Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Transcriptome sequencing analysis of maize embryonic callus during early redifferentiation
Background Maize is one of the primary crops of genetic manipulation, which provides an excellent means of promoting stress resistance and increasing yield.
Xiaoling Zhang +11 more
doaj +1 more source
An integrated molecular and conventional breeding scheme for enhancing genetic gain in maize in Africa [PDF]
Open Access Journal; Published online: 06 Nov 2019Maize production in West and Central Africa (WCA) is constrained by a wide range of interacting stresses that keep productivity below potential yields.
Gedil, M., Menkir, A.
core +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Intercropping of soybean and proso millet for biomass production [PDF]
Sustainable agriculture considers production of high quality food and feed with minimal impact on environment. Intercropping is one of the most efficient ways to produce valuable biomass for animal feed rich in nutrients.
Milenković Milena +5 more
doaj +1 more source
Techno-Economic Analysis of a Crossflow Column Dryer for Maize Drying in Ghana [PDF]
George Obeng-Akrofi +3 more
openalex +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Change in seed viability of commercial maize hybrids during storage [PDF]
The production and processing of commercial seeds place significant emphasis on seed quality, with germination rates being a critical determinant of market performance.
Perić Sanja +5 more
doaj +1 more source
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Response of Quality Protein Maize (QPM) hybrids for grain yield in diverse environments
Genotype (G) × environment (E) interaction is very important for the evaluation of cultivars in breeding programmes. Present study was conducted to assess the effect of environment and yield stability of 68 quality protein maize (QPM) hybrids at three ...
Ramesh Kumar +9 more
doaj +1 more source

