Results 11 to 20 of about 97,657 (267)

Lack of association between alopecia areata and HLA class I and II in a southeastern Brazilian population [PDF]

Anais Brasileiros de Dermatologia, 2016
: Background: Alopecia areata (AA) is a common disorder of unknown etiology that affects approximately 0.7% to 3.8% of patients among the general population. Currently, genetic and autoimmune factors are emphasized as etiopathogenic.
Ângela Marques Barbosa, Luiz Euribel Prestes-Carneiro, Aldri Roberta Sodoschi Sobral, Marcelo Jun Sakiyama, Bruna Cerávolo Lemos, Marilda Aparecida Milanez Morgado de Abreu, Luciana Leite Crivelin Martos, Ricardo Alberto Moliterno   +7 more
doaj   +1 more source

Atlantic cod (Gadus morhua) MHC I localizes to endolysosomal compartments independently of cytosolic sorting signals

Frontiers in Cell and Developmental Biology, 2023
Major histocompatibility complex (MHC) class I and II are crucial for the adaptive immune system because they are involved in peptide presentation to T cells.
Synne Arstad Bjørnestad, Monica Hongrø Solbakken, Kjetill S. Jakobsen, Sissel Jentoft, Oddmund Bakke, Cinzia Progida   +5 more
doaj   +1 more source

Allelic diversity and patterns of selection at the major histocompatibility complex class I and II loci in a threatened shorebird, the Snowy Plover (Charadrius nivosus)

BMC Evolutionary Biology, 2020
Background Understanding the structure and variability of adaptive loci such as the major histocompatibility complex (MHC) genes is a primary research goal for evolutionary and conservation genetics.
Medardo Cruz-López, Guillermo Fernández, Helen Hipperson, Eduardo Palacios, John Cavitt, Daniel Galindo-Espinosa, Salvador Gómez del Angel, Raya Pruner, Oscar Gonzalez, Terry Burke, Clemens Küpper   +10 more
doaj   +1 more source

Cohesin Regulates MHC Class II Genes through Interactions with MHC Class II Insulators [PDF]

The Journal of Immunology, 2011
Abstract Cohesin is a multiprotein, ringed complex that is most well-known for its role in stabilizing the association of sister chromatids between S phase and M. More recently, cohesin was found to be associated with transcriptional insulators, elements that are associated with the organization of chromatin into regulatory domains.
Parimal, Majumder, Jeremy M, Boss
openaire   +2 more sources

Genetic diversity, evolution and selection in the major histocompatibility complex DRB and DQB loci in the family Equidae

BMC Genomics, 2020
Background The mammalian Major Histocompatibility Complex (MHC) is a genetic region containing highly polymorphic genes with immunological functions. MHC class I and class II genes encode antigen-presenting molecules expressed on the cell surface.
Marie Klumplerova, Petra Splichalova, Jan Oppelt, Jan Futas, Aneta Kohutova, Petra Musilova, Svatava Kubickova, Roman Vodicka, Ludovic Orlando, Petr Horin   +9 more
doaj   +1 more source

Modulation of Gene Expression by the MHC Class II Transactivator [PDF]

The Journal of Immunology, 2002
Abstract The class II transactivator (CIITA) is a master regulator of MHC class II expression. CIITA also modulates the expression of MHC class I genes, suggesting that it may have a more global role in gene expression. To determine whether CIITA regulates genes other than the MHC class II and I family, DNA microarray analysis was ...
Uma M, Nagarajan, Alyssa, Bushey, Jeremy M, Boss   +2 more
openaire   +2 more sources

Multiple expressed MHC class II loci in salmonids; details of one non-classical region in Atlantic salmon (Salmo salar)

BMC Genomics, 2008
Background In teleosts, the Major Histocompatibility Complex (MHC) class I and class II molecules reside on different linkage groups as opposed to tetrapods and shark, where the class I and class II genes reside in one genomic region. Several teleost MHC
Bakke Hege G, Lukacs Morten F, Harstad Håvard, Grimholt Unni   +3 more
doaj   +1 more source

Major histocompatibility complex genomic investigation of endangered Chinese alligator provides insights into the evolution of tetrapod major histocompatibility complex and survival of critically bottlenecked species

Frontiers in Ecology and Evolution, 2022
BackgroundThe major histocompatibility complex (MHC) gene family, a vital immune gene family in vertebrates, helps animals defend against pathogens. The polymorphism of MHC genes is important for a species and is considered to be caused by the numerous ...
Ke He, Ke He, Ying Zhu, Ying Zhu, Shang-Chen Yang, Qing Ye, Qing Ye, Sheng-Guo Fang, Qiu-Hong Wan   +8 more
doaj   +1 more source

Allelic diversity and selection at the MHC class I and class II in a bottlenecked bird of prey, the White-tailed Eagle

BMC Evolutionary Biology, 2019
Background Genes of the Major Histocompatibility Complex (MHC) are essential for adaptive immune response in vertebrates, as they encode receptors that recognize peptides derived from the processing of intracellular (MHC class I) and extracellular (MHC ...
Piotr Minias, Ewa Pikus, Dariusz Anderwald   +2 more
doaj   +1 more source

Major histocompatibility complex in Osteichthyes

Journal of Veterinary Research, 2020
Based on analysis of available genome sequences, five gene lineages of MHC class I molecules (MHC I-U, -Z, -S, -L and -P) and one gene lineage of MHC class II molecules (MHC II-D) have been identified in Osteichthyes.
Stosik Michał, Tokarz-Deptuła Beata, Deptuła Wiesław   +2 more
doaj   +1 more source