Results 11 to 20 of about 832,143 (393)
Sparse whole genome sequencing identifies two loci for major depressive disorder [PDF]
Nature, 2015 Major depressive disorder (MDD), one of the most frequently encountered forms of mental illness and a leading cause of disability worldwide, poses a major challenge to genetic analysis.
N. Cai +104 more
semanticscholar +4 more sources
The Economic Burden of Adults with Major Depressive Disorder in the United States (2010 and 2018)
PharmacoEconomics (Auckland), 2021 The incremental economic burden of US adults with major depressive disorder (MDD) was estimated at $US210.5 billion in 2010 (year 2012 values). Following a similar methodology, this study updates the previous findings with more recent data to report the ...
P. Greenberg +6 more
semanticscholar +1 more source
Single-Dose Psilocybin Treatment for Major Depressive Disorder: A Randomized Clinical Trial.
Journal of the American Medical Association (JAMA), 2023 Importance Psilocybin shows promise as a treatment for major depressive disorder (MDD). Objective To evaluate the magnitude, timing, and durability of antidepressant effects and safety of a single dose of psilocybin in patients with MDD.
C. Raison +33 more
semanticscholar +1 more source
The genetic basis of major depressive disorder
Molecular Psychiatry, 2023 The genetic dissection of major depressive disorder (MDD) ranks as one of the success stories of psychiatric genetics, with genome-wide association studies (GWAS) identifying 178 genetic risk loci and proposing more than 200 candidate genes. However, the
J. Flint
semanticscholar +1 more source
Efficacy of Ketamine as an Adjuvant to Antidepressants in the Treatment of Depression [PDF]
Journal of Clinical and Diagnostic Research, 2021 Introduction: Depression is the second leading cause of morbidity worldwide. Currently, available antidepressants mostly target the monoamine system. The onset of action and response rates for these antidepressants are varied.
Hrishikesh Solunke +4 more
doaj +1 more source
Treating depressive disorders with the unified protocol: A preliminary randomized evaluation. [PDF]
, 2020 OBJECTIVES: This study aims to examine the efficacy of the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders (UP) for individuals diagnosed with a depressive disorder. METHOD: Participants included 44 adults who met criteria for major
Ametaj, Amantia A. +9 more
core +2 more sources
Molecular Psychiatry, 2022 The emerging understanding of gut microbiota as ‘metabolic machinery’ influencing many aspects of physiology has gained substantial attention in the field of psychiatry. This is largely due to the many overlapping pathophysiological mechanisms associated
A. McGuinness +15 more
semanticscholar +1 more source
Molecular pathways of major depressive disorder converge on the synapse
Molecular Psychiatry, 2022 Major depressive disorder (MDD) is a psychiatric disease of still poorly understood molecular etiology. Extensive studies at different molecular levels point to a high complexity of numerous interrelated pathways as the underpinnings of depression. Major
G. Fries +3 more
semanticscholar +1 more source
C-Reactive Protein as a Biomarker for Major Depressive Disorder?
International Journal of Molecular Sciences, 2022 The etiopathogenesis of depression is not entirely understood. Several studies have investigated the role of inflammation in major depressive disorder. The present work aims to review the literature on the association between C-Reactive Protein (CRP) and
L. Orsolini +4 more
semanticscholar +1 more source
Translational Psychiatry, 2021 Psilocybin has shown promise for the treatment of mood disorders, which are often accompanied by cognitive dysfunction including cognitive rigidity.
Manoj K. Doss +10 more
semanticscholar +1 more source