Results 41 to 50 of about 162,844 (305)
The tammar wallaby major histocompatibility complex shows evidence of past genomic instability
BMC Genomics, 2011 Background The major histocompatibility complex (MHC) is a group of genes with a variety of roles in the innate and adaptive immune responses. MHC genes form a genetically linked cluster in eutherian mammals, an organization that is thought to confer ...
Harrow Jennifer +7 more
doaj +1 more source
Functional Characterization of a Chicken Major Histocompatibility Complex Class II B Gene Promoter [PDF]
, 1997 A 0.7 kilobase (kb) DNA fragment from the 5\u27 flanking region of a chicken major histocompatibility complex (MHC) class II B gene was cloned into chloramphenicol acetyltransferase (CAT) reporter vectors and was transfected into a chicken macrophage ...
Carpenter, Susan +5 more
core +3 more sources
Frontiers in Marine Science, 2023 The Patagonian moray cod, Muraenolepis orangiensis, belongs to the family Muraenolepididae and is the sole order of Gadiformes that inhabits the temperate and cold waters of the southern hemisphere.
Jinmu Kim +8 more
doaj +1 more source
Compartmentalization of MHC class II gene expression in transgenic mice [PDF]
Cell, 1988 A set of transgenic mouse lines carrying Ek alpha genes with promoter region deletions was created in an attempt to compartmentalize MHC class II gene expression. Fine immunohistological analyses established that one transgenic line is essentially devoid of E complex in the thymic cortex, another displays almost no E in the thymic medulla or on ...
W, van Ewijk +9 more
openaire +2 more sources
Gene duplication and fragmentation in the zebra finch major histocompatibility complex
BMC Biology, 2010 Background Due to its high polymorphism and importance for disease resistance, the major histocompatibility complex (MHC) has been an important focus of many vertebrate genome projects. Avian MHC organization is of particular interest because the chicken
Burt David W +10 more
doaj +1 more source
PLoS Biology, 2021 Viral diseases pose major threats to humans and other animals, including the billions of chickens that are an important food source as well as a public health concern due to zoonotic pathogens.
Samer Halabi +9 more
doaj +1 more source
PLoS Genetics, 2014 Genetic variation in the major histocompatibility complex (MHC) affects CD4∶CD8 lineage commitment and MHC expression. However, the contribution of specific genes in this gene-dense region has not yet been resolved.
Jonatan Tuncel +21 more
doaj +1 more source
Comparative Genomics of the Major Histocompatibility Complex (MHC) of Felids
Frontiers in Genetics, 2022 This review summarizes the current knowledge on the major histocompatibility complex (MHC) of the family Felidae. This family comprises an important domestic species, the cat, as well as a variety of free-living felids, including several endangered ...
Martin Plasil +7 more
doaj +1 more source
Modulation of Gene Expression by the MHC Class II Transactivator [PDF]
The Journal of Immunology, 2002 Abstract The class II transactivator (CIITA) is a master regulator of MHC class II expression. CIITA also modulates the expression of MHC class I genes, suggesting that it may have a more global role in gene expression. To determine whether CIITA regulates genes other than the MHC class II and I family, DNA microarray analysis was used ...
Uma M, Nagarajan +2 more
openaire +2 more sources
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source