Results 71 to 80 of about 819,208 (356)

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Transcriptional targets of amyotrophic lateral sclerosis/frontotemporal dementia protein TDP-43 – meta-analysis and interactive graphical database

Disease Models & Mechanisms, 2022
Maize C. Cao, Emma L. Scotter
doaj   +1 more source

Bi-cropping fodder maize in an existing (grass)clover sward [PDF]

, 2006
Organic cultivation of fodder maize is still considered to be difficult. Weed pressure, soil structure degradation during harvest and low nutrient efficiency are some of the common problems.
Eekeren, N. van, Oomen, G.J.M., Prins, U.   +2 more
core  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Multi-trait association mapping for phosphorous efficiency reveals flexible root architectures in sorghum

BMC Plant Biology
Background On tropical regions, phosphorus (P) fixation onto aluminum and iron oxides in soil clays restricts P diffusion from the soil to the root surface, limiting crop yields. While increased root surface area favors P uptake under low-P availability,
Barbara Hufnagel, Karine C. Bernardino, Marcos Malosetti, Sylvia M. Sousa, Lidianne A. Silva, Claudia Teixeira Guimaraes, Antônio Marcos Coelho, Thiago Teixeira Santos, Joao H. M. Viana, Robert E. Schaffert, Leon V. Kochian, Fred A. Eeuwijk, Jurandir V. Magalhaes   +12 more
doaj   +1 more source

Identification of gray leaf spot–resistant donor lines in tropical maize germplasm and their agronomic performance under artificial inoculation

Frontiers in Plant Science
Gray leaf spot (GLS) disease is caused by two fungal pathogens, Cercospora zeae-maydis and Cercospora zeina. The current study evaluated 427 elite tropical/subtropical lines for their responses to GLS under artificial inoculation in Kakamega in western ...
L. M. Suresh, Manje Gowda, Yoseph Beyene, Dan Makumbi, Kulai Amadu Manigben, Kulai Amadu Manigben, Kulai Amadu Manigben, Juan Burgueño, Robert Okayo, Vincent W. Woyengo, Boddupalli M. Prasanna   +10 more
doaj   +1 more source

Characterization of phytohormone and transcriptome reprogramming profiles during maize early kernel development

BMC Plant Biology, 2019
Background During maize early kernel development, the dramatic transcriptional reprogramming determines the rate of developmental progression, and phytohormone plays critical role in these important processes.
Chuanyu Ma, Bo Li, Lina Wang, Ming-liang Xu, E. Lizhu, Hongyu Jin, Zhicheng Wang, Jian-rong Ye   +7 more
doaj   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

The United States Love Affair with Maize: A National Security Issue?

, 2020
Maize is the most widely grown crop in the United States. The crop has a variety of applications being used for food, fuel, and in some industries. Maize is heavily integrated into the fabric of billions of lives across the world.
Kelly, Jared
core