Results 81 to 90 of about 166,212 (332)
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source
Maintainence of parasitaemia – is it to die for? [PDF]
Kinetoplastid Biology and Disease, 2003 One of the major differences between protozoan differentiation and metazoan differentiation is that protozoan cells normally retain potency during differentiation, which need not, therefore, be considered altruistic. Altruism does, however, arise at the level of the organism and consequently, protozoons have the potential to evolve altruistic traits ...
openaire +4 more sources
Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation
FEBS Letters, EarlyView.The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen +2 more
wiley +1 more source
Why Modern Open Source Projects Fail
, 2017 Open source is experiencing a renaissance period, due to the appearance of modern platforms and workflows for developing and maintaining public code. As a result, developers are creating open source software at speeds never seen before.
Androutsellis-Theotokis Stephanos +5 more
core +1 more source
ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling
FEBS Letters, EarlyView.In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li +3 more
wiley +1 more source
RAM analysis of earth pressure balance tunnel boring machines: A case study [PDF]
International Journal of Mining and Geo-Engineering, 2015 Earth pressure balance tunnel boring machines (EPB-TBMs) are favorably applied in urban tunneling projects. Despite their numerous advantages, considerable delays and high maintenance cost are the main disadvantages these machines suffer from ...
Hasel Amini Khoshalan +3 more
doaj
Maintaining the unmethylated state [PDF]
Clinical Epigenetics, 2013 A remarkable correspondence exists between the cytogenetic locations of the known fragile sites and frequently reported sites of hypermethylation. The best-known features of fragile sites are sequence motifs that are prone to the spontaneous formation of a non-B DNA structure.
openaire +3 more sources
Architecture for Analysis of Streaming Data
, 2018 While several attempts have been made to construct a scalable and flexible architecture for analysis of streaming data, no general model to tackle this task exists.
Hoque, Sheik, Miranskyy, Andriy
core +1 more source
FEBS Letters, EarlyView.In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker +8 more
wiley +1 more source
Buildings, 2020 Sustainable building practices are rooted in the need for reliable information on the long-term performance of building materials; specifically, the expected service-life of building materials, components, and assemblies.
Michael A. Lacasse +2 more
doaj +1 more source