Results 211 to 220 of about 9,502,784 (300)

Immune-mediated tumor regression and subsequent escape driven by antigen loss and major histocompatibility complex (MHC) class I downregulation following GPC3 DNA vaccination in hepatocellular carcinoma. [PDF]

Hepatobiliary Surg Nutr
Li H, Wang X, Yan Z, Weng S, Kang W, Xi J, Yang Z.   +6 more
europepmc   +1 more source

HLA‐A*11:01 Identifies Patients at Risk for Persistent Viraemia and Advanced Fibrosis in HDV Infection

Alimentary Pharmacology &Therapeutics, EarlyView.
The HLA‐A*11:01 allele is associated with persistent viraemia and advanced liver fibrosis in HDV infection. HLA‐A*11:01 carriers exhibit a reduced T‐cell repertoire, suggesting a narrower T‐cell response to the infection. ABSTRACT Background Hepatitis delta virus (HDV) infection causes the most severe form of viral hepatitis, with highly heterogeneous ...
Maria Francesca Cortese, Adriana Palom, Ariadna Rando Segura, Francesc Rudilla, Emma Enrich Rande, Arnau Puig Lopez, David Tabernero Caellas, Judit Vico Romero, Juan Carlos Ruiz‐Cobo, Mar Riveiro‐Barciela, Maria José Herrero, Maria Buti   +11 more
wiley   +1 more source

Next-Generation Short-Read Sequencing Reveals Impacts on Major Histocompatibility Complex Diversity Resulting From Differences in Captive Rhesus Macaque (Macaca Mulatta) Colony Expansion Strategies. [PDF]

Am J Primatol
Kanthaswamy S, Wiseman RW, Stauss MR, Ertl MC, Patel DK, Smith DG, Martínez MI, Maldonado E, Sariol CA.   +8 more
europepmc   +1 more source

From haemostasis to immunity: The expanding frontiers of platelet biology

British Journal of Haematology, EarlyView.
Platelets are versatile cells whose functions extend far beyond haemostasis and thrombosis, actively regulating innate and adaptive immunity, angiogenesis, lymphangiogenesis, liver regeneration, atherosclerosis and tumour metastasis. This demonstrates their central role in various physiological processes and multiple life‐threatening diseases ...
Xun Grace Wu, Nicole Tomei, Heyu Ni
wiley   +1 more source

On the impact of local protein structure features on prediction of major histocompatibility complex class I and II antigen presentation. [PDF]

Brief Bioinform
Wan YR, Nielsen M.
europepmc   +1 more source

PIPLOM: prediction of exogenous peptide loading on major histocompatibility complex class I molecules. [PDF]

Bioinform Adv
Schmidt F, Wu K, Gerber L, Chioh Wen Jing F, Carbajo D, Wong Choon Lim G, Wirawan M, Eng C, Fink K, MacLeod DT, Fehlings M, Wilm A.   +11 more
europepmc   +1 more source

Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges

British Journal of Pharmacology, EarlyView.
This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu, Kaibin Dai, Zhensheng Lin, Mingfang Ye, Minfeng Chen, Xiaobo Li, Dongmei Zhang   +6 more
wiley   +1 more source

Targeting KRAS for cancer therapy

British Journal of Pharmacology, EarlyView.
In recent years, therapeutics targeted against KRAS proto‐oncogene GTPase (KRAS)‐mutant cancers have seen significant progress. Herein we outline the biology and epidemiology of KRAS alterations at the lineage and allele levels, reviewing the clinical evidence for KRASG12C inhibition from the discovery of the recessive switch pocket to sotorasib ...
Jianlong Jia, Ruonan Liu, Tonia A. Adamide, Isis E. Fernandez, Georgios T. Stathopoulos   +4 more
wiley   +1 more source

NGSMHC: a simple bioinformatics tool for comprehensively typing major histocompatibility complex genes in non-human species using next-generation sequencing data. [PDF]

Anim Biosci
Kang M, Ahn B, Shin JY, Lee J, Cho ES, Park C.   +5 more
europepmc   +1 more source

Immune checkpoint inhibitor‐induced arrhythmias: Mechanistic insights from clinical and preclinical studies

British Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitors (ICIs) have transformed cancer therapy, but their efficacy continues to be limited by immune‐related adverse events. Among these, ICI‐induced cardiac arrhythmias are increasingly recognised as a major adverse reaction, encompassing a broad spectrum of clinical phenotypes, including conduction blocks, atrial fibrillation and
Anand R. Ramalingam, Zoltán Márton Köhler, Péter Ferdinandy, Zoltán V. Varga   +3 more
wiley   +1 more source