Results 21 to 30 of about 97,657 (267)
A novel HURRAH protocol reveals high numbers of monomorphic MHC class II loci and two asymmetric multi-locus haplotypes in the Père David's deer. [PDF]
PLoS ONE, 2011 The Père David's deer is a highly inbred, but recovered, species, making it interesting to consider their adaptive molecular evolution from an immunological perspective.
Qiu-Hong Wan +7 more
doaj +1 more source
Toxins, 2012 Anthrax Lethal Toxin consists of Protective Antigen (PA) and Lethal Factor (LF), and current vaccination strategies focus on eliciting antibodies to PA. In human vaccination, the response to PA can vary greatly, and the response is often directed toward ...
Judith A. James +8 more
doaj +1 more source
The Structure of Human MHC Class II Genes
Autoimmunity, 1991 The class II molecules of the human major histocompatibility complex bind intracellularly processed peptides and present them to T-helper cells. They therefore have a critical role in the initiation of the immune response. A salient feature of the class II molecules is their polymorphism.
L, Rask +4 more
openaire +2 more sources
The Major Histocompatibility Complex of Old World Camels—A Synopsis
Cells, 2019 This study brings new information on major histocompatibility complex (MHC) class III sub-region genes in Old World camels and integrates current knowledge of the MHC region into a comprehensive overview for Old World camels.
Martin Plasil +5 more
doaj +1 more source
Frontiers in Immunology, 2021 Structures of peptide-loaded major histocompatibility complex class I (pMHC-I) and class II (pMHC-II) complexes are similar. However, whereas pMHC-II complexes include similar-sized IIα and IIβ chains, pMHC-I complexes include a heavy chain (HC) and a ...
Yanan Wu +4 more
doaj +1 more source
Selection and trans-species polymorphism of major histocompatibility complex class II genes in the order Crocodylia. [PDF]
PLoS ONE, 2014 Major Histocompatibility Complex (MHC) class II genes encode for molecules that aid in the presentation of antigens to helper T cells. MHC characterisation within and between major vertebrate taxa has shed light on the evolutionary mechanisms shaping the
Weerachai Jaratlerdsiri +4 more
doaj +1 more source
Biology, 2016 Major histocompatibility complex (MHC) molecules are key players in initiating immune responses towards invading pathogens. Both MHC class I and class II genes are present in teleosts, and, using phylogenetic clustering, sequences from both classes have ...
Unni Grimholt
doaj +1 more source
MHC class I and II genes in Serpentes [PDF]
, 2020 Abstract Genes of the major class I and II histocompatibility complex have been extensively studied in mammals. Studies of these antigens in reptiles are very scarce. Here we describe the characteristics of these genes in the suborder Serpentes.
D.N. Olivieri +2 more
openaire +1 more source
Giant panda genomic data provide insight into the birth-and-death process of mammalian major histocompatibility complex class II genes. [PDF]
PLoS ONE, 2009 To gain an understanding of the genomic structure and evolutionary history of the giant panda major histocompatibility complex (MHC) genes, we determined a 636,503-bp nucleotide sequence spanning the MHC class II region.
Qiu-Hong Wan +4 more
doaj +1 more source
Comparative genome analyses reveal distinct structure in the saltwater crocodile MHC.
PLoS ONE, 2014 The major histocompatibility complex (MHC) is a dynamic genome region with an essential role in the adaptive immunity of vertebrates, especially antigen presentation.
Weerachai Jaratlerdsiri +14 more
doaj +1 more source