, in additional closure terms known as commutator errors.
Geurts, Bernard J.
core +1 more source
Stable Recovery from the Magnitude of Symmetrized Fourier Measurements
, 2013 In this note we show that stable recovery of complex-valued signals $x\in\mathbb{C}^n$ up to global sign can be achieved from the magnitudes of $4n-1$ Fourier measurements when a certain "symmetrization and zero-padding" is performed before measurement ($
Jung, Peter, Walk, Philipp
core +1 more source