Brain Sciences, 2022 Deficits in the executive control of attention greatly impact the quality of life of patients diagnosed with major depressive disorder (MDD). However, attentional deficits are often underemphasized in clinical contexts compared with mood-based symptoms ...
Alfredo Spagna +6 more
doaj +1 more source
Mirroring everyday clinical practice in clinical trial design: a new concept to improve the external validity of randomized double-blind placebo-controlled trials in the pharmacological treatment of major depression [PDF]
, 2012 Background: Randomized, double-blind, placebo-controlled trials constitute the gold standard in clinical research when testing the efficacy of new psychopharmacological interventions in the treatment of major depression.
A Cipriani +43 more
core +3 more sources
The GoodNight study—online CBT for insomnia for the indicated prevention of depression: study protocol for a randomised controlled trial [PDF]
, 2016 BACKGROUND Cognitive Behaviour Therapy for Insomnia (CBT-I) delivered through the Internet is effective as a treatment in reducing insomnia in individuals seeking help for insomnia. CBT-I also lowers levels of depression in this group. However, it is not
Bennett, Anthony +9 more
core +1 more source
Genetics of age-at-onset in major depression
Translational Psychiatry, 2022 Major depression (MD) is a complex, heterogeneous neuropsychiatric disorder. An early age at onset of major depression (AAO-MD) has been associated with more severe illness, psychosis, and suicidality. However, not much is known about what contributes to
Arvid Harder +5 more
doaj +1 more source
Dealing with major depression in general practice
South African Family Practice, 2012 One in ten South Africans will be diagnosed with major depressive disorder (MDD) at some point in their lives. MDD is a potentially disabling condition that affects many spheres of an individual’s life and leads to marked social and occupational ...
C.P. Freeman, J.A. Joska
doaj +1 more source
MicroRNAs as a new hope for depression
Psychiatry and Behavioral Sciences, 2015 Depression is a common and debilitating illness. Although a great deal of research has been done in the area, its neurobiology remains unclear. MicroRNAs are 22 nucleotides long and usually prevent protein synthesis from mRNAs at several stages.
Mehmet Akif Camkurt
doaj +1 more source
Neuroactive steroids in depression and anxiety disorders: Clinical studies [PDF]
, 2006 Certain neuroactive steroids modulate ligand-gated ion channels via non-genomic mechanisms. Especially 3 alpha-reduced pregnane steroids are potent positive allosteric modulators of the gamma-aminobutyric acid type A (GABA(A)) receptor.
Akwa Y +79 more
core +1 more source
Substance Use and Depression Symptomatology: Measurement Invariance of the Beck Depression Inventory (BDI-II) among Non-Users and Frequent-Users of Alcohol, Nicotine and Cannabis [PDF]
, 2016 Depression is a highly heterogeneous condition, and identifying how symptoms present in various groups may greatly increase our understanding of its etiology.
Moore, Ashlee A. +3 more
core +4 more sources
Event-Related Potentials in Major Depression [PDF]
Düşünen Adam Psikiyatri ve Nörolojik Bilimler Dergisi, 2005 Objective: Patients with major depression often have psychomotor retardation, reduced mental processing speed, inability to make decision. These symptoms may be mediated in prefrontal abnormalities (cortico-striato-pallido-thalamo-cortical pathway). This
Mustafa Karagöz +4 more
doaj
Depressão maior suscita questionamento maior Major depression invites major concerns
Brazilian Journal of Psychiatry, 2009 OBJETIVO: Revisar as limitações do conceito e do construto da depressão maior. MÉTODO: Os objetivos na conceitualização inicial da depressão maior são examinados em relação à sua subseqüente utilidade e relevância para os clínicos e pesquisadores ...
Gordon Parker, Heather Brotchie
doaj +1 more source