Results 1 to 10 of about 96,655 (307)

Cohesin Regulates MHC Class II Genes through Interactions with MHC Class II Insulators [PDF]

The Journal of Immunology, 2011
Abstract Cohesin is a multiprotein, ringed complex that is most well-known for its role in stabilizing the association of sister chromatids between S phase and M. More recently, cohesin was found to be associated with transcriptional insulators, elements that are associated with the organization of chromatin into regulatory domains.
Parimal, Majumder, Jeremy M, Boss
openaire   +4 more sources

Gene duplication and fragmentation in the zebra finch major histocompatibility complex [PDF]

BMC Biology, 2010
Background Due to its high polymorphism and importance for disease resistance, the major histocompatibility complex (MHC) has been an important focus of many vertebrate genome projects. Avian MHC organization is of particular interest because the chicken
Burt David W, Kotkiewicz Holly, Godinez Ricardo, Westerdahl Helena, Völker Martin, Ekblom Robert, Balakrishnan Christopher N, Graves Tina, Griffin Darren K, Warren Wesley C, Edwards Scott V   +10 more
doaj   +3 more sources

MHC Class II and Non-MHC Class II Genes Differentially Influence Humoral Immunity to Bacillus anthracis Lethal Factor and Protective Antigen [PDF]

Toxins, 2012
Anthrax Lethal Toxin consists of Protective Antigen (PA) and Lethal Factor (LF), and current vaccination strategies focus on eliciting antibodies to PA. In human vaccination, the response to PA can vary greatly, and the response is often directed toward ...
Judith A. James, A. Darise Farris, Melissa L. Nguyen, Philip M. Cox, Sherry R. Crowe, Eric K. Dumas, Sridevi Kurella, Jonathan J. Hunt, Lori Garman   +8 more
doaj   +2 more sources

The primate Major Histocompatibility Complex as a case study of gene family evolution [PDF]

eLife
Gene families are groups of evolutionarily related genes. One large gene family that has experienced rapid evolution lies within the Major Histocompatibility Complex (MHC), whose proteins serve critical roles in innate and adaptive immunity.
Alyssa Lyn Fortier, Jonathan K Pritchard
doaj   +2 more sources

Lack of association between alopecia areata and HLA class I and II in a southeastern Brazilian population [PDF]

Anais Brasileiros de Dermatologia, 2016
: Background: Alopecia areata (AA) is a common disorder of unknown etiology that affects approximately 0.7% to 3.8% of patients among the general population. Currently, genetic and autoimmune factors are emphasized as etiopathogenic.
Ângela Marques Barbosa, Luiz Euribel Prestes-Carneiro, Aldri Roberta Sodoschi Sobral, Marcelo Jun Sakiyama, Bruna Cerávolo Lemos, Marilda Aparecida Milanez Morgado de Abreu, Luciana Leite Crivelin Martos, Ricardo Alberto Moliterno   +7 more
doaj   +1 more source

Atlantic cod (Gadus morhua) MHC I localizes to endolysosomal compartments independently of cytosolic sorting signals

Frontiers in Cell and Developmental Biology, 2023
Major histocompatibility complex (MHC) class I and II are crucial for the adaptive immune system because they are involved in peptide presentation to T cells.
Synne Arstad Bjørnestad, Monica Hongrø Solbakken, Kjetill S. Jakobsen, Sissel Jentoft, Oddmund Bakke, Cinzia Progida   +5 more
doaj   +1 more source

Allelic diversity and patterns of selection at the major histocompatibility complex class I and II loci in a threatened shorebird, the Snowy Plover (Charadrius nivosus)

BMC Evolutionary Biology, 2020
Background Understanding the structure and variability of adaptive loci such as the major histocompatibility complex (MHC) genes is a primary research goal for evolutionary and conservation genetics.
Medardo Cruz-López, Guillermo Fernández, Helen Hipperson, Eduardo Palacios, John Cavitt, Daniel Galindo-Espinosa, Salvador Gómez del Angel, Raya Pruner, Oscar Gonzalez, Terry Burke, Clemens Küpper   +10 more
doaj   +1 more source

Genetic diversity, evolution and selection in the major histocompatibility complex DRB and DQB loci in the family Equidae

BMC Genomics, 2020
Background The mammalian Major Histocompatibility Complex (MHC) is a genetic region containing highly polymorphic genes with immunological functions. MHC class I and class II genes encode antigen-presenting molecules expressed on the cell surface.
Marie Klumplerova, Petra Splichalova, Jan Oppelt, Jan Futas, Aneta Kohutova, Petra Musilova, Svatava Kubickova, Roman Vodicka, Ludovic Orlando, Petr Horin   +9 more
doaj   +1 more source

Major histocompatibility complex genomic investigation of endangered Chinese alligator provides insights into the evolution of tetrapod major histocompatibility complex and survival of critically bottlenecked species

Frontiers in Ecology and Evolution, 2022
BackgroundThe major histocompatibility complex (MHC) gene family, a vital immune gene family in vertebrates, helps animals defend against pathogens. The polymorphism of MHC genes is important for a species and is considered to be caused by the numerous ...
Ke He, Ke He, Ying Zhu, Ying Zhu, Shang-Chen Yang, Qing Ye, Qing Ye, Sheng-Guo Fang, Qiu-Hong Wan   +8 more
doaj   +1 more source

MHC-linked and un-linked class I genes in the wallaby [PDF]

, 2009
Background: MHC class I antigens are encoded by a rapidly evolving gene family comprising classical and non-classical genes that are found in all vertebrates and involved in diverse immune functions.
Wong, Emily S. W., Penny Coggill, Yuanyuan Cheng, Deakin Janine E, Katherine Belov, Hart, E., Janine E Deakin, Jennifer Harrow, Harrow Jennifer, Deakin, J.E., Cheng, Y., Beck, Stephan, Stephan Beck, Cheng, Yuanyuan, Hart, Elizabeth, Wong, Emily, Coggill, P., Deakin, Janine; id_orcid, Beck Stephan, Siddle, Hannah, Belov, K., Deakin, Janine E., Wong Emily SW, Hart Elizabeth, Wong, Emily Sw, Coggill Penny, Siddle, Hannah V., Wong, E.S.W., Coggill, Penny, Hannah V Siddle, Elizabeth Hart, Harrow, Jennifer, Beck, S., Cheng Yuanyuan, Harrow, J., Siddle Hannah V, Emily SW Wong, Belov Katherine, Siddle, H.V., Belov, Katherine   +39 more
core   +1 more source