PML promotes MHC class II gene expression by stabilizing the class II transactivator [PDF]
Journal of Cell Biology, 2012 Promyelocytic leukemia (PML) nuclear bodies selectively associate with transcriptionally active genomic regions, including the gene-rich major histocompatibility (MHC) locus. In this paper, we have explored potential links between PML and interferon (IFN)-γ–induced MHC class II expression.
Ulbricht, Tobias +9 more
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Selection and trans-species polymorphism of major histocompatibility complex class II genes in the order Crocodylia. [PDF]
PLoS ONE, 2014 Major Histocompatibility Complex (MHC) class II genes encode for molecules that aid in the presentation of antigens to helper T cells. MHC characterisation within and between major vertebrate taxa has shed light on the evolutionary mechanisms shaping the
Weerachai Jaratlerdsiri +4 more
doaj +1 more source
A pentapeptide as minimal antigenic determinant for MHC class I-restricted T lymphocytes [PDF]
, 1989 Peptides that are antigenic for T lymphocytes are ligands for two receptors, the class I or II glycoproteins that are encoded by genes in the major histocompatibility complex, and the idiotypic / chain T-cell antigen receptor1–9. That a peptide must bind
A Sette +30 more
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Giant panda genomic data provide insight into the birth-and-death process of mammalian major histocompatibility complex class II genes. [PDF]
PLoS ONE, 2009 To gain an understanding of the genomic structure and evolutionary history of the giant panda major histocompatibility complex (MHC) genes, we determined a 636,503-bp nucleotide sequence spanning the MHC class II region.
Qiu-Hong Wan +4 more
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Contrasting patterns of selection between MHC I and II across populations of Humboldt and Magellanic penguins [PDF]
, 2016 Indexación: Web of ScienceThe evolutionary and adaptive potential of populations or species facing an emerging infectious disease depends on their genetic diversity in genes, such as the major histocompatibility complex (MHC). In birds, MHC class I deals
Dantas, GPM +7 more
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Medicine, 2001 IntroductionPrimary human immunodeficiencies constitute a heterogenous group of inborn errors of the immune system due to a variety of genetic abnormalities. The study of patients with primary immunodeficiency diseases has expanded our understanding of immunity.
J, Villard +4 more
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Comparative genome analyses reveal distinct structure in the saltwater crocodile MHC.
PLoS ONE, 2014 The major histocompatibility complex (MHC) is a dynamic genome region with an essential role in the adaptive immunity of vertebrates, especially antigen presentation.
Weerachai Jaratlerdsiri +14 more
doaj +1 more source
The Marine Mammal Class II Major Histocompatibility Complex Organization
Frontiers in Immunology, 2019 Sirenians share with cetaceans and pinnipeds several convergent traits selected for the aquatic lifestyle. Living in water poses new challenges not only for locomotion and feeding but also for combating new pathogens, which may render the immune system ...
André Luiz Alves de Sá +7 more
doaj +1 more source
Immunogenetic variation and differential pathogen exposure in free-ranging cheetahs across Namibian farmlands. [PDF]
PLoS ONE, 2012 Genes under selection provide ecologically important information useful for conservation issues. Major histocompatibility complex (MHC) class I and II genes are essential for the immune defence against pathogens from intracellular (e.g.
Aines Castro-Prieto +5 more
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Tolerance to MHC class II disparate allografts through genetic modification of bone marrow [PDF]
, 2014 Induction of molecular chimerism through genetic modification of bone marrow is a powerful tool for the induction of tolerance. Here we demonstrate for the first time that expression of an allogeneic MHC class II gene in autologous bone marrow cells ...
Bagley, Jessamyn +4 more
core +1 more source