Distinguish bipolar and major depressive disorder in adolescents based on multimodal neuroimaging: Results from the Adolescent Brain Cognitive Development study [PDF]
Digital Health, 2022 Background Major depressive disorder and bipolar disorder in adolescents are prevalent and are associated with cognitive impairment, executive dysfunction, and increased mortality. Early intervention in the initial stages of major depressive disorder and
Yujun Liu +9 more
doaj +4 more sources
Metacognitive deficits in major depressive disorder [PDF]
Frontiers in PsychiatryObjectiveWe aimed to investigate the metacognition of patients with major depressive disorder (MDD) and its correlation with their condition, as well as explore its diagnostic significance in the early stages of the disease, thereby providing a reference
Shuning Hong +5 more
doaj +2 more sources
Brain aging in major depressive disorder: results from the ENIGMA major depressive disorder working group [PDF]
bioRxiv, 2019 Major depressive disorder (MDD) is associated with an increased risk of brain atrophy, aging-related diseases, and mortality. We examined potential advanced brain aging in adult MDD patients, and whether this process is associated with clinical ...
Laura K. M. Han +145 more
semanticscholar +5 more sources
Sparse whole genome sequencing identifies two loci for major depressive disorder [PDF]
Nature, 2015 Major depressive disorder (MDD), one of the most frequently encountered forms of mental illness and a leading cause of disability worldwide, poses a major challenge to genetic analysis.
N. Cai +104 more
semanticscholar +4 more sources
The Economic Burden of Adults with Major Depressive Disorder in the United States (2010 and 2018)
PharmacoEconomics (Auckland), 2021 The incremental economic burden of US adults with major depressive disorder (MDD) was estimated at $US210.5 billion in 2010 (year 2012 values). Following a similar methodology, this study updates the previous findings with more recent data to report the ...
P. Greenberg +6 more
semanticscholar +1 more source
Efficacy of Ketamine as an Adjuvant to Antidepressants in the Treatment of Depression [PDF]
Journal of Clinical and Diagnostic Research, 2021 Introduction: Depression is the second leading cause of morbidity worldwide. Currently, available antidepressants mostly target the monoamine system. The onset of action and response rates for these antidepressants are varied.
Hrishikesh Solunke +4 more
doaj +1 more source
Single-Dose Psilocybin Treatment for Major Depressive Disorder: A Randomized Clinical Trial.
Journal of the American Medical Association (JAMA), 2023 Importance Psilocybin shows promise as a treatment for major depressive disorder (MDD). Objective To evaluate the magnitude, timing, and durability of antidepressant effects and safety of a single dose of psilocybin in patients with MDD.
C. Raison +33 more
semanticscholar +1 more source
Molecular Psychiatry, 2022 The emerging understanding of gut microbiota as ‘metabolic machinery’ influencing many aspects of physiology has gained substantial attention in the field of psychiatry. This is largely due to the many overlapping pathophysiological mechanisms associated
A. McGuinness +15 more
semanticscholar +1 more source
Molecular pathways of major depressive disorder converge on the synapse
Molecular Psychiatry, 2022 Major depressive disorder (MDD) is a psychiatric disease of still poorly understood molecular etiology. Extensive studies at different molecular levels point to a high complexity of numerous interrelated pathways as the underpinnings of depression. Major
G. Fries +3 more
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