Results 71 to 80 of about 5,309,234 (282)
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Magnitude-range brightness variations of overactive K giants
, 2014 We study three representative, overactive spotted K giants (IL Hya, XX Tri, and DM UMa) known to exhibit V-band light variations between 0.65-1.05 mags. Our aim is to find the origin of their large brightness variation. We employ long-term phase-resolved
Granzer, T. +6 more
core +1 more source
Screening for lung cancer: A systematic review of overdiagnosis and its implications
Molecular Oncology, EarlyView.Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz +12 more
wiley +1 more source
Stable Recovery from the Magnitude of Symmetrized Fourier Measurements
, 2013 In this note we show that stable recovery of complex-valued signals $x\in\mathbb{C}^n$ up to global sign can be achieved from the magnitudes of $4n-1$ Fourier measurements when a certain "symmetrization and zero-padding" is performed before measurement ($
Jung, Peter, Walk, Philipp
core +1 more source
The magnitude of viscous dissipation in strongly stratified two-dimensional convection [PDF]
, 2017 Convection in astrophysical systems must be maintained against dissipation. Although the effects of dissipation are often assumed to be negligible, theory suggests that in strongly stratified convecting fluids, the dissipative heating rate can exceed the
Browning, Matthew K., Currie, Laura K.
core +2 more sources
Molecular Oncology, EarlyView.Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece +18 more
wiley +1 more source
Earthquake Magnitude and Intensity [PDF]
In this exercise, students compare the amount of shaking caused by historic earthquakes, and use data from seismograms to determine Richter magnitude.
Nicholas Pinter
core
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Dizhen xuebao, 2018 本文针对2008年5月12日四川汶川MW7.9地震后的余震目录，采用2004年Shcherbakov和Turcotte提出的最大余震震级推断法，给出了最大余震震级的估计值。结果表明，采用现有的余震数据，在大震级区间可能存在一定数量的余震缺失，这造成了余震数据与Gutenberg-Richter定律曲线在大震级区间的差异，导致推断的最大余震震级与使用目录中的最大余震震级存在明显差异。利用震级与断层长度或地表破裂长度之间的经验关系可以看出，由灌县—江油断裂的破裂尺度得到的震级与推断最大余震震级基本一致 ...
Mengyu Xie, Baoping Shi
doaj +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source