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The Structure of Human MHC Class II Genes
Autoimmunity, 1991 The class II molecules of the human major histocompatibility complex bind intracellularly processed peptides and present them to T-helper cells. They therefore have a critical role in the initiation of the immune response. A salient feature of the class II molecules is their polymorphism.
L, Rask +4 more
openaire +2 more sources
Antigen-presenting genes and genomic copy number variations in the Tasmanian devil MHC [PDF]
, 2015 BACKGROUND The Tasmanian devil (Sarcophilus harrisii) is currently under threat of extinction due to an unusual fatal contagious cancer called Devil Facial Tumour Disease (DFTD).
Amemiya, Chris T +8 more
core +4 more sources
F1000Research, 2018 This correspondence concerns a publication by Malmstrøm et al. in Nature Genetics in October 2016. Malmstrøm et al. made an important contribution to fish phylogeny research by using low-coverage genome sequencing for comparison of 66 teleost (modern ...
Johannes M. Dijkstra, Unni Grimholt
doaj +1 more source
Structure and polymorphism of the major histocompatibility complex class II region in the Japanese Crested Ibis, Nipponia nippon. [PDF]
PLoS ONE, 2014 The major histocompatibility complex (MHC) is a highly polymorphic genomic region that plays a central role in the immune system. Despite its functional consistency, the genomic structure of the MHC differs substantially among organisms.
Yukio Taniguchi +8 more
doaj +1 more source
The MHC and the Recognition of Self and Altered Self in Experimental and Rheumatoid Arthritis [PDF]
, 2014 The Major histocompatibility complex (MHC) is a highly polymorphic and genedense region on chromosome 6 in humans and 20 in the rat. Genes in the MHC are the major risk factor for the development of autoimmunity.
Haag, Sabrina
core +1 more source
MHC class I and II genes in Serpentes [PDF]
, 2020 AbstractGenes of the major class I and II histocompatibility complex have been extensively studied in mammals. Studies of these antigens in reptiles are very scarce. Here we describe the characteristics of these genes in the suborder Serpentes. We identified the presence of a much larger number of molecules of class I and beta chains of class II than ...
D.N. Olivieri +2 more
openaire +1 more source
Location, location, location: the evolutionary history of CD1 genes and the NKR-P1/ligand systems [PDF]
, 2016 CD1 genes encode cell surface molecules that present lipid antigens to various kinds of T lymphocytes of the immune system. The structures of CD1 genes and molecules are like the major histocompatibility complex (MHC) class I system, the loading of ...
Kaufman, Jim, Rogers, Sally L
core +2 more sources
F1000Research, 2018 This correspondence concerns a publication by Malmstrøm et al. in Nature Genetics in October 2016. Malmstrøm et al. made an important contribution to fish phylogeny research by using low-coverage genome sequencing for comparison of 66 teleost (modern ...
Johannes M. Dijkstra, Unni Grimholt
doaj +1 more source
Cryptic MHC Polymorphism Revealed but Not Explained by Selection on the Class IIB Peptide-Binding Region [PDF]
, 2012 The immune genes of the major histocompatibility complex (MHC) are characterized by extraordinarily high levels of nucleotide and haplotype diversity. This variation is maintained by pathogen-mediated balancing selection that is operating on the peptide ...
Barcaccia +32 more
core +1 more source
Block-based Bayesian epistasis association mapping with application to WTCCC type 1 diabetes data [PDF]
, 2014 Interactions among multiple genes across the genome may contribute to the risks of many complex human diseases. Whole-genome single nucleotide polymorphisms (SNPs) data collected for many thousands of SNP markers from thousands of individuals under the ...
Liu, Jun, Zhang, Jing, Zhang, Yu
core +1 more source