Results 91 to 100 of about 9,537,434 (312)

Pemetrexed in maintenance treatment of advanced non-squamous non-small-cell lung cancer

, 2015
Seigo Minami,1 Takashi Kijima2 1Department of Respiratory Medicine, Osaka Police Hospital, 2Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University Graduate School of Medicine, Osaka, Japan Abstract: Pemetrexed, a ...
Kijima T, Minami S
core  

Developments in continuous therapy and maintenance treatment approaches for patients with newly diagnosed multiple myeloma

, 2020
The evolving paradigm of continuous therapy and maintenance treatment approaches in multiple myeloma (MM) offers prolonged disease control and improved outcomes compared to traditional fixed-duration approaches. Potential benefits of long-term strategies
Huang, Jeffrey S.Y., Rocci, Alberto, Attal, Michel, Ramasamy, Karthik, Palumbo, Antonio, Skacel, Tomas, Anderson, Kenneth C., Orlowski, Robert Z., Chng, Wee Joo, Goldschmidt, Hartmut, Zweegman, Sonja, Holstein, Sarah A., Lu, Jin, Jakubowiak, Andrzej J., Spencer, Andrew, Labotka, Richard, Sunami, Kazutaka, Weisel, Katja C., Iida, Shinsuke, Dimopoulos, Meletios A., McCarthy, Philip L., Bladé, Joan   +21 more
core   +1 more source

Assessing maintenance contracts when preventive maintenance is outsourced [PDF]

, 2012
In some companies, corrective maintenance is conducted in-house but preventive maintenance might be outsourced. This raises a need to optimise some parameters such as the number of contracts from a perspective of the equipment owner.
Shaomin Wu, Wu, Shaomin
core   +1 more source

Haploidentical Hematopoietic Cell Transplantation for Infants With X‐Linked Severe Combined Immunodeficiency Using Post‐Transplant Cyclophosphamide

Pediatric Blood &Cancer, EarlyView.
Shuhei Takahashi, Akito Kawachi, Dan Tomomasa, Eri Watanabe, Yuji Fujita, Yuya Sato, Masahiro Sekiguchi, Kentaro Watanabe, Moe Hidaka, Akihiro Hoshino, Takahiro Kamiya, Masatoshi Takagi, Hirokazu Kanegane, Motohiro Kato   +13 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Intranasal esketamine plus oral antidepressant for treatment-resistant depression: acute induction and maintenance relapse-prevention outcomes in a systematic review and meta-analysis

Frontiers in Psychiatry
Treatment-resistant depression (TRD) remains a major clinical challenge. Intranasal esketamine, used adjunctively with an oral antidepressant, has been evaluated in randomized trials, but uncertainty persists regarding the magnitude and consistency of ...
Jingqiang Xie, Chunying Pu, Mingyue Sun
doaj   +1 more source

Diagnosis and treatment of follicular lymphoma

Swiss Medical Weekly, 2011
Follicular lymphoma is a slow-growing disease exhibiting a heterogeneous clinical course, with a subset of patients experiencing a rapid disease course in the first two years and some developing disease transformation to a more aggressive ...
F Hitz, A Lohri, S Pederiva, K Yeow, S Bodis, E Zucca   +5 more
doaj   +1 more source

Module 8: Accomplishments, Maintenance, and Relapse Prevention

, 2010
Chapter 15 explores the eighth and final module on reviewing the treatment skills, evaluating progress and accomplishments that have been made, maintenance, relapse prevention, anticipating future difficulties, continuing practice, and establishing long ...
Christopher P. Fairholme, Ehrenreich-May, Jill T, Allen, Laura B, Fairholme, Christopher P, Barlow, David H, Jill T. Ehrenreich-May, Farchione, Todd J, David H. Barlow, Laura B. Allen, Boisseau, Christina L, Kristen K. Ellard, Ellard, Kristen K, Todd J. Farchione, Christina L. Boisseau   +13 more
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Rucaparib: a novel PARP inhibitor for BRCA advanced ovarian cancer

Drug Design, Development and Therapy, 2018
Ilaria Colombo, Stephanie Lheureux, Amit Manulal Oza Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada Abstract: Rucaparib is a potent small-molecule inhibitor of poly (ADP ...
Colombo I, Lheureux S, Oza AM
doaj