Results 201 to 210 of about 293 (242)

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

open access: yesAging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

open access: yesAging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang   +3 more
wiley   +1 more source

Construction of simple majorizing sequences for iterative methods

Applied Mathematics Letters, 2019
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
J A Ezquerro, M A Hernández-Verón
exaly   +2 more sources

Estimates of Majorizing Sequences in the Newton–Kantorovich Method

Numerical Functional Analysis and Optimization, 2006
Let f:B(x 0,R) ⊆ X → Y be an operator, with X and Y Banach spaces, and f′ be Holder continuous with exponent θ. The convergence of the sequence of Newton–Kantorovich approximations is a classical tool to solve the equation f(x) = 0. The convergence of x n is often reduced to the study of the majorizing sequence r n defined by with a, b, k parameters ...
Filomena Cianciaruso   +1 more
exaly   +3 more sources

Majorizing Sequences for Nonlinear Fredholm–Hammerstein Integral Equations

open access: yesStudies in Applied Mathematics, 2017
AbstractWe use the method of majorizing sequences to study the applicability of Newton's method to solve nonlinear Fredholm–Hammerstein integral equations. For this, we use center convergence conditions on points different from the starting point of Newton's method, which is the point usually used by other authors until now when center conditions are ...
José A. Ezquerro   +1 more
openaire   +3 more sources

Majorizing sequences for Newton’s method from initial value problems [PDF]

open access: yesJournal of Computational and Applied Mathematics, 2012
The most restrictive condition used by Kantorovich for proving the semilocal convergence of Newton's method in Banach spaces is relaxed in this paper, providing we can guarantee the semilocal convergence in situations that Kantorovich cannot.
J A Ezquerro   +2 more
exaly   +3 more sources

Estimates of majorizing sequences in the Newton–Kantorovich method: A further improvement

open access: yesJournal of Mathematical Analysis and Applications, 2006
Let f:B(x0,R)⊆X→Y be an operator, with X and Y Banach spaces, and f′ be Hölder continuous with exponent θ. The convergence of the sequence of Newton–Kantorovich approximationsxn=xn−1−f′(xn−1)−1f(xn−1),n∈N, is a classical tool to solve the equation f(x)=0.
Filomena Cianciaruso   +1 more
exaly   +2 more sources

Power Majorization and Majorization of Sequences

Results in Mathematics, 1988
Let \(x,y\in R^ n_+\) be such that \(x_ 1\geq...\geq x_ n\), \(y_ 1\geq...\geq y_ n\) and \(\sum x_ i=\sum y_ i.\) We say that x is power majorized by y if \(\sum x^ p_ i\leq \sum y^ p_ i\) for all real \(p\not\in [0,1]\) and \(\sum x^ p_ i\geq \sum y^ p_ i\) for \(p\in [0,1]\). Let \(\phi\) : [0,\(\infty)\to R\) be a continuous function.
openaire   +1 more source

Sequence microheterogeneity of parvalbumin, the major fish allergen

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2013
The microheterogeneity of amino acid sequence observed in various allergens may affect immune response, but incidence of sequence microheterogeneity in allergens and its relation to their allergenicity are unclear. The occurrence of sequence microheterogeneity in major fish allergen, parvalbumin (PA), has been explored using bioinformatics approaches ...
Lapteva, Yulia S.   +2 more
openaire   +3 more sources

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