Results 71 to 80 of about 668,342 (306)

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Multi-trait association mapping for phosphorous efficiency reveals flexible root architectures in sorghum

BMC Plant Biology
Background On tropical regions, phosphorus (P) fixation onto aluminum and iron oxides in soil clays restricts P diffusion from the soil to the root surface, limiting crop yields. While increased root surface area favors P uptake under low-P availability,
Barbara Hufnagel, Karine C. Bernardino, Marcos Malosetti, Sylvia M. Sousa, Lidianne A. Silva, Claudia Teixeira Guimaraes, Antônio Marcos Coelho, Thiago Teixeira Santos, Joao H. M. Viana, Robert E. Schaffert, Leon V. Kochian, Fred A. Eeuwijk, Jurandir V. Magalhaes   +12 more
doaj   +1 more source

Efficacy of Transgenic Maize LD05 Against Fall Armyworm (Spodoptera frugiperda)

Plants
The fall armyworm (Spodoptera frugiperda (J.E. Smith)), which invaded China in 2018, has caused severe corn yield losses and increased pesticide application frequency.
Wenlan Li, Xiang Gao, Xinwei Hou, Zhaohua Ding, Zhaodong Meng, Runqing Yue   +5 more
doaj   +1 more source

Bi-cropping fodder maize in an existing (grass)clover sward [PDF]

, 2006
Organic cultivation of fodder maize is still considered to be difficult. Weed pressure, soil structure degradation during harvest and low nutrient efficiency are some of the common problems.
Eekeren, N. van, Oomen, G.J.M., Prins, U.   +2 more
core  

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Identification of gray leaf spot–resistant donor lines in tropical maize germplasm and their agronomic performance under artificial inoculation

Frontiers in Plant Science
Gray leaf spot (GLS) disease is caused by two fungal pathogens, Cercospora zeae-maydis and Cercospora zeina. The current study evaluated 427 elite tropical/subtropical lines for their responses to GLS under artificial inoculation in Kakamega in western ...
L. M. Suresh, Manje Gowda, Yoseph Beyene, Dan Makumbi, Kulai Amadu Manigben, Kulai Amadu Manigben, Kulai Amadu Manigben, Juan Burgueño, Robert Okayo, Vincent W. Woyengo, Boddupalli M. Prasanna   +10 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Coping with Ex-ante Regulations for Planting Bt Maize: The Portuguese Experience [PDF]

, 2009
This article investigates the attitude and practices of Bt and non-Bt maize farmers in Portugal. Thirty-seven Bt maize farmers were interviewed, representing 22.5% of the total number of Bt maize notifications in the country and 31.5% of the total area ...
Fevereiro, P., Skevas, T., Wesseler, J.H.H.   +2 more
core   +3 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Maize Revolutions in Sub-Saharan Africa [PDF]

There have been numerous episodes of widespread adoption of improved seed and long-term achievements in the development of the maize seed industry in Sub-Saharan Africa.
Byerlee, Derek R., Jayne, Thomas S., Smale, Melinda   +2 more
core   +4 more sources