Results 81 to 90 of about 5,309,234 (282)
Sign- and magnitude-tunable coupler for superconducting flux qubits
, 2007 We experimentally confirm the functionality of a coupling element for flux-based superconducting qubits, with a coupling strength $J$ whose sign and magnitude can be tuned {\it in situ}.
A. B. Wilson +20 more
core +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Seismic effect of industrial explosions of GOK Kostomuksha
Vestnik MGTU, 2020 Active development of quarries in the Republic of Karelia contributes to the improvement of the control system of the parameters of drilling and blasting operations with the aim of ensuring the safety of buildings and structures near mining facilities ...
Zueva I. A., Lebedev A. A.
doaj +1 more source
Sublime in Its Magnitude : The Emancipation Proclamation
, 2007 Book Summary: Lincoln’s reelection in 1864 was a pivotal moment in the history of the United States. The Emancipation Proclamation had officially gone into effect on January 1, 1863, and the proposed Thirteenth Amendment had become a campaign issue ...
Guelzo, Allen C.
core
The Absolute Magnitude of RRc Variables From Statistical Parallax
, 2012 We present the first definitive measurement of the absolute magnitude of RR Lyrae c-type variable stars (RRc) determined purely from statistical parallax. We use a sample of 247 RRc selected from the All Sky Automated Survey (ASAS) for which high-quality
Albrecht +45 more
core +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
HIV/AIDS: Research and Palliative Care, 2020 Peter Stephen Shija,1,2 Joshua Alexander Karaba,1,2 Rune Nathaniel Philemon,1,3 Bernard Lucas Minja,1 Philbert Patrick Mtenga,1,2 Denis Robert Katundu1,2 1Kilimanjaro Christian Medical Center Moshi (KCMC), Moshi, Tanzania; 2Department of Ear Nose and ...
Shija PS +5 more
doaj
On the Color Magnitude Relation of Early-type Galaxies
, 2009 In this letter we present a study of the color magnitude relation of 468 early-type galaxies in the Virgo Cluster with Sloan Digital Sky Survey imaging data.
Adelman-McCarthy +29 more
core +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source