Results 21 to 30 of about 193,331 (298)

A gene co-expression network-based analysis of multiple brain tissues reveals novel genes and molecular pathways underlying major depression.

PLoS Genetics, 2019
Major depression is a common and severe psychiatric disorder with a highly polygenic genetic architecture. Genome-wide association studies have successfully identified multiple independent genetic loci that harbour variants associated with major ...
Zachary F Gerring, Eric R Gamazon, Eske M Derks, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium   +3 more
doaj   +1 more source

Patient-reported outcomes in major depressive disorder with suicidal ideation: a real-world data analysis using PatientsLikeMe platform

BMC Psychiatry, 2020
Background The current analysis utilized data collected via an online patient community platform, PatientsLikeMe (PLM) to compare patient-reported experiences in patients with major depressive disorder (MDD) with suicidal ideation (MDSI) to those with ...
Stephane Borentain, Abigail I. Nash, Rachna Dayal, Allitia DiBernardo   +3 more
doaj   +1 more source

Serum level of soluble interleukin 6 receptor is a useful biomarker for identification of treatment‐resistant major depressive disorder

Neuropsychopharmacology Reports, 2020
Aim A substantial proportion of major depressive disorder patients are treatment‐resistant to antidepressant therapy, who require augmentation drugs, or other treatments including electroconvulsive therapy or transcranial magnetic stimulation ...
Katsuhiko Yamasaki, Tomonori Hasegawa, Masatoshi Takeda   +2 more
doaj   +1 more source

Depression: Special Considerations for the Dental Setting

MedEdPORTAL, 2011
The 1-year prevalence rate for depression is 9.5%, or approximately 20.9 million adults in America. The lifetime prevalence of major depressive disorder is approximately 10%-25%.
Jessica G. Hinz
doaj   +1 more source

SUMOylation and Major Depressive Disorder

International Journal of Molecular Sciences, 2022
Since the discovery of the small ubiquitin-like modifier (SUMO) protein in 1995, SUMOylation has been considered a crucial post-translational modification in diverse cellular functions. In neurons, SUMOylation has various roles ranging from managing synaptic transmitter release to maintaining mitochondrial integrity and determining neuronal health.
Seok-Won Jeoung, Hyun-Sun Park, Zae Young Ryoo, Dong-Hyung Cho, Hyun-Shik Lee, Hong-Yeoul Ryu   +5 more
openaire   +2 more sources

Depression from the perspective of modern and Persian medicine

Electronic Physician, 2018
Background: Depression is one of the five most-common diseases globally, and is expected to be the second leading cause of disability by 2020 and its economic and social burden is a major problem worldwide Objective: The aim of this research was to ...
Majid Anushiravani, Ali Akhondpour Manteghi, Ali Taghipur, Mahdi Eslami   +3 more
doaj   +1 more source

Retinoid homeostasis in major depressive disorder

Translational Psychiatry, 2023
The small, hormone-like molecule retinoic acid (RA) is a vital regulator in several neurobiological processes that are affected in depression. Next to its involvement in dopaminergic signal transduction, neuroinflammation, and neuroendocrine regulation ...
Lisa Rebecca Otto, Vera Clemens, Berk Üsekes, Nicoleta Carmen Cosma, Francesca Regen, Julian Hellmann-Regen   +5 more
doaj   +1 more source

Epigenetic prediction of major depressive disorder [PDF]

Molecular Psychiatry, 2020
AbstractVariation in DNA methylation (DNAm) is associated with lifestyle factors such as smoking and body mass index (BMI) but there has been little research exploring its ability to identify individuals with major depressive disorder (MDD). Using penalised regression on genome-wide CpG methylation, we tested whether DNAm risk scores (MRS), trained on ...
Ian J. Deary, David J. Porteous, Heather C. Whalley, Toni-Kim Clarke, Xueyi Shen, Kathryn L. Evans, David M. Howard, David M. Howard, Andrew M. McIntosh, Stewart W. Morris, Yanni Zeng, Riccardo E. Marioni, Rosie M. Walker, Miruna C. Barbu   +13 more
openaire   +7 more sources

Cell‐free and extracellular vesicle microRNAs with clinical utility for solid tumors

Molecular Oncology, EarlyView.
Cell‐free microRNAs (cfmiRs) are small‐RNA circulating molecules detectable in almost all body biofluids. Innovative technologies have improved the application of cfmiRs to oncology, with a focus on clinical needs for different solid tumors, but with emphasis on diagnosis, prognosis, cancer recurrence, as well as treatment monitoring.
Yoshinori Hayashi, Janelle‐Cheri Millen, Romela Irene Ramos, Jennifer A. Linehan, Timothy G. Wilson, Dave S. B. Hoon, Matias A. Bustos   +6 more
wiley   +1 more source

CNS Mitochondria‐Derived Vesicle in Blood: Potential Biomarkers for Brain Mitochondria Dysfunction

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial dysfunction is a hallmark of neurodegenerative diseases like Alzheimer's (AD) and Parkinson's (PD). Our goal was to develop practical, noninvasive methods to assess mitochondrial status through the detection of mitochondria‐derived vesicles (MDVs).
Qi Liu, Wentao Chen, Yahong Wu, Zhen Guo, Jun Chen, Chen Tian, Pan Wang, Shaopeng Zeng, Bin Xu, Jing Duan, Shilong Han, Xiao Xiong, Jing Zhang   +12 more
wiley   +1 more source