Results 61 to 70 of about 96,655 (307)
Origin and evolution of TRIM proteins: new insights from the complete TRIM repertoire of zebrafish and pufferfish [PDF]
, 2011 Tripartite motif proteins (TRIM) constitute a large family of proteins containing a RING-Bbox-Coiled Coil motif followed by different C-terminal domains. Involved in ubiquitination, TRIM proteins participate in many cellular processes including antiviral
Pierre Pontarotti +39 more
core +2 more sources
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective In multiple sclerosis, the optimal time for deploying a therapeutic intervention is before the central nervous system is damaged; given the success of trials treating the earliest stage of MS, the radiologically isolated syndrome, developing primary prevention strategies is an important next challenge.
Amy W. Laitinen +7 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao +6 more
wiley +1 more source
The porcine Major Histocompatibility Complex and related paralogous regions: a review
Genetics Selection Evolution, 2000 The physical alignment of the entire region of the pig major histocompatibility complex (MHC) has been almost completed. In swine, the MHC is called the SLA (swine leukocyte antigen) and most of its class I region has been sequenced.
Vaiman Marcel +3 more
doaj +1 more source
From Adult to Adolescent: Alignment in Clinical Trials and Outcomes in Axial Spondyloarthritis
Arthritis Care &Research, Accepted Article.Spondyloarthritis (SpA) is a group of chronic inflammatory diseases encompassing axial and peripheral forms, with up to 20% of patients developing symptoms before age 16. Despite this substantial pediatric burden, treatment options for juvenile‐onset SpA (JSpA), particularly those with axial disease (axJSpA), remain limited.
Pamela F. Weiss +9 more
wiley +1 more source
The isolation and characterisation of MHC-presented peptides from CML-derived cell-lines, with a focus on post-translational modification [PDF]
, 2011 Phosphorylation is a key regulator of protein function and activity, and aberrant kinase activity is implicated in a wide range of malignancies, of which the bcr:abl fusion kinase found in chronic myeloid leukaemia is a classic example.
Kapoor, KN
core
Bayesian phylogenetic tree of MHC class II A genes. [PDF]
, 2014 The fish MHC class II A sequence (Onmy-DAA; AFP94173) is used as an outgroup. A bracket on the right shows the DAA gene lineage of the MHC genes from Crocodylia identified in the current study and previous publications as described in Materials and ...
Sylvain Marthey (80518) +14 more
core +1 more source
Scientific Reports, 2017 The multi-subunit CCR4 (carbon catabolite repressor 4)-NOT (Negative on TATA) complex serves as a central coordinator of all different steps of eukaryotic gene expression.
Alfonso Rodríguez-Gil +9 more
doaj +1 more source
Advanced Functional Materials, EarlyView.This article details the development of an artery‐on‐chip platform for in vitro arterial disease modeling and therapeutic discovery. It describes the fabrication of a fibrin biomaterial scaffold seeded with iPSC‐derived smooth muscle and endothelial cells, mimicking native artery properties. Two genetic disease models showcase the platform's ability to
Danielle Yarbrough +10 more
wiley +1 more source
Evolution of MHC diversity in cetacean species environment: implications for the role of a pathogen [PDF]
, 2004 Previous studies have indicated that the evolution of diversity in the immune system genes responsible for antigen presentation in terrestrial mammals is driven by selection.
Vassilakos, Demetrios
core