Major depressive disorder [PDF]
Nature Reviews Disease Primers, 2016 Major depressive disorder (MDD) is a debilitating disease that is characterized by depressed mood, diminished interests, impaired cognitive function and vegetative symptoms, such as disturbed sleep or appetite. MDD occurs about twice as often in women than it does in men and affects one in six adults in their lifetime.
Otte, Christian +7 more
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Major Depressive Disorder [PDF]
Neuron, 2000 In summary, MDD is a highly prevalent major medical whose pathophysiology is still poorly understood. MDD is often recurrent or chronic, and evidence suggests that genetic factors partially influence overall risk of illness but also influence the sensitivity of individuals to the depressogenic effects of environmental adversity.
Fava, Maurizio, Kendler, Kenneth S
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Nitrous Oxide in Treatment Resistant Major Depression: Should We Laugh About It?
European Psychiatry, 2022 Introduction Nitrous oxide (NO), also known as “laughing gas” is a colorless gas used as an anesthetic, a propellant in some foods, an engine performance enhancer and a recreational drug.
B. Leal +7 more
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Validation of the face-name pairs task in major depression: impaired recall but not recognition [PDF]
, 2014 Major depression can be associated with neurocognitive deficits which are believed in part to be related to medial temporal lobe pathology. The purpose of this study was to investigate this impairment using a hippocampal-dependent neuropsychological task.
McLoughlin, D +3 more
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Keeping company with hope and despair. Family therapists' reflections and experience of working with childhood depression [PDF]
, 2007 The BIOMED international outcome study on childhood depression offered a unique opportunity for the systematic treatment of children and families with major depression using systemic psychotherapy.
Angold +11 more
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Electroconvulsive therapy mediates neuroplasticity of white matter microstructure in major depression. [PDF]
, 2014 Whether plasticity of white matter (WM) microstructure relates to therapeutic response in major depressive disorder (MDD) remains uncertain. We examined diffusion tensor imaging (DTI) correlates of WM structural connectivity in patients receiving ...
Clark, K +7 more
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Cognitive conflicts in major depression : Between desired change and personal coherence [PDF]
, 2014 This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial ...
Abramson L. Y. +21 more
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The GoodNight study—online CBT for insomnia for the indicated prevention of depression: study protocol for a randomised controlled trial [PDF]
, 2016 BACKGROUND Cognitive Behaviour Therapy for Insomnia (CBT-I) delivered through the Internet is effective as a treatment in reducing insomnia in individuals seeking help for insomnia. CBT-I also lowers levels of depression in this group. However, it is not
Bennett, Anthony +9 more
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Dealing with major depression in general practice
South African Family Practice, 2013 One in ten South Africans will be diagnosed with major depressive disorder (MDD) at some point in their lives. MDD is a potentially disabling condition that affects many spheres of an individual’s life and leads to marked social and occupational ...
C.P. Freeman, J.A. Joska
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Altered hippocampal function in major depression despite intact structure and resting perfusion [PDF]
, 2016 Background: Hippocampal volume reductions in major depression have been frequently reported. However, evidence for functional abnormalities in the same region in depression has been less clear.
A. Finkelmeyer +18 more
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