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An overview on the identification of MAIT cell antigens [PDF]

Immunology and Cell Biology, 2018
Mucosal Associated Invariant T (MAIT) cells are restricted by the monomorphic MHC class I-like molecule, MHC-related protein-1 (MR1). Until 2012, the origin of the MAIT cell antigens (Ags) was unknown, although it was established that MAIT cells could be
Lars Kjer-Nielsen, Alexandra J Corbett, Zhenjun Chen   +2 more
exaly   +8 more sources

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MAIT Cells in Health and Disease

Annual Review of Immunology, 2020
Mucosal-associated invariant T (MAIT) cells have been attracting increasing attention over the last few years as a potent unconventional T cell subset. Three factors largely account for this emerging interest. Firstly, these cells are abundant in humans, both in circulation and especially in some tissues such as the liver.
Nicholas M Provine, Paul Klenerman
exaly   +3 more sources

Role of MAIT cells in metabolic diseases

Molecular Immunology, 2021
MAIT cells are innate-like T cells that are enriched in mucosal sites and tissues including adipose tissue and liver. They play an important role in immunity against microbial pathogens. Recently, it has been reported that MAIT cells could also be important in metabolic diseases and can be involved in setting up and maintaining chronic inflammation. In
Amine, Toubal, Agnès, Lehuen
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MAIT cells in infectious diseases

Current Opinion in Immunology, 2017
In humans, MAIT cells represent the most abundant T cell subset reacting against bacteria. Their frequency in the blood is decreased in a large variety of infectious diseases of either bacterial or viral origin. MAIT cells accumulate at the site of bacterial infection and are protective in experimental infection models.
Marion, Salou, Katarzyna, Franciszkiewicz, Olivier, Lantz   +2 more
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MAIT cell development in mice and humans

Molecular Immunology, 2021
MAIT cells arise in the thymus following rearrangement of a T cell receptor (TCR) reactive against microbial vitamin B2-derived metabolites presented by the MHC-Ib molecule, MR1. Mechanisms that are conserved in mammals ensure the frequent production of MR1-restricted TCRs and the intra-thymic differentiation of MR1-restricted thymocytes into effector ...
Marion, Salou, François, Legoux, Olivier, Lantz   +2 more
openaire   +2 more sources

Macrophage MR1 antigen presentation promotes MAIT cell immunity and lung microbiota modulation.

Science
Mucosal associated invariant T (MAIT) cells mediate tissue homeostasis and antimicrobial immunity. However, the cells that express MHC class I-related protein 1 (MR1) and present microbial vitamin B-derived antigens (VitBAg) to MAIT cells remain unknown.
Jieru Deng, Yuting Yan, Xiaoyue Zhang, Calum J. Walsh, Emmanuel Montassier, Debajyoti Sinha, Huimeng Wang, A. Mousavizadeh, Mitra Ashayeripanah, Jeffrey Y. W. Mak, H. Koay, Tobias Poch, Yannick O. Alexandre, Scott N. Mueller, Ajithkumar Vasanthakumar, Tim P Stinear, Vanta J Jameson, Alexis Perez-Gonzalez, Jenny Kingham, T. G. Phan, Nikita Potemkin, Lachlan Dryburgh, Jan Schroeder, David P. Fairlie, Laura K. Mackay, Zhenjun Chen, Laura Cook, Abderrahman Hachani, A. Corbett, A. Roquilly, J. Villadangos, Hamish E. G. McWilliam   +31 more
semanticscholar   +1 more source

MAIT Cells in Health and Disease

2019
Mucosal-associated invariant T (MAIT) cells are a newly described subset of T cells that are found in the blood and are enriched in many tissues, particularly in the liver. MAIT cells express a semi-invariant T cell receptor restricted by the MHC class I-related (MR1) molecule. MAIT cells are activated in a MR1-dependent manner in response to microbial-
Isabelle, Magalhaes, Martin, Solders, Helen, Kaipe   +2 more
openaire   +2 more sources

MAIT cell plasticity enables functional adaptation that drives antibacterial immune protection.

Science immunology
Mucosal-associated invariant T (MAIT) cells are known for their rapid effector functions and antibacterial immune protection. Here, we define the plasticity of interferon-γ (IFN-γ)-producing MAIT1 and interleukin-17A (IL-17A)-producing MAIT17 cell ...
Huimeng Wang, Michael N. T. Souter, Marcela de Lima Moreira, Shihan Li, Yuchen Zhou, Adam G. Nelson, Jinhan Yu, Lucy J Meehan, Bronwyn S. Meehan, S. Eckle, H. J. Lee, Jan Schröder, A. Haque, Jeffrey Y. W. Mak, David P. Fairlie, James McCluskey, Zhongfang Wang, Zhenjun Chen, A. Corbett   +18 more
semanticscholar   +1 more source

MAIT cells and pathogen defense

Cellular and Molecular Life Sciences, 2014
Mucosa-associated invariant T (MAIT) cells are a unique population of innate T cells that are abundant in humans. These cells possess an evolutionarily conserved invariant T cell receptor α chain restricted by the nonpolymorphic class Ib major histocompatibility (MHC) molecule, MHC class I-related protein (MR1). The recent discovery that MAIT cells are
openaire   +2 more sources

Restoration of IFN‐γ‐Producing MAIT Cell Correlates to Beneficial Allergen Immunotherapy in Allergic Rhinitis Patients

Clinical and Experimental Allergy
Mucosal‐associated invariant T cells (MAIT) are emerging as important regulators at mucosal surfaces. While these cells have been linked to a Th1‐biased immune response and support for B cells, their roles in allergic diseases characterised by type 2 ...
Ying Jiang, Xin Wang, Qing Jiang, Hao Chen, Lin Yang, Wei Wang, Junmei Weng, Mi Wu, Ting Zhou, Yin Yao, Shuyan Guo, Jin Xiong, Xiang Lu, Rongfei Zhu, Xiufang Weng   +14 more
semanticscholar   +1 more source