Results 111 to 120 of about 6,138,855 (383)

Comparing Maintenance Strategies for Overlays [PDF]

, 2007
In this paper, we present an analytical tool for understanding the performance of structured overlay networks under churn based on the master-equation approach of physics. We motivate and derive an equation for the average number of hops taken by lookups
Aurell, Erik, El-Ansary, Sameh, Haridi, Seif, Krishnamurthy, Supriya   +3 more
core   +2 more sources

Active Distribution Network Fault Location Based on Petri Nets and Improved Particle Swarm Optimization Algorithm

Electrica
To address issues such as inadequate fault tolerance, long computation time, and limited universality in fault location for active distribution networks, this paper proposes a fault location method that combines Petri nets with an improved particle swarm
Yunfeng Xia, Jie Yang, Junan Chen, Yeming Lai , Sheng Ye   +4 more
doaj   +1 more source

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

FEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source

Vedolizumab as induction and maintenance therapy for ulcerative colitis.

New England Journal of Medicine, 2013
BACKGROUND Gut-selective blockade of lymphocyte trafficking by vedolizumab may constitute effective treatment for ulcerative colitis. METHODS We conducted two integrated randomized, double-blind, placebo-controlled trials of vedolizumab in patients ...
B. Feagan, P. Rutgeerts, B. Sands, S. Hanauer, J. Colombel, W. Sandborn, G. Van Assche, J. Axler, Hyo-Jong Kim, S. Danese, I. Fox, C. Milch, S. Sankoh, T. Wyant, Jing Xu, A. Parikh   +15 more
semanticscholar   +1 more source

Human GEN1 and the SLX4-Associated Nucleases MUS81 and SLX1 Are Essential for the Resolution of Replication-Induced Holliday Junctions

Cell Reports, 2013
Holliday junctions (HJs), the DNA intermediates of homologous recombination, need to be faithfully processed in order to preserve genome integrity. In human cells, the BLM helicase complex promotes nonnucleolytic dissolution of double HJs.
Elizabeth Garner, Yonghwan Kim, Francis P. Lach, Molly C. Kottemann, Agata Smogorzewska   +4 more
doaj   +1 more source

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Definition of Maintenance and Maintenance Types with Due Care on Preventive Maintenance

, 2023
In this chapter maintenance concept is defined and maintenance types are classified with regard to implementing maintenance policies toward preventive maintenance. Especially achieving planned maintenance policies toward preventive (planned) maintenance and condition based maintenance policies toward predictive maintenance is taken into consideration ...
openaire   +2 more sources

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

FEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang, Frans Bianchi, Geert van den Bogaart   +2 more
wiley   +1 more source

An approach to software maintenance support using a syntactic source code analyser data base : this thesis is presented in a partial fulfillment of the requirements for the degree of Master of Arts in Computer Science at Massey University [PDF]

, 1987
In this thesis, the development of a software maintenance tool called a syntactic source code analyser (SSCA) is summarised. An SSCA supports other maintenance tools which interact with source code by creating a data base of source information which has ...
Parkin, Peter Vivian
core  

Duplex DNA engagement and RPA oppositely regulate the DNA-unwinding rate of CMG helicase

Nature Communications, 2020
During eukaryotic chromosome replication cells utilize ring-shaped CMG helicase that separates the two strands of the DNA double helix. Here the authors reveal that CMG helicase activity is inhibited by duplex DNA engagement at the fork, which is ...
Hazal B. Kose, Sherry Xie, George Cameron, Melania S. Strycharska, Hasan Yardimci   +4 more
doaj   +1 more source