Results 211 to 220 of about 239,963 (355)

pMHChat, characterizing the interactions between major histocompatibility complex class II molecules and peptides with large language models and deep hypergraph learning. [PDF]

Brief Bioinform
Ma J, Wang Z, Tong C, Yang Q, Zhang L, Liu H.   +5 more
europepmc   +1 more source

Biomolecular Interaction Prediction in the Pre‐ and Post‐AlphaFold Era: The 8th CAPRI Evaluation

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT We report on the 8th CAPRI Evaluation period, capturing the assessment of CAPRI Rounds 47 to 55 (excluding the CASP and COVID‐related Rounds), which have witnessed the transition to AI‐driven prediction tools such as AlphaFold and related alternatives. The prediction Rounds in this evaluation are characterized by a high level of difficulty due
Marc F. Lensink, Nessim Raouraoua, Guillaume Brysbaert, Sameer Velankar, Shoshana J. Wodak, Alexandre M. J. J. Bonvin   +5 more
wiley   +1 more source

Regulation of major histocompatibility complex class-I (MHC-I) gene methylation using DNA methyltransferase inhibitor and PD-L1 inhibitor in triple negative breast cancer. [PDF]

Discov Oncol
Jeong YJ, Lee NR, Oh HK.
europepmc   +1 more source

Rationalizing Enhanced Affinity of Engineered T‐Cell Receptors in Cancer Immunotherapy Through Interaction Energy Calculations and Residue Correlation Analysis

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The advancement of T cell engineering has significantly transformed the field of cancer immunotherapy. In particular, T cells equipped with modified T cell receptors present a promising therapeutic strategy, especially for addressing solid tumors.
Mario Frezzini, Daniele Narzi
wiley   +1 more source

Using major histocompatibility complex (MHC) II expression to predict antitumor response to CD4 + lymphocyte depletion. [PDF]

Sci Rep
Wang Y, Kim M, Su S, Halwatura L, You S, Kim HL.   +5 more
europepmc   +1 more source

Functional isotypes are not encoded by the constant region genes of the beta subunit of the T cell receptor for antigen/major histocompatibility complex. [PDF]

, 1984
H D Royer, Armand Bensussan, Oreste Acuto, Ellis L. Reinherz   +3 more
openalex   +1 more source

A Multiple‐Model‐Informed Drug‐Development Approach for Optimal Regimen Selection of an Oncolytic Virus in Combination With Pembrolizumab

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 572-582, March 2025.
ABSTRACT The antitumor efficacy of an intratumoral injection of a genetically engineered oncolytic vaccinia virus carrying human IL‐7 and murine IL‐12 genes (hIL‐7/mIL‐12‐VV) was demonstrated in CT26.WT‐bearing mice. In the CT26.WT‐bearing mouse model, the efficacy of the combination of hIL‐7/mIL‐12‐VV plus the anti‐programmed cell death protein (PD)‐1
Akihiro Yamada, Mary P. Choules, Frances A. Brightman, Shigeru Takeshita, Shinsuke Nakao, Nobuaki Amino, Takeshi Nakayama, Masato Takeuchi, Kanji Komatsu, Fernando Ortega, Hitesh Mistry, David Orrell, Christophe Chassagnole, Peter L. Bonate   +13 more
wiley   +1 more source

The 2024 IPD-MHC database update: a comprehensive resource for major histocompatibility complex studies. [PDF]

Nucleic Acids Res
Maccari G, Robinson J, Barker DJ, Yates AD, Hammond JA, Marsh SGE.   +5 more
europepmc   +1 more source

Trans-acting element(s) operating across species barriers positively regulate expression of major histocompatibility complex class II genes.

, 1985
Roberto S. Accolla, Léonardo Scarpellino, Giovanna Carrà, John Guardiola   +3 more
openalex   +1 more source

Mathematical Modeling of Neuroinflammation in Neurodegenerative Diseases

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Age‐related neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD) and Parkinson's disease (PD) are an increasing public health concern. Whereas the pathology of these diseases is complex, chronic central inflammation, or neuroinflammation, is commonly observed across many neurodegenerative diseases ...
Alex Foster‐Powell, Amin Rostami‐Hodjegan, Guy Meno‐Tetang, Donald E. Mager, Kayode Ogungbenro   +4 more
wiley   +1 more source