Results 41 to 50 of about 96,655 (307)

Characterization of the major histocompatibility complex class II genes in miiuy croaker. [PDF]

PLoS ONE, 2011
Major histocompatibility complex (MHC) has a central role in the adaptive immune system by presenting foreign peptide to the T-cell receptor. In order to study the molecular function and genomic characteristic of class II genes in teleost, the full ...
Tianjun Xu, Yuena Sun, Ge Shi, Yuanzhi Cheng, Rixin Wang   +4 more
doaj   +1 more source

E5 protein of human papillomavirus type 16 selectively downregulates surface HLA class I [PDF]

, 2005
Papillomaviruses have evolved mechanisms that result in escape from host immune surveillance. The E5 protein is expressed early in papillomavirus infection in the deep layers of the infected epithelium.
Marchetti, Barbara, O'Brien, P.M., Ashrafi, G. Hossein, Haghshenas, Mohammad R., O'Brien, Philippa M., Ashrafi, G.H., Haghshenas, M.R., Campo, M.S., Marchetti, B., Campo, M. Saveria   +9 more
core   +1 more source

PML promotes MHC class II gene expression by stabilizing the class II transactivator [PDF]

Journal of Cell Biology, 2012
Promyelocytic leukemia (PML) nuclear bodies selectively associate with transcriptionally active genomic regions, including the gene-rich major histocompatibility (MHC) locus. In this paper, we have explored potential links between PML and interferon (IFN)-γ–induced MHC class II expression.
Ulbricht, Tobias, Alzrigat, Mohammad, Horch, Almut, Reuter, Nina, von Mikecz, Anna, Steimle, Viktor, Schmitt, Eberhard, Kraemer, Oliver H., Stamminger, Thomas, Hemmerich, Peter   +9 more
openaire   +3 more sources

Natural polymorphisms in Tap2 influence negative selection and CD4∶CD8 lineage commitment in the rat.

PLoS Genetics, 2014
Genetic variation in the major histocompatibility complex (MHC) affects CD4∶CD8 lineage commitment and MHC expression. However, the contribution of specific genes in this gene-dense region has not yet been resolved.
Jonatan Tuncel, Sabrina Haag, Anthony C Y Yau, Ulrika Norin, Amelie Baud, Erik Lönnblom, Klio Maratou, A Jimmy Ytterberg, Diana Ekman, Soley Thordardottir, Martina Johannesson, Alan Gillett, EURATRANS Consortium, Pernilla Stridh, Maja Jagodic, Tomas Olsson, Alberto Fernández-Teruel, Roman A Zubarev, Richard Mott, Timothy J Aitman, Jonathan Flint, Rikard Holmdahl   +21 more
doaj   +1 more source

The dominantly expressed class II molecule from a resistant MHC haplotype presents only a few Marek's disease virus peptides by using an unprecedented binding motif.

PLoS Biology, 2021
Viral diseases pose major threats to humans and other animals, including the billions of chickens that are an important food source as well as a public health concern due to zoonotic pathogens.
Samer Halabi, Michael Ghosh, Stefan Stevanović, Hans-Georg Rammensee, Luca D Bertzbach, Benedikt B Kaufer, Martin C Moncrieffe, Bernd Kaspers, Sonja Härtle, Jim Kaufman   +9 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Evolution of major histocompatibility complex class I and class II genes in the brown bear

BMC Evolutionary Biology, 2012
Background Major histocompatibility complex (MHC) proteins constitute an essential component of the vertebrate immune response, and are coded by the most polymorphic of the vertebrate genes.
Kuduk Katarzyna, Babik Wiesław, Bojarska Katarzyna, Śliwińska Ewa B, Kindberg Jonas, Taberlet Pierre, Swenson Jon E, Radwan Jacek   +7 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

A Physical Map Including a New Class I Gene (cda12) of the Human Major Histocompatibility Complex (A2/313 Haplotype) Derived from a Monosomy 6 Mutant Cell Line [PDF]

, 1989
To avoid interpretative problems due to restriction fragment length polymorphisms, the monosomy 6 mutant cell line BM19.7 was employed to establish a molecular map of the human major histocompatibility (HLA) complex in the A2,B13,Bw4,DRw6,DRw52,DQw1,DPw2
Pohla, Heike, Bloemer, K, Messer, Gerald, Bloemer, Katharina, Messer, G, Ziegler, Andreas, Ragoussis, Jiannis, Ragoussis, J, Weiss, Elisabeth H., Pohla, H, Weiss, EH, Ziegler, A   +11 more
core   +1 more source

Postoperative abdominal sepsis induces selective and persistent changes in CTCF binding within the MHC-II region of human monocytes.

PLoS ONE, 2021
BackgroundPostoperative abdominal infections belong to the most common triggers of sepsis and septic shock in intensive care units worldwide. While monocytes play a central role in mediating the initial host response to infections, sepsis-induced immune ...
Benedikt Hermann Siegler, Marc Altvater, Jan Niklas Thon, Jan Niklas Thon, Christopher Neuhaus, Christoph Arens, Florian Uhle, Christoph Lichtenstern, Markus Alexander Weigand, Sebastian Weiterer   +9 more
doaj   +1 more source