Results 31 to 40 of about 642,062 (263)

Molecular Signatures of Major Depression [PDF]

Current Biology, 2015
Adversity, particularly in early life, can cause illness. Clues to the responsible mechanisms may lie with the discovery of molecular signatures of stress, some of which include alterations to an individual's somatic genome. Here, using genome sequences from 11,670 women, we observed a highly significant association between a stress-related disease ...
Cai, Na, Chang, Simon, Li, Yihan, Li, Qibin, Hu, Jingchu, Liang, Jieqin, Song, Li, Kretzschmar, Warren, Gan, Xiangchao, Nicod, Jerome, Rivera, Margarita, Deng, Hong, Du, Bo, Li, Keqing, Sang, Wenhu, Gao, Jingfang, Gao, Shugui, Ha, Baowei, Ho, Hung-Yao, Hu, Chunmei, Hu, Jian, Hu, Zhenfei, Huang, Guoping, Jiang, Guoqing, Jiang, Tao, Jin, Wei, Li, Gongying, Li, Kan, Li, Yi, Li, Yingrui, Li, Youhui, Lin, Yu-Ting, Liu, Lanfen, Liu, Tiebang, Liu, Ying, Liu, Yuan, Lu, Yao, Lv, Luxian, Meng, Huaqing, Qian, Puyi, Sang, Hong, Shen, Jianhua, Shi, Jianguo, Sun, Jing, Tao, Ming, Wang, Gang, Wang, Guangbiao, Wang, Jian, Wang, Linmao, Wang, Xueyi, Wang, Xumei, Yang, Huanming, Yang, Lijun, Yin, Ye, Zhang, Jinbei, Zhang, Kerang, Sun, Ning, Zhang, Wei, Zhang, Xiuqing, Zhang, Zhen, Zhong, Hui, Breen, Gerome, Wang, Jun, Marchini, Jonathan, Chen, Yiping, Xu, Qi, Xu, Xun, Mott, Richard, Huang, Guo-Jen, Kendler, Kenneth, Flintl, Jonathan   +70 more
openaire   +8 more sources

Motor imagery in unipolar major depression

Frontiers in Behavioral Neuroscience, 2014
Background: Motor imagery is a potential tool to investigate action representation, as it can provide insights into the processes of action planning and preparation.
Djamila eBennabi, julie emonnin, julie emonnin, Emmanuel eHaffen, Emmanuel eHaffen, Emmanuel eHaffen, Emmanuel eHaffen, Nicolas eCarvalho, Nicolas eCarvalho, Pierre eVandel, Pierre eVandel, Thierry ePozzo, Thierry ePozzo, Thierry ePozzo, Charalambos ePAPAXANTHIS, Charalambos ePAPAXANTHIS   +15 more
doaj   +1 more source

Benchmarking post-GWAS analysis tools in major depression: Challenges and implications

Frontiers in Genetics, 2022
Our knowledge of complex disorders has increased in the last years thanks to the identification of genetic variants (GVs) significantly associated with disease phenotypes by genome-wide association studies (GWAS).
Judith Pérez-Granado, Janet Piñero, Janet Piñero, Laura I. Furlong, Laura I. Furlong   +4 more
doaj   +1 more source

“We Cannot Talk as a Family”: Complexities of Survivorship Communication Among Hispanic/Latino Young Adult Survivors of Childhood Cancer, Parents, and Clinicians

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Young adult childhood cancer survivors (YA‐CCS) have an increased risk of treatment‐related health complications throughout their lives. Lifelong survivorship care is recommended, yet many YA‐CCS experience disruptions in care during pediatric‐to‐adult transitions and do not receive recommended survivorship care.
Kevin Shanchen Pu, Nicole Fernández‐Viña, Briana C. Martin‐Villa, Daniela Ramirez, Rebecca M. Lewinsohn, Mary Smith, Heidi Boynton, Lidia Schapira, Stephanie M. Smith   +8 more
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Comparing the Effect of Semi‐Immersive Virtual Reality, Computerized Cognitive Training, and Traditional Rehabilitation on Cognitive Function in Multiple Sclerosis: A Randomized Clinical Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Cognitive impairment is a common non‐motor symptom in Multiple Sclerosis (MS), negatively affecting autonomy and Quality of Life (QoL). Innovative rehabilitation strategies, such as semi‐immersive virtual reality (VR) and computerized cognitive training (CCT), may offer advantages over traditional cognitive rehabilitation (TCR ...
Maria Grazia Maggio, Desiree Latella, Lilla Bonanno, Paulo Cezar Rocha dos Santos, Marcos Maldonado‐Díaz, Meir Plotnik, Rosaria De Luca, Angelo Quartarone, Rocco Salvatore Calabrò   +8 more
wiley   +1 more source

Blood Brain-Derived Neurotrophic Factor (BDNF) and Major Depression: Do We Have a Translational Perspective?

Frontiers in Behavioral Neuroscience, 2021
Major depressive disorder (MDD) affects millions of people worldwide and is a leading cause of disability. Several theories have been proposed to explain its pathological mechanisms, and the “neurotrophin hypothesis of depression” involves one of the ...
Beatrice Arosio, Beatrice Arosio, Franca Rosa Guerini, Richard C. Oude Voshaar, Ivan Aprahamian, Ivan Aprahamian   +5 more
doaj   +1 more source

Memory and Resting‐State Connectivity in Acute Transient Global Amnesia: A Case–Control fMRI Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Transient global amnesia (TGA) is a striking model of isolated amnesia. While hippocampal lesions are well described, the network‐level mechanisms and the precise neuropsychological profile remain debated. Our objective was thus to characterize functional and neuropsychological correlates of acute TGA and their ...
Elias El Otmani, Emmanuel Barbeau, Béatrice Lemesle, Emilie Milongo‐Rigal, Sophie Fernandez, Sandrine Charpentier, Jean‐François Albucher, Nicolas Raposo, Fabrice Bonneville, Patrice Péran, Jérémie Pariente   +10 more
wiley   +1 more source

Cross-Disorder Genomics Data Analysis Elucidates a Shared Genetic Basis Between Major Depression and Osteoarthritis Pain

Frontiers in Genetics, 2021
Osteoarthritis (OA) and major depression (MD) are two debilitating disorders that frequently co-occur and affect millions of the elderly each year. Despite the greater symptom severity, poorer clinical outcomes, and increased mortality of the comorbid ...
Sophie Barowsky, Jae-Yoon Jung, Nicholas Nesbit, Micah Silberstein, Maurizio Fava, Maurizio Fava, Maurizio Fava, Marco L. Loggia, Jordan W. Smoller, Jordan W. Smoller, Jordan W. Smoller, Phil H. Lee, Phil H. Lee, Phil H. Lee   +13 more
doaj   +1 more source